[1-(4-Chlorophenyl)cyclopropyl](piperazin-1-yl)methanone

The title compound, [1-(4-chlorophenyl)cyclopropyl](piperazin-1-yl)methanone, was synthesized and characterized by elemental analysis, IR, 1H NMR, 13C NMR and mass spectral data

2-[(4-Bromophenylimino)methyl]-5-pentadecylphenol

2-[(4-Bromophenylimino)methyl]-5-pentadecylphenol has been synthesized by reaction of 2-hydroxy-4-pentadecylbenzaldehyde with 4-bromoaniline in 1,4-dioxane and its IR, 1H-NMR, 13C-NMR and MS spectroscopic data are presented

1-[4-Bromo-2-(trifluoromethoxy)phenyl]-3-methyl-1H-1,2,4-triazole

In the title compound, C10H7BrF3N3O, the dihedral angle between the benzene and triazole rings is 23.17 (12)° and the C atom of the –CF3 group deviates from its attached ring plane by 1.147 (3) Å. In the crystal, molecules are linked by C—H...N interactions, generating C(7) chains running along [010]

Synthesis of novel angularly fused pentacyclic heterocycles of pharmacological interest

1446-14512-Substituted-4-oxo-naphtho[2,1-b]furo[3,2-d]pyrimidines 1a-c on refluxing with phosphorous oxychloride result in the formation of 2-substituted-4-chloronaphtho[2,1-b]furo[3,2-d]pyrimidines 2a-c, which on nucleophilic substitution reaction with hydrazine hydrate in ethanol give the required 2-substituted-4-hydrazinonaphtho[2,1-b]furo[3,2-d]pyrimidines 3a-c. The compounds 3a-c are converted into novel angularly fused pentacyclic heterocycles viz. tetrazolo[1,5-c]­pyrimido[5,4-b]naphtho[2,1-b]furan derivatives 4a-c and triazolo[4,3-c]pyrimido[5,4-b]naphtho[2,1-b]furan derivatives 5a-i by reacting with appropriate reagents. Condensation of 3a-c with typical aldehydes afford a series of 4-arylidine­hydrazinonaphtho[2,1-b]furo[3,2-d]pyrimidines 6a-o. All the newly synthesized compounds have been characterized by elemental analysis and spectroscopic data and have been evaluated for antimicrobial, anthelmintic, anticonvulsant and antipyretic activities

Synthesis, antimicrobial and antiinflammatory activities of 1,3,4-oxadiazoles linked to naphtho[2,1-<i style="">b</i>]furan

2506-2511Condensation of naphtho[2,1-b]furan-2-carboxyhydrazide 1 with different aromatic aldehydes affords the corresponding N1-[(1E)-arylmethylene]-naphtho[2,1-b]furan-2-carboxyhydrazides 2a-h. These compounds undergo cyclization with acetic anhydride and mercuric oxide to yield 3-acetyl-5-naphtho[2,1-b]furan-2-yl-2-aryl-2,3-dihydro-1,3,4-oxadiazoles 3a-h and 2-naphtho[2,1-b]furan-2-yl-5-aryl-1,3,4-oxadiazoles 4a-h respectively. The compound 1 on refluxing with carbon disulphide and ethanolic potassium hydroxide followed by acidification with hydrochloric acid furnishes 5-naphtho[2,1-b]furan-2-yl-1,3,4-oxadiazole-2(3H)-thione 5. It is converted into Mannich bases 3-(anilinomethyl)-5-naphtho[2,1-b]furan-2-yl-1,3,4-oxadiazole-2(3H)-thiones 6a-h on treatment with formaldehyde and appropriate aromatic amines. All the newly synthesized compounds are characterized by elemental analysis and spectral studies. The selected compounds have been screened for their antimicrobial and anti-inflammatory activities.</sub

ANTIMICROBIAL EVALUATION OF NOVEL SUBSTITUTED PYRIMIDINOPYRAZOLES AND PYRIMIDINOTRIAZOLES

Some novel substituted pyramidinopyrazoles and pyrimidinotriazoles have been synthesized by using 6-anisyl-5-cyan-2-hydrazine-3-N-methyl-3, 4-dihydropyrimidine-4-one as the starting material. Structures of these compounds have been established by IR, 1H NMR, Mass and elemental analysis data and have been evaluated for their antimicrobial activity. Significant antimi.crobial activity was observed for some members of these series

Greener synthesis of indolizine analogues using water as a base and solvent: Study for larvicidal activity against Anopheles arabiensis

Greener synthesis of a series of novel indolizine analogues have been achieved by the cyclization of aromatic cycloimmonium ylides with electron-deficient alkynes in the presence of water as the base and solvent at 80 °C. Yield of the title compounds was good and reactions performed were eco-friendly. The structures of these newly synthesized compounds have been confirmed by spectroscopic techniques such as FTIR, NMR, LC-MS, and elemental analysis. Characterized title compounds were evaluated for larvicidal activity against Anopheles arabiensis by standard WHO larvicidal assay using Temefos as standard at 4 μg/mL. Title compounds 2e, 2f, and 2g emerged as promising larvicidal agents.Fil: Sandeep, Chandrashekharappa. Institute For Stem Cell Biology And Regenerative Medic; IndiaFil: Venugopala, Katharigatta N.. Durban University Of Technology; SudáfricaFil: Gleiser, Raquel M.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinar de Biología Vegetal (P). Grupo Vinculado Centro de Relevamiento y Evaluación de Recursos Agrícolas y Naturales; ArgentinaFil: Chetram, Abeen. Durban University Of Technology; SudáfricaFil: Padmashali, Basavaraj. Rani Channamma University; IndiaFil: Kulkarni, Rashmi S.. Jain University; IndiaFil: Venugopala, Rashmi. University Of Kwazulu-natal; SudáfricaFil: Odhav, Bharti. Durban University Of Technology; Sudáfric