Relationship between ABO Blood Groups and Lipid Profile Level in Healthy Adult Residents in Port Harcourt Metropolis, Nigeria

A multitude of risk factors are responsible for development of cardiovascular diseases (CVDs) and association of cardiovascular disease risk factors with the ABO blood antigens is increasingly being reported. Thus, this study was designed to investigate the relationship between ABO blood groups and lipoprotein profiles of apparently 150 healthy adult patients attending Braithwaite Memorial Specialist Hospital, Port Harcourt, Nigeria following due consent to participate in the study. The serum TC, HDL-C, LDL-C and VLDL-C levels were determined by standard methods. ABO blood grouping was carried out by standard tile technique. Results show that the mean of the TC and LDL-C of most of the subjects in all the blood groups appeared desirable (< 5.81 mmol/L and < 3.37 mmol/L) respectively in both males and females. HDL-C was deficient in all blood groups both in males and females while the triglycerides level in the subjects was desirable (< 2.83 mmol/L). While significant variation (p<0.05) was observed between the means of the blood groups in the females, no such variation was seen the males. Strong positive correlations were observed between the lipoproteins in blood group B, AB and O females. As a result of the fact the rate of prevalence of CVD in our population is increasing, it is recommended that diagnosis, management and treatment of CVD in Nigeria should take into consideration the blood group status of the subjects.Key Words: Lipoproteins, Blood groups, cardiovascular diseases, triglyceride

Evaluation of the levels of renal indices and blood pressure in Type 2 diabetes mellitus, hypertensive and normotensive subjects in Port Harcourt, Nigeria

This study was designed to find out the impact of diabetes mellitus on the renal integrity of diabetic patients following exposure to hypertension and diabetes. This was achieved by examining the urea and creatinine concentrations and creatinine clearance of both diabetics and non-diabetics in Port Harcourt. A total of 165 subjects comprising 32 (19.39%) male diabetics, 53 (31.12%) female diabetics, 48 (29.09%) nondiabetic males and 32 (19.39%) non-diabetic females participated in the study. Results showed that 9.09% of male and 21.91% of female diabetics were hypertensive. Mean urea concentrations obtained were 6.35 ±1.55 mmol/L and 5.56 ± 2.24 mmol/L in the diabetic males and females respectively while in the non-diabetic males and females, the results were 5.66 ± 1.23 mmol/L and 5.07 ± 1.71 mmol/L respectively which was not significantly different (p>0.05, F crit. = 1.98). The creatinine concentration in the diabetic males and females were 93.46 ± 24.97 μmol/L and 89.15 ± 28.01 μmol/L respectively while in the non-diabetic male and female subjects it was 84.64 ± 29.06 μmol/L and 81.69 ± 37.27 μmol/L respectively. These means were not significant (p>0.05, F crit. = 1.65). In both male and female diabetics, the creatinine  clearance was reduced in the subjects following 8 years and above of exposure to diabetes mellitus, which is an indication of commencement of progressive loss of renal function in the diabetic patients. Thus, measurement of creatinine clearance should be included in the routine assessment of renal function especially in type 2 diabetes mellitus patients.Keywords: Renal failure, diabetes mellitus, hyperglycaemia, hypoglycaemia, renal clearance

Relationship between ABO Blood Groups and Lipid Profile Level in Healthy Adult Residents in Port Harcourt Metropolis, Nigeria

A multitude of risk factors are responsible for development of cardiovascular diseases (CVDs) and association of cardiovascular disease risk factors with the ABO blood antigens is increasingly being reported. Thus, this study was designed to investigate the relationship between ABO blood groups and lipoprotein profiles of apparently 150 healthy adult patients attending Braithwaite Memorial Specialist Hospital, Port Harcourt, Nigeria following due consent to participate in the study. The serum TC, HDL-C, LDL-C and VLDL-C levels were determined by standard methods. ABO blood grouping was carried out by standard tile technique. Results show that the mean of the TC and LDL-C of most of the subjects in all the blood groups appeared desirable (< 5.81 mmol/L and < 3.37 mmol/L) respectively in both males and females. HDL-C was deficient in all blood groups both in males and females while the triglycerides level in the subjects was desirable (< 2.83 mmol/L). While significant variation (p<0.05) was observed between the means of the blood groups in the females, no such variation was seen the males. Strong positive correlations were observed between the lipoproteins in blood group B, AB and O females. As a result of the fact the rate of prevalence of CVD in our population is increasing, it is recommended that diagnosis, management and treatment of CVD in Nigeria should take into consideration the blood group status of the subjects.Key Words: Lipoproteins, Blood groups, cardiovascular diseases, triglyceride