Demographic and cognitive profile of individuals seeking a diagnosis of Autism Spectrum Disorder in adulthood

Little is known about ageing with autism spectrum disorder (ASD). We examined the characteristics of adults referred to a specialist diagnostic centre for assessment of possible ASD, 100 of whom received an ASD diagnosis and 46 did not. Few demographic differences were noted between the groups. Comorbid psychiatric disorders were high in individuals with ASD (58%) and non-ASD (59%). Individuals who received an ASD diagnosis had higher self-rated severity of ASD traits than non-ASD individuals. Within the ASD group, older age was associated with higher ratings of ASD traits and better cognitive performance. One interpretation is that general cognitive ability and the development of coping strategies across the lifespan, do not necessarily reduce ASD traits but may mitigate their effects

Crop Updates 2008 - Weeds

This session covers twenty nine papers from different authors: 1. BOXER® GOLD, a new pre-emergent herbicide option for WA wheat and barley growers for the control of Annual Ryegrass and Toad Rush, Craig A. Ruchs, Syngenta Crop Protection Australia Pty Ltd 2. Efficacy of Boxer Gold in the control of annual ryegrass in wheat, Dr Abul Hashem, Dr Catherine Borger, Department of Agriculture and Food, Mr Ken McKee, Field Development Manager, Syngenta Crop Protection Australia Pty Ltd 3. Alternative herbicides to avoid trifluralin resistance, Catherine Borger and Abul Hashem, Department of Agriculture and Food 4. Exiting new herbicides for ryegrass control in wheat, Peter Newman, Department of Agriculture and Food 5. Herbicide options for resistant wild radish in wheat, Peter Newman, Department of Agriculture and Food 6. A near-complete control of wild radish with three new herbicide products, Aik Cheam and Siew Lee, Department of Agriculture and Food 7. An investigation of diflufenican resistance mechanism/s in wild radish, Meagan Pearce, Dr Michael Walsh and Prof. Stephen Powles, Western Australian Herbicide Resistance Initiative, School of Plant Biology, University of WA 8. Synergistic effects of Group C and GroupF herbicides on resistant and susceptible wild radish populations, Kent Stone, Dr Michael Walsh and Prof. Stephen Powles, Western Australian Herbicide Resistance Initiative, School of Plant Biology, University of WA 9. Precept® for the management of wild radish resistant to PDS inhibiting herbicides, Mike Clarke and Andrew Loorham, Bayer Cropscience Pty Ltd, Dr Michael Walsh, WAHRI, University of Western Australia 10. Evolution of glyphosate resistance in annual ryegrass: Effects of cutting rates, Roberto Busi and Stephen B. Powles, Western Australian Herbicide Resistance Initiative, School of Plant Biology, The University of Western Australia 11. Metribuzin and other herbicides pre-sowing of lupins, Peter Newman, Department of Agriculture and Food 12. Crop topping lupins with glufosinate gives poor control of ryegrass seed set, Peter Newman, Department of Agriculture and Food 13. Brome grass has developed multiple resistance to Group B and C herbicides, Dr Abul Hashem, Dr Catherine Borger and Dr Shahab Pathan, Department of Agriculture and Food 14. Effect of sowing methods, Logran® and Metribuzin on weeds and wheat grain yield, Alexandra Douglas and Abul Hashem, Department of Agriculture and Food 15. Effect of alternative Group K herbicides on control of on-row annual ryegrass in wide row lupins, Dr Abul Hashem1, Ray Fulwood2 and Chris Roberts1, 1Department of Agriculture and Food, 2Farmer, Meckering, Western Australia 16. Control and seed production of annual ryegrass in wide row lupins within the Western Australian wheatbelt, Abul Hashem1,6, Alex Douglas1,6, Shahab Pathan1, Glen Riethmuller1,6 and 1,6Sally Peltzer, Department of Agriculture and Food, 6CRC Australian Weed Management 17. Effective weed control in wide row lupins, Glen Riethmuller, Abul Hashem and Shahab Pathan, Department of Agriculture and Food, and CRC Australian Weed Management 18. Slender iceplant control, Lorinda Hunt1, John Borger1, Meir Altman1,4 and Dr Ed Barrett-Lennard1,4, Department of Agriculture and Food, Western Australia1, University of Western Australia and Future Farm Industries CRC4 19. Chemical and non-chemical weed control – a European perspective, Glen Riethmuller, Department of Agriculture and Food 20. Mouldboard ploughing shows promise on sand, Peter Newman, Stephen Davies and Sally Peltzer, Department of Agriculture and Food 21. Weed seed head trimming, Glen Riethmuller and Abul Hashem, Department of Agriculture and Food 22. A survey of summer weed incidence and distribution across the WA wheatbelt, Pippa Michaela, Bill McLeodb, Catherine Borgerb and Alex Douglasb, aCurtin University of Technology, bDepartment of Agriculture and Food 23. Herbicide tolerance of field pea varieties, Harmohinder Dhammu and Mark Seymour, Department of Agriculture and Food 24. Herbicide tolerance of current/new wheat varieties, Dr Harmohinder Dhammu, Department of Agriculture and Food 25. Herbicide tolerance of new oat varieties, Harmohinder Dhammu, Vince Lambert and Chris Roberts, Department of Agriculture and Food 26. Herbicide tolerance of saltbush and bluebush, Lorinda Hunt1, John Borger1, Meir Altman1,4 and Dr Ed Barrett-Lennard1,4, Department of Agriculture and Food1, University of Western Australia and Future Farm Industries CRC4 27. A review of 2,4-D formulations and vapour drift, John H. Moore, Department of Agriculture and Food 28. Movement of 2,4-D butyl ester and the dose response of three formulations of 2,4-D on canola, John H. Moore, Department of Agriculture and Food 29. Pathways to registration – Improving pesticide research outcomes, Dr Rohan Rainbow, Manager Crop Protection, Grains Research and Development Corporatio

Crop Updates 2002 - Weeds

This session covers fifty eight papers from different authors: 1. INTRODUCTION Vanessa Stewart, DEPARTMENT OF AGRICULTURE INTEGRATED WEED MANAGEMENT IWM system studies / demonstration sites 2. Major outcomes from IWM demonstration sites, Alexandra Douglas Department of Agriculture 3. Integrated weed management: Katanning, Alexandra Douglas Department of Agriculture 4. Integrated weed management: Merredin, Vanessa Stewart Department of Agriculture 5. Long term resistance site: Get ryegrass numbers low and keep them low! Peter Newman and Glen Adams Department of Agriculture 6. Using pastures to manage ryegrass populations, Andrew Blake and Natalie Lauritsen Department of Agriculture Weed biology and competition 7. Understanding the weed seed bank life if important agricultural weeds, Sally Peltzer and Paul Matson Department of Agriculture 8. Consequence of radish competition on lupin nutrients in wheat-lupin rotation, Abul Hashem and Nerys Wilkins Department of Agriculture 9. Consequence of ryegrass competition on lupin nutrients in a wheat-lupin rotation, Abul Hashem and Nerys Wilkins Department of Agriculture 10. Brome grass too competitive for early sown wheat in a dry year at Mullewa, Peter Newman and Glenn Adam Department of Agriculture Crop establishment and weed management 11. Seeding rate, row spacing and herbicides for weed control, David Minkey Department of Agriculture 12. Effect of different seeding methods on wheat and ryegrass, Abul Hashem, Glen Riethmuller and Nerys Wilkins Department of Agriculture 13. Role of tillage implements and trifluralin on the effectiveness of the autumn tickle for stimulating annual ryegrass emergence, Tim Cusack1, Kathryn Steadman1 and Abul Hashem2,1Western Australia Herbicide Resistance Initiative, UWA; 2Department of Agriculture, 14. Timing of autumn tickle in important for non-wetting soils, Pippa Michael1, Peter Newman2 and Kathryn Steadman 2, 1Western Australia Herbicide Resistance Initiative, UWA, 2Department of Agriculture 15. Early investigation into weed seed burial by mouldboard plough, Sally Peltzer and Alex Douglas Department of Agriculture 16. Rolling post-emergent lupins to improve weed emergence and control on loamy sand, Paul Blackwell, Department of Agriculture and Dave Brindal, Strawberry via Mingenew IWM tools 17. Crop topping in 2001: How did we do? Peter Newman and Glenn Adam Department of Agriculture 18. Wickwipers work! Peter Newman and Glenn Adam Department of Agriculture 19. Wild radish and ryegrass seed collection at harvest: Chaff carts and other devices, Michael Walsh Western Australia Herbicide Resistance Initiative, UWA and Wayne Parker Department of Agriculture 20. Improving weed control in grazed pastures using legumes with low palatability, Clinton Revell, Giles Glasson Department of Agriculture, and Dean Thomas Faculty of Agriculture, University of Western Australia Adoption and modelling 21. Grower weed survey, Peter Newman and Glenn Adam Department of Agriculture 22. Agronomist survey, Peter Newman and Glenn Adam Department of Agriculture 23. Ryegrass RIM model stands the test of IWM field trial data, Alister Draper Western Australia Herbicide Resistance Initiative, UWA and Bill Roy, Western Australia Herbicide Resistance Initiative, UWA Agricultural Consulting and Research Services 24. Multi-species RIM: An update, Marta Monjardin1,2, David Pannell2 and Stephen Powles 1, 1Western Australia Herbicide Resistance Initiative, UWA, 2 ARE, University of Western Australia 25. RIM survey feedback, Robert Barrett-Lennard and Alister Draper Western Australia Herbicide Resistance Initiative, UWA 26. Effect of historic input and product prices on choice of ryegrass management strategies, Alister Draper1 and Martin Bent2, 1Western Australia Herbicide Resistance Initiative, UWA, 2Muresk Institute of Agriculture 27. Living with ryegrass – trading off weed control and economic performance, Martin Bent1 and Alister Draper2 , 1Muresk Institute of Agriculture, Curtin University, 2Western Australia Herbicide Resistance Initiative, UWA HERBICIDE RESISTANCE 28. Glyphosate resistance in WA and Australia: Where are we at? Paul Neve1, Art Diggle2, Patrick Smith3, Mechelle Owen1, Abul Hashem2, Christopher Preston4and Stephen Powles1,1Western Australian Herbicide Resistance Initiative, University of Western Australia, 2Department of Agriculture, 3CSIRO Sustainable Ecosystems, 4CRC for Australian Weed Management and Department of Applied and Molecular Ecology, Waite Campus, University of Adelaide 29. We need you weeds: A survey of knockdown resistance in the WA wheatbelt, Paul Neve1, Mechelle Owen1, Abul Hashem2 and Stephen Powles1 1Western Australian Herbicide Resistance Initiative, University of Western Australia, 2Department of Agriculture 30. A test for resistance testing, Mechelle Owen, Tracey Gillam, Rick Llewellyn and Steve Powles,Western Australia Herbicide Resistance Initiative, University of Western Australia 31. In field testing for herbicide resistance, a purpose built multi-treatment spray boom with results from 2001, Richard Quinlan, Elders Ltd 32. Advantages and limitations of a purpose built multi-treatment spray boom, Richard Quinlan, Elders Ltd 33. Group F resistant wild radish: What’s new? Aik Cheam, Siew Lee Department of Agriculture, and Mike Clarke Aventis Crop Science 34. Cross resistance of Brodal® resistant wild radish to Sniper®, Aik Cheam and Siew Lee, Department of Agriculture 35. Managing a biotype of wild radish with Group F and Group C resistance, Aik Cheam, Siew Lee, David Nicholson, Peter Newman Department of Agriculture and Mike Clarke, Aventis Crop Science HERBICIDE TOLERANCE 36. Herbicide tolerance of new wheat varieties, Harmohinder S. Dhammu, Terry Piper and David Nicholson, Agriculture Western Australia 37. Response of barley varieties to herbicides, Harmohinder S. Dhammu, Terry Piper, Department of Agriculture 38. Tolerance of barley to phenoxy herbicides, Harmohinder S. Dhammu, Terry Piper, Department of Agriculture and Chad Sayer, Nufarm Australia Limited 39. Response of Durum wheats to herbicides, Harmohinder S. Dhammu, Terry Piper, Department of Agriculture 40. Response of new field pea varieties to herbicides, Harmohinder S. Dhammu, Terry Piper and David Nicholson, Department of Agriculture 41. Herbicide tolerance of Desi chickpeas on marginal soil, Harmohinder S. Dhammu, Terry Piper and David Nicholson, Department of Agriculture 42. Herbicide tolerance of newer lupin varieties, Terry Piper, Harmohinder Dhammu and David Nicholson, Department of Agriculture 43. Herbicide tolerance of some annual pasture legumes, Clinton Revell and Ian Rose, Department of Agriculture 44. Herbicide tolerance of pasture legumes, Andrew Blake, Department of Agriculture HERBICIDES – NEW PRODUCTS/PRODUCT USES; USE 45. Knockdown herbicides do not reliably kill small grass weeds, Peter Newman and Glenn Adam, Department of Agriculture 46. ‘Hair Cutting’ wheat with Spray.Seed®: Does it work? Peter Newman and Glenn Adam, Department of Agriculture 47. ‘Haircutting’: Does the number one cut work? Robert Barrett-Lennard1 and Jerome Critch2,1WA Herbicide Resistance Initiative, University of WA, 2Student, University of WA 48. Hammer EC (Carfentrazone-ethyl): A mixing partner for glyphosate to enhance the control of difficult broadleaf weeds, Gordon R. Cumming, Crop Care Australasia 49. Marshmallow control in reduced tillage systems, Sam Taylor, Wesfarmers Landmark 50. Herbicide options for summer germinating marshmallow, Vanessa Stewart, Department of Agriculture 51. Dual Gold® safe in a dry year at Coorow, Peter Newman and Glenn Adam, Department of Agriculture 52. The effect of glyphosate, paraquat and diquat as a crop topping application on the germination of barley, John Moore and Roslyn Jettner, Department of Agriculture 53. Herbicide options for melon control, Vanessa Stewart, Department of Agriculture 54. Herbicide options for the control of Chloris truncate (windmill grass) Vanessa Stewart, Department of Agriculture 55. Allelopathic effects of crop, pasture and weed residues on subsequent crop and pasture establishment, Stuart Bee1, Lionel Martin1, Keith Devenish2 and Terry Piper2, 1Muresk Institute of Agriculture, Curtin University of Technology, Northam, Western Australia, 2Centre for Cropping Systems, Department of Agriculture WEED ISSUES 56. Role of Roundup ReadyÒ canola in the farming system, Art Diggle1, Patrick Smith2, Paul Neve3, Felicity Flugge4, Amir Abadi5 and Stephen Powles3, 1Department of Agriculture; 2CSIRO, Sustainable Ecosystems; 3Western Australian Herbicide Resistance Initiative; 4Centre for Legumes in Mediterranean Agriculture; 5Touchstone Consulting 57. ’Weeds for Feed’ and livestock enterprise structures: A feasibility study and farmer survey in the north-easern wheatbelt, Duncan Peter and Stuart McAlpine, Department of Agriculture and Liebe Group, Buntine 58. e-weed, Vanessa Stewart, Agriculture Western Australi

Developmental expression of orphan g protein-coupled receptor 50 in the mouse brain

[Image: see text] Mental disorders have a complex etiology resulting from interactions between multiple genetic risk factors and stressful life events. Orphan G protein-coupled receptor 50 (GPR50) has been identified as a genetic risk factor for bipolar disorder and major depression in women, and there is additional genetic and functional evidence linking GPR50 to neurite outgrowth, lipid metabolism, and adaptive thermogenesis and torpor. However, in the absence of a ligand, a specific function has not been identified. Adult GPR50 expression has previously been reported in brain regions controlling the HPA axis, but its developmental expression is unknown. In this study, we performed extensive expression analysis of GPR50 and three protein interactors using rt-PCR and immunohistochemistry in the developing and adult mouse brain. Gpr50 is expressed at embryonic day 13 (E13), peaks at E18, and is predominantly expressed by neurons. Additionally we identified novel regions of Gpr50 expression, including brain stem nuclei involved in neurotransmitter signaling: the locus coeruleus, substantia nigra, and raphe nuclei, as well as nuclei involved in metabolic homeostasis. Gpr50 colocalizes with yeast-two-hybrid interactors Nogo-A, Abca2, and Cdh8 in the hypothalamus, amygdala, cortex, and selected brain stem nuclei at E18 and in the adult. With this study, we identify a link between GPR50 and neurotransmitter signaling and strengthen a likely role in stress response and energy homeostasis

Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial

SummaryBackground Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatoryactions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID-19.Methods In this randomised, controlled, open-label, adaptive platform trial (Randomised Evaluation of COVID-19Therapy [RECOVERY]), several possible treatments were compared with usual care in patients admitted to hospitalwith COVID-19 in the UK. The trial is underway at 176 hospitals in the UK. Eligible and consenting patients wererandomly allocated to either usual standard of care alone or usual standard of care plus azithromycin 500 mg once perday by mouth or intravenously for 10 days or until discharge (or allocation to one of the other RECOVERY treatmentgroups). Patients were assigned via web-based simple (unstratified) randomisation with allocation concealment andwere twice as likely to be randomly assigned to usual care than to any of the active treatment groups. Participants andlocal study staff were not masked to the allocated treatment, but all others involved in the trial were masked to theoutcome data during the trial. The primary outcome was 28-day all-cause mortality, assessed in the intention-to-treatpopulation. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936.Findings Between April 7 and Nov 27, 2020, of 16 442 patients enrolled in the RECOVERY trial, 9433 (57%) wereeligible and 7763 were included in the assessment of azithromycin. The mean age of these study participants was65·3 years (SD 15·7) and approximately a third were women (2944 [38%] of 7763). 2582 patients were randomlyallocated to receive azithromycin and 5181 patients were randomly allocated to usual care alone. Overall,561 (22%) patients allocated to azithromycin and 1162 (22%) patients allocated to usual care died within 28 days(rate ratio 0·97, 95% CI 0·87–1·07; p=0·50). No significant difference was seen in duration of hospital stay (median10 days [IQR 5 to >28] vs 11 days [5 to >28]) or the proportion of patients discharged from hospital alive within 28 days(rate ratio 1·04, 95% CI 0·98–1·10; p=0·19). Among those not on invasive mechanical ventilation at baseline, nosignificant difference was seen in the proportion meeting the composite endpoint of invasive mechanical ventilationor death (risk ratio 0·95, 95% CI 0·87–1·03; p=0·24).Interpretation In patients admitted to hospital with COVID-19, azithromycin did not improve survival or otherprespecified clinical outcomes. Azithromycin use in patients admitted to hospital with COVID-19 should be restrictedto patients in whom there is a clear antimicrobial indication

Friendship in young people with Asperger's syndrome

The understanding and experiences of twenty young people with Asperger's syndrome (AS) were compared with those of nineteen age-matched neurotypical young people. The participants were aged between eleven and nineteen years of age. They were asked: first, to define "a friend"; second, to say whether or not they thought that friends were important; third, to complete a questionnaire that asked about what they did with their friends; and fourth, to rate the behaviours of two friends in each of six story vignettes. Supplementary information was obtained by means of a brief semi-structured interview with each of the participants and, about the Asperger's group, by means of questionnaires completed by some of their parents and staff It was found that, whilst the definitions of friendship that the AS group gave were similar in content to those of the neurotypical group, some, at least, had a rather theoretical quality. Although most of the AS group thought that friendships were important, significantly fewer of them than of the neurotypical group mentioned the importance of companionship in explaining why. Responses to the friendship questionnaire suggested that there were differences between the two groups in terms of the security of their friendships, that is the extent to which they felt able to rely upon their friends and to transcend any differences arising. There were significant between-group differences in the responses to five of the six friendship vignettes, suggesting that young people with AS have a different perspective on what is and is not appropriate social behaviour. Information from the semi-structured interviews and the parent and staff questionnaires was used to provide illustrations of the between-groups differences that emerged and also to highlight instances where the formal measures perhaps failed to access fully the lived experience of the young people with AS. The difficulties that the AS group faced in forming and maintaining friendships were explored, with a view to considering how their friendships could best be supported. Directions for future research were suggested and possible methodologies were considered

Zur Messung von Staat-Kirche-Beziehungen. Eine vergleichende Analyse neuerer Indizes

Im Zuge der erhöhten Aufmerksamkeit, welche dem Faktor Religion in der Politik zuteil wird, ist das spannungsreiche Verhältnis von Staat und Kirche wieder vermehrt in den Blick geraten. Gleichwohl werden bisherige Forschungsbemühungen der quantitativ-vergleichenden Politikwissenschaft oftmals durch einen Mangel an geeigneten Messkonzepten gehemmt. Erst in allerjüngster Zeit sind verschiedene Vorschläge zur Messung von Staat-Kirche-Beziehungen hervorgebracht worden. Ziel des vorliegenden Beitrags ist es, diese neuen Messvorschläge vorzustellen und in einem kritischen Vergleich ihre jeweiligen methodischen Stärken und Schwächen herauszuarbeiten. Genauer gesprochen wird der Versuch unternommen, den von Munck und Verkuilen (Comparative Political Studies 35:5–24, 2002) im Rahmen der Demokratiemessung vorgeschlagenen und von Müller und Pickel (Politische Vierteljahresschrift 48:511–539, 2007) präzisierten Kriterienkatalog zur methodologischen Bewertung von Messkonzepten auf insgesamt fünf verschiedene Indizes zur Messung von Staat-Kirche-Verflechtungen anzuwenden. Konkret wird dabei anhand spezifischer Beurteilungskriterien untersucht, inwieweit die methodischen Herausforderungen der Konzeptualisierung, der Messung sowie der Aggregation bei der Konstruktion der betrachteten Indizes überzeugend bewältigt wurden. Neben der vergleichenden Analyse und Bewertung von neuen Messinstrumenten wird damit gleichzeitig die Brauchbarkeit dieses Evaluationsschemas, sowie seine Übertragbarkeit in alternative Anwendungskontexte erprobt