13 research outputs found
Cannabidiol prevents LPSâinduced microglial inflammation by inhibiting ROS/NFâÎșBâdependent signaling and glucose consumption
Serum cannabidiol, tetrahydrocannabinol (THC), and their native acid derivatives after transdermal application of a lowâTHC Cannabis sativa
Randomized blinded controlled clinical trial to assess the effect of oral cannabidiol administration in addition to conventional antiepileptic treatment on seizure frequency in dogs with intractable idiopathic epilepsy
Thoracolumbar myelopathies in pug dogs
Abstract Background Constrictive myelopathy (CM) involving a fibrous band around the spinal cord is a newly recognized disease in pug dogs. Objectives To identify the frequency of CM based on diagnostic imaging supplemented with necropsy; to determine whether a relationship exists between the sites of CM and other described T3âL3 myelopathies; and to determine the frequency of caudal articular process dysplasia (CAPD). Animals Thirtyâtwo clientâowned pug dogs diagnosed with a chronic, progressive T3âL3 myelopathy based on neurological examination performed by a boardâcertified neurologist. Methods This is a prospective study. All dogs underwent computed tomography (CT) and magnetic resonance imaging (MRI) reviewed by a boardâcertified radiologist. Magnetic resonance imaging abnormalities were categorized into diseases; CM only, CM plus other nonâCM condition(s), or nonâCM condition. Sites of CAPD were reported on CT. Nineteen dogs underwent necropsy. Results Magnetic resonance imaging revealed 3 dogs with CM only, 17 with CM plus at least 1 other myelopathy, 11 dogs with nonâCM myelopathies only, and 1 with no MRI abnormalities. Nineteen of 32 dogs had >1 myelopathy diagnosis on MRI whereas 15/32 had >1 site of spinal cord compression. All dogs had CAPD at >1 site in the T3âL3 vertebral column on CT. Conclusions and Clinical Importance Constrictive myelopathy affected more than half of pug dogs presenting with chronic thoracolumbar myelopathies. Most had multilevel disease, concurrent myelopathies, or both. There was no apparent relationship between anatomic locations of CAPD and most severe myelopathy or myelopathy type