Synthesis, Characterization, and Biological Studies of Organotin(IV) Derivatives with o- or p-hydroxybenzoic Acids

Organotin(IV) complexes with o- or p-hydroxybenzoic acids (o-H2BZA or p-H2BZA) of formulae [R2Sn(HL)2] (where H2L = o-H2BZA and R = Me- (1), n-Bu- (2)); [R3Sn(HL)] (where H2L = o-H2BZA and R = n-Bu- (3), Ph- (4) or H2L = p-H2BZA and R = n-Bu- (5), Ph- (6)) were synthesized by reacting a methanolic solution of di- and triorganotin(IV) compounds with an aqueous solution of the ligand (o-H2BZA or p-H2BZA) containing equimolar amounts of potassium hydroxide. The complexes were characterized by elemental analysis, FT-IR, Far-IR, TGA-DTA, FT-Raman, Mössbauer spectroscopy, 1H, 119Sn-NMR, UV/Vis spectroscopy, and Mass spectroscopy. The X-ray crystal structures of complexes 1 and 2 have also been determined. Finally, the influence of these complexes 1–6 upon the catalytic peroxidation of linoleic acid to hydroperoxylinoleic acid by the enzyme lipoxygenase (LOX) was kinetically studied and the results showed that triorganotin(IV) complex 6 has the lowest IC50 value. Also complexes 1–6 were studied for their in vitro cytotoxicity against sarcoma cancer cells (mesenchymal tissue) from the Wistar rat, and the results showed that the complexes have high activity against these cell lines with triphenyltin((IV) complex 4 to be the most active one

Synthesis, spectroscopic characterization, and crystal structures of two chlorodiorganotin(IV) 4-(2-methoxyphenyl)piperazine-1-carbodithioates

Two chlorodiorganotin(IV) complexes of 4-(2-methoxyphenyl)piperazine-1-carbodithioate (MPPDA) have been synthesized by 1:1 mole-ratio reactions of the parent acid (MPPDAH) with Me2SnCl2 or Et2SnCl2 in dry methanol. The products have been characterized by Raman and multinuclear NMR (H-1, C-13 and Sn-119) spectroscopy, elemental analysis, and mass spectrometry. Single-crystal X-ray diffraction studies indicate that both complexes have distorted trigonal bipyramidal geometries around the central Sn atom. (C) 2008 Elsevier B.V. All rights reserved

Thermal decomposition studies of the polyhedral oligomeric silsesquioxane, POSSh, and when it is impregnated with the metallocene bis(η5-cyclopentadienyl)zirconium(IV) dichloride or immobilized on silica

Thermal decomposition studies of the free polyhedral oligomeric silsesquioxane, POSSh, and when this species has been impregnated with Cp2ZrCl2 (Cp = 5-C5H5) or immobilized on SiO2 were conducted using infrared emission spectroscopy (IES) over a 100-1000 oC temperature range and by thermogravimetric analysis (TGA). The organic groups in POSSh apparently decompose thermally into Si-CH3, Si-H and other fragments. Upon impregnation with Cp2ZrCl2 however, a different thermal decomposition pathway was followed and new infrared emission bands appeared in the 1000-900 cm-1 region suggesting the formation of Si-O-Zr moieties. When immobilized on SiO2 and subjected to thermal decomposition, the POSSh species lost its organic groups and the inorganic structure remaining was incorporated into the SiO2 framework

CCDC 664574: Experimental Crystal Structure Determination

Related Article: Zia-ur-Rehman, M.M.Barsan, I.Wharf, N.Muhammad, S.Ali, A.Meetsma, I.S.Butler|2008|Inorg.Chim.Acta|361|3322|doi:10.1016/j.ica.2008.05.006,An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

CCDC 664573: Experimental Crystal Structure Determination

Related Article: Zia-ur-Rehman, M.M.Barsan, I.Wharf, N.Muhammad, S.Ali, A.Meetsma, I.S.Butler|2008|Inorg.Chim.Acta|361|3322|doi:10.1016/j.ica.2008.05.006,An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Raman, FTIR, Photoacoustic-Infrared, and Inelastic Neutron Scattering Spectra of Ternary Metal Hydride Salts A₂MH₅, (A = Ca, Sr, Eu; M = Ir, Rh) and Their Deuterides

The vibrational spectra of the ternary metal hydride (deuteride) salts, A₂MH₅ and A₂MD₅, where A = calcium, strontium and europium and M = iridium­(I) and rhodium­(I), have been assigned using Raman, Fourier transform infrared, photoacoustic infrared, and inelastic neutron scattering spectroscopies and density functional theory (DFT) calculations. The wavenumbers of the infrared-active stretching vibrations depend upon the ionization energies of the central metal atom and the cation. The phase transition in calcium pentahydridoiridate­(I) was studied as a function of temperature and pressure