The role of idiotypic interactions in the adaptive immune system: a belief-propagation approach

In this work we use belief-propagation techniques to study the equilibrium behaviour of a minimal model for the immune system comprising interacting T and B clones. We investigate the effect of the so-called idiotypic interactions among complementary B clones on the system's activation. Our result shows that B-B interactions increase the system's resilience to noise, making clonal activation more stable, while increasing the cross-talk between different clones. We derive analytically the noise level at which a B clone gets activated, in the absence of cross-talk, and find that this increases with the strength of idiotypic interactions and with the number of T cells signalling the B clone. We also derive, analytically and numerically, via population dynamics, the critical line where clonal cross-talk arises. Our approach allows us to derive the B clone size distribution, which can be experimentally measured and gives important information about the adaptive immune system response to antigens and vaccination.Comment: 37 pages, 18 figure

SHARVOT: secret SHARe-based VOTing on the blockchain

Recently, there has been a growing interest in using online technologies to design protocols for secure electronic voting. The main challenges include vote privacy and anonymity, ballot irrevocability and transparency throughout the vote counting process. The introduction of the blockchain as a basis for cryptocurrency protocols, provides for the exploitation of the immutability and transparency properties of these distributed ledgers. In this paper, we discuss possible uses of the blockchain technology to implement a secure and fair voting system. In particular, we introduce a secret share-based voting system on the blockchain, the so-called SHARVOT protocol. Our solution uses Shamir's Secret Sharing to enable on-chain, i.e. within the transactions script, votes submission and winning candidate determination. The protocol is also using a shuffling technique, Circle Shuffle, to de-link voters from their submissions.Comment: WETSEB'18:IEEE/ACM 1st International Workshop on Emerging Trends in Software Engineering for Blockchain. 5 pages, 2 figure

Item selection by Latent Class-based methods

The evaluation of nursing homes is usually based on the administration of questionnaires made of a large number of polytomous items. In such a context, the Latent Class (LC) model represents a useful tool for clustering subjects in homogenous groups corresponding to different degrees of impairment of the health conditions. It is known that the performance of model-based clustering and the accuracy of the choice of the number of latent classes may be affected by the presence of irrelevant or noise variables. In this paper, we show the application of an item selection algorithm to real data collected within a project, named ULISSE, on the quality-of-life of elderly patients hosted in italian nursing homes. This algorithm, which is closely related to that proposed by Dean and Raftery in 2010, is aimed at finding the subset of items which provides the best clustering according to the Bayesian Information Criterion. At the same time, it allows us to select the optimal number of latent classes. Given the complexity of the ULISSE study, we perform a validation of the results by means of a sensitivity analysis to different specifications of the initial subset of items and of a resampling procedure

A bivariate finite mixture growth model with selection

AbstractA model is proposed to analyze longitudinal data where two response variables are available, one of which is a binary indicator of selection and the other is continuous and observed only if the first is equal to 1. The model also accounts for individual covariates and may be considered as a bivariate finite mixture growth model as it is based on three submodels: (i) a probit model for the selection variable; (ii) a linear model for the continuous variable; and (iii) a multinomial logit model for the class membership. To suitably address endogeneity, the first two components rely on correlated errors as in a standard selection model. The proposed approach is applied to the analysis of the dynamics of household portfolio choices based on an unbalanced panel dataset of Italian households over the 1998–2014 period. For this dataset, we identify three latent classes of households with specific investment behaviors and we assess the effect of individual characteristics on households' portfolio choices. Our empirical findings also confirm the need to jointly model risky asset market participation and the conditional portfolio share to properly analyze investment behaviors over the life-cycle