796 research outputs found
Assumptionitis in Strategy
17 USC 105 interim-entered record; under review.The article of record as published may be found at https://thestrategybridge.org/the-bridge/2021/6/21/assumptionitis-in-strategyU.S. Government affiliation is unstated in article text
Revisiting the Zingiberales: Using Multiplexed Exon Capture to Resolve Ancient and Recent Phylogenetic Splits in a Charismatic Plant Lineage
The Zingiberales are an iconic order of monocotyledonous plants comprising eight families with distinctive and diverse floral morphologies and representing an important ecological element of tropical and subtropical forests. While the eight families are demonstrated to be monophyletic, phylogenetic relationships among these families remain unresolved. Neither combined morphological and molecular studies nor recent attempts to resolve family relationships using sequence data from whole plastomes has resulted in a well-supported, family-level phylogenetic hypothesis of relationships. Here we approach this challenge by leveraging the complete genome of one member of the order, Musa acuminata, together with transcriptome information from each of the other seven families to design a set of nuclear loci that can be enriched from highly divergent taxa with a single array-based capture of indexed genomic DNA. A total of 494 exons from 418 nuclear genes were captured for 53 ingroup taxa. The entire plastid genome was also captured for the same 53 taxa. Of the total genes captured, 308 nuclear and 68 plastid genes were used for phylogenetic estimation. The concatenated plastid and nuclear dataset supports the position of Musaceae as sister to the remaining seven families. Moreover, the combined dataset recovers known intra- and inter-family phylogenetic relationships with generally high bootstrap support. This is a flexible and cost effective method that gives the broader plant biology community a tool for generating phylogenomic scale sequence data in non-model systems at varying evolutionary depths
Gyrokinetic simulations of the tearing instability
Linear gyrokinetic simulations covering the collisional -- collisionless
transitional regime of the tearing instability are performed. It is shown that
the growth rate scaling with collisionality agrees well with that predicted by
a two-fluid theory for a low plasma beta case in which ion kinetic dynamics are
negligible. Electron wave-particle interactions (Landau damping), finite Larmor
radius, and other kinetic effects invalidate the fluid theory in the
collisionless regime, in which a general non-polytropic equation of state for
pressure (temperature) perturbations should be considered. We also vary the
ratio of the background ion to electron temperatures, and show that the
scalings expected from existing calculations can be recovered, but only in the
limit of very low beta.Comment: 7 pages, 10 figures, submitted to Po
Synthetic Compound Libraries Displayed on the Surface of Encoded Bacteriophage
AbstractWe describe a technology for attaching libraries of synthetic compounds to coat proteins of bacteriophage particles such that the identity of the chemical structure is encoded in the genome of the phage, analogous to peptides displayed on phage surfaces by conventional phage-display techniques. This format allows a library of synthetic compounds to be screened very efficiently as a single pool. Encoded phage serve as extremely robust reporters of the presence of each compound, providing exquisite sensitivity for identification of active compounds engaged in complex biological processes such as receptor-mediated endocytosis and transcytosis. To evaluate this approach, we constructed a library of 980 analogs of folic acid displayed on T7 phage, and demonstrated rapid identification of compounds that bind to folate receptor and direct endocytosis of associated phage particles into cells that express the targeted receptor
Disrupted seasonal biology impacts health, food security and ecosystems
The rhythm of life on earth is shaped by seasonal changes in the environment. Plants and animals show profound annual cycles in physiology, health, morphology, behaviour and demography in response to environmental cues. Seasonal biology impacts ecosystems and agriculture, with consequences for humans and biodiversity. Human populations show robust annual rhythms in health and well-being, and the birth month can have lasting effects that persist throughout life. This review emphasizes the need for a better understanding of seasonal biology against the backdrop of its rapidly progressing disruption through climate change, human lifestyles and other anthropogenic impact. Climate change is modifying annual rhythms to which numerous organisms have adapted, with potential consequences for industries relating to health, ecosystems and food security. Disconcertingly, human lifestyles under artificial conditions of eternal summer provide the most extreme example for disconnect from natural seasons, making humans vulnerable to increased morbidity and mortality. In this review, we introduce scenarios of seasonal disruption, highlight key aspects of seasonal biology and summarize from biomedical, anthropological, veterinary, agricultural and environmental perspectives the recent evidence for seasonal desynchronization between environmental factors and internal rhythms. Because annual rhythms are pervasive across biological systems, they provide a common framework for trans-disciplinary research
Integration of highly probabilistic sources into optical quantum architectures: perpetual quantum computation
In this paper we introduce a design for an optical topological cluster state
computer constructed exclusively from a single quantum component. Unlike
previous efforts we eliminate the need for on demand, high fidelity photon
sources and detectors and replace them with the same device utilised to create
photon/photon entanglement. This introduces highly probabilistic elements into
the optical architecture while maintaining complete specificity of the
structure and operation for a large scale computer. Photons in this system are
continually recycled back into the preparation network, allowing for a
arbitrarily deep 3D cluster to be prepared using a comparatively small number
of photonic qubits and consequently the elimination of high frequency,
deterministic photon sources.Comment: 19 pages, 13 Figs (2 Appendices with additional Figs.). Comments
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Radio Astronomy
Contains reports on twelve research projects.National Science Foundation (Grant AST77-06052)Joint Services Electronics Program (Contract DAAB07-76-C-1400)National Aeronautics and Space Administration (Contract NAS5-21980)U.S. Air Force - Electronic Systems Division (Contract F19628-75-C-0122)U.S. Department of Commerce - National Oceanic Atmospheric Administration (Grant 04-8-M01-1)National Aeronautics and Space Administration (Contract NAS5-22929)National Aeronautics and Space Administration (Contract NAS5-23677)National Science Foundation (Grant AST73-05042-A03)National Science Foundation (Grant AST76-20376
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