Nanoindentation measurement on interstitial and osteon of bone with osteogenesis imperfecta-type III

"Osteogenesis imperfecta (OI) is one of the genetic disorder which was characterized by bone fragility. Previous studies reported that there are several mechanical properties has been used to investigate the strength of OI bone. However, little data is yet available to describe bone material properties in individuals with this disorder for type III alone. Therefore, the aim of this study is to investigate the mechanical properties in individual with OI bone type III at interstitial and osteon. Bone tissue reduced modulus and hardness were measured by nanoindentation in three specimens with total 40 indents. These properties were compared between osteogenesis imperfecta types III for interstitial and osteonal microstructural regions. Individual with osteogenesis imperfecta type III had higher hardness and reduced modulus at interstitial rather than osteonal bone regions. Overall, the mean and standard deviation of hardness is 0.6 ± 0.11 GPa, while 0.44± 0.06 GPa for osteon. The current study presents the dataset describing the bone material properties in individual with Osteogenesis Imperfecta Type III. Results indicate that intrinsic bone tissues properties were affected by phenotype. Knowledge on the mechanical properties of severity osteogenesis imperfecta may help to assist the model and prevent the fracture risk for those having this disorder.

Studying Female Islamic Authority: From Top-Down to Bottom-Up Modes of Certification

This article introduces a special issue on female Islamic authority in contemporary Asia. It provides an overview of the literature on religious authority in Islam and briefly lays out which modes of female religious authority have been more accepted than others in the schools of jurisprudence. Based on the articles included in this issue, the introduction makes two chief observations. First, in contrast to the overwhelming consensus among experts of Islamic law that women may serve as muftūn (plural of muftī), in most Muslim-majority societies today women are either seldom found in this role, or where there are muftīyāt (female muftūn), their role is confined to women’s issues. Second, while a growing body of academic studies has drawn attention to the recent phenomenon of state-instituted or -supported programs that train women in Islamic authority, little attention has been paid to the question of how communities react to such programs. The special issue is a call to study female religious authority from the bottom up, in order to better understand why believers, whether men or women, ascribe religious authority to women in some contexts and situations, but overwhelmingly still prefer male religious authority over female, despite the permissiveness for female juristic expertise in Islamic law.</p