An efficient transformation of ethers to N,Nâ²-disubstituted ureas in a Ritter type reaction

A simple, mild, and an alternative protocol for the preparation of N,Nâ²-disubstituted ureas from readily available ethers and cyanamides as starting materials is described. The protocol explores the reactivity of ether in a Ritter type reaction with cyanamide in the presence of BF 3·Et2O and resulting in the formation of N,Nâ²-disubstituted urea. Divinyl ether as well as MTBE (methyl tert-butyl ether) can be employed as ether components to afford allyl and tert-butyl ureas respectively. © 2012 Elsevier Ltd. All rights reserved

Facile Synthesis of N α -Protected Amino/Peptide Hydroxamic Acids Mediated by Comu

One-pot preparation of N α -protected amino/peptide hydroxamic acids from corresponding carboxylic acids is described using uronium-type coupling reagent COMU. The present protocol is simple and mild conditions are used. Thus the resulting hydroxamic acids are obtained in good yields without racemization

Multiple intracerebral lesions in a young male

Background: As the incidence of HIV infection has increased its neurological complications are being encountered in our clinical practice. Toxoplasmosis is a common cerebral opportunistic infection seen in HIV-infected patients, even though the incidence has declined with the use of antiretroviral therapy. Establishing a definitive diagnosis of cerebral toxoplasmosis is difficult in resource limited settings.Clinical case: A 20 year old gentleman was referred to our institute as a case of stroke. Magnetic  resonance imaging (MRI) of his brain showed multiple ill-defined and nodular enhancing lesions in bilateral supratentorial and infratentorial neuroparenchyma. Test for HIV-1 was reactive. Toxoplasma serology revealed raised IgG antibody levels. Based on the MRI features and positive toxoplasma serology a diagnosis of cerebral  toxoplasmosis was made. He was treated with trimethoprim/ sulfamethoxazole and pyrimethamine/ Sulfadoxine for 3 weeks. After 2 weeks of treatment, repeat MRI of brain was done which showed significant resolution of the lesions.Conclusion: We are presenting this case to highlight the fact that cerebral toxoplasmosis should be  considered in the differential diagnosis of multiple neuroparenchymal lesions in young individuals who present with neurological deficits.Keywords: Cerebral toxoplasmosis; HIV/AIDS; Tuberculoma; Neurocysticercosi

A simple and greener approach for the synthesis of PVC supported Pd (0): Application to Heck and Sonogashira reactions in water

Preparation of PVC-supported Pd nanoparticles through the reduction of PdCl2 by a non-toxic and eco-friendly route, employing sodium formate and NaOH in ethanol-water system has been described. The prepared PVC supported Pd nanoparticles were employed as catalyst in the cross coupling reactions, that is, Heck and Sonogashira reactions in water medium to afford the respective products in good to excellent yields. © 2014 Elsevier Ltd. All rights reserved

Facile Synthesis of N (alpha) -Protected Amino/Peptide Hydroxamic Acids Mediated by COMU

One-pot preparation of N (alpha) -protected amino/peptide hydroxamic acids from corresponding carboxylic acids is described using uronium-type coupling reagent COMU. The present protocol is simple and mild conditions are used. Thus the resulting hydroxamic acids are obtained in good yields without racemization

ChemInform Abstract: T3P® (Propylphosphonic Anhydride) Mediated Conversion of Carboxylic Acids into Acid Azides and One‐Pot Synthesis of Ureidopeptides.

The method is high-yielding and ecofriendly

A facile route for the synthesis of novel S-linked 1,3,5-triazine tethered peptidomimetics

An efficient one-pot synthesis of Nα-protected S-linked 1,3,5-triazine tethered peptidomimetics is described. The protocol involves a three-component condensation reaction employing Nα-protected amino alkyl isothiouronium salt, formaldehyde and amino acid ester or aryl amine as reactants. Various aryl amines with substitutions and amino acids with simple as well as bifunctional side chains were employed to obtain triazine tethered peptidomimetics in good yield. © 2014 Published by Elsevier Ltd