Technetium-99m metastable radiochemistry for pharmaceutical applications: old chemistry for new products

###EgeUn###Radiopharmacy is a pharmaceutical specialty responsible for the development and production of radiopharmaceuticals. Radiopharmaceuticals are radioactive drugs, which can be used in two distinct manners: first for diagnosis in oncological, neurological and cardiac diseases, and second for therapy in oncology. Given their great specificity and precision, radiopharmaceuticals are among the most technological products in the field of pharmacy. Among radiopharmaceuticals, radiopharmaceuticals based on Tc-99m are the most widely used in the world. However, radiopharmacy and radiopharmaceuticals are still restricted to a few research centers in the world today. This is largely due to the difficulty in obtaining the radioactive material, the precursor of the radiopharmaceutical, as well as the understanding of the chemistry involved in these materials. In this sense, this study addresses the radiochemistry of radiopharmaceuticals based on Tc-99m as well as the coordination chemistry of these compounds. Finally, this review addresses the pharmaceutical aspects of Tc-99m radiopharmaceuticals.National Scientific and Technological Research Council (CNPQ)National Council for Scientific and Technological Development (CNPq); Rio de Janeiro State Research Foundation (FAPERJ)Carlos Chagas Filho Foundation for Research Support of the State of Rio de Janeiro (FAPERJ); CAPESCAPESThe authors would like to thank the National Scientific and Technological Research Council (CNPQ), the Rio de Janeiro State Research Foundation (FAPERJ) and CAPES for funding

Consumo e digestibilidade dos nutrientes em cabras Moxotó recebendo dietas com diferentes níveis de feno de maniçoba Intake and digestibility of nutrients in Moxotó dairy goats fed diets with different Maniçoba hay levels

Objetivou-se com este trabalho avaliar a utilização do feno de maniçoba (Manihot glaziovii Muell. Arg.) em diferentes níveis (30, 40, 50 e 60%) sobre os consumos e as digestibilidades de matéria seca (MS), matéria orgânica (MO), proteína bruta (PB), energia bruta (EB), extrato etéreo (EE), carboidratos totais (CT), carboidratos não-fibrosos (CNF), fibra em detergente neutro (FDN) e fibra em detergente ácido (FDA) e os consumos de água e nutrientes digestíveis totais (NDT). Utilizaram-se oito cabras da raça Moxotó, multíparas, com aproximadamente 60 dias de lactação, pesando 44,26 ± 4,23 kg, em delineamento quadrado latino duplo 4 × 4, com quatro tratamentos, quatro períodos e quatro animais. Cada período teve duração de 15 dias (10 de adaptação dos animais às dietas e 5 para coleta de dados). Utilizou-se a fibra em detergente ácido indigestível (FDAi) como indicador interno para estimativa da produção de matéria seca fecal. A utilização do feno de maniçoba nos níveis de 30, 40, 50 e 60% nas dietas para cabras em lactação não alterou os consumos de MS, MO, PB, EE, MM e CT. Os consumos de CNF, NDT e água diminuíram linearmente com o aumento no nível de feno de maniçoba nas dietas, enquanto os de FDN e FDA (kg/dia, %PC e g/kg0,75) aumentaram linearmente. A digestibilidade aparente de MS, MO, PB, EE, CT, CNF, EB e FDA reduziu linearmente, enquanto a da FDN não se alterou com o aumento dos níveis de feno na dieta.<br>This research was conducted with the objective of evaluating the use of different Maniçoba hay (Manihot glaziovii Muell. Arg) levels (30, 40, 50 and 60%) on intake and apparent digestibility of dry matter (DM), organic matter (OM), crude protein (CP), gross energy (GE), ether extract (EE), total carbohydrates (TCHT), non fiber carbohydrates (NFC), neutral detergent fiber (NDF), acid detergent fiber (ADF), water intake (WI), besides total digestible nutrients intake (TDNI). Eight multiparous Moxotó dairy goats with initial weight of 44,26 ± 4,23 kg were assigned to two 4 × 4 Latin squares design, with four treatments, four experimental periods and four animals. Each experimental period lasted 15 days (ten days for animal adaptation to diets and five days for feed, refusal and feces collection. Indigestible acid detergent fiber (iADF) was used as an internal marker to estimate fecal dry matter yield. The use of Maniçoba hay in the levels (30, 40, 50 and 60%) in diets did not affect the DM, OM, CP, EE, MM, and TCHT intakes. The NFC, TDN and water intakes decreased linearly with the increase of dietary hay levels while NDF and ADF (kg/day; %BW and g/kg0.75) intakes increased linearly. The apparent DM, OM, CP, EE, CHT, NFC, GE and ADF digestibility decreased linearly while the NDF digestibility was not affected with the increase in the dietary hay levels