1,230 research outputs found
Mandated Benefits, Welfare, and Heterogeneous Firms
The paper constructs an asymmetric information model to investigate the efficiency and equity cases for government mandated benefits. A mandate can improve workers' insurance, and may also redistribute in favor of more "deserving" workers. The risk is that it may also reduce output. The more diverse are free market contracts - separating the various worker types - the more likely it is that such output effects will on balance serve to reduce welfare. It is shown that adverse effects can be mitigated by restricting mandates to "large" firms. An alternative to a mandate is direct government provision. We demonstrate that direct government provision may be superior to mandates by virtue of preserving separations
Computational prediction of the Crc regulon identifies genus-wide and species-specific targets of catabolite repression control in Pseudomonas bacteria
<p>Abstract</p> <p>Background</p> <p>Catabolite repression control (CRC) is an important global control system in <it>Pseudomonas </it>that fine tunes metabolism in order optimise growth and metabolism in a range of different environments. The mechanism of CRC in <it>Pseudomonas </it>spp. centres on the binding of a protein, Crc, to an A-rich motif on the 5' end of an mRNA resulting in translational down-regulation of target genes. Despite the identification of several Crc targets in <it>Pseudomonas </it>spp. the Crc regulon has remained largely unexplored.</p> <p>Results</p> <p>In order to predict direct targets of Crc, we used a bioinformatics approach based on detection of A-rich motifs near the initiation of translation of all protein-encoding genes in twelve fully sequenced <it>Pseudomonas </it>genomes. As expected, our data predict that genes related to the utilisation of less preferred nutrients, such as some carbohydrates, nitrogen sources and aromatic carbon compounds are targets of Crc. A general trend in this analysis is that the regulation of transporters is conserved across species whereas regulation of specific enzymatic steps or transcriptional activators are often conserved only within a species. Interestingly, some nucleoid associated proteins (NAPs) such as HU and IHF are predicted to be regulated by Crc. This finding indicates a possible role of Crc in indirect control over a subset of genes that depend on the DNA bending properties of NAPs for expression or repression. Finally, some virulence traits such as alginate and rhamnolipid production also appear to be regulated by Crc, which links nutritional status cues with the regulation of virulence traits.</p> <p>Conclusions</p> <p>Catabolite repression control regulates a broad spectrum of genes in <it>Pseudomonas</it>. Some targets are genus-wide and are typically related to central metabolism, whereas other targets are species-specific, or even unique to particular strains. Further study of these novel targets will enhance our understanding of how <it>Pseudomonas </it>bacteria integrate nutritional status cues with the regulation of traits that are of ecological, industrial and clinical importance.</p
Validation and preliminary data from a health-related quality of life questionnaire for owners of dogs with cardiac disease
BACKGROUND: Cardiac disease in dogs impacts the quality of life (QoL) of their owners, but owners\u27 QoL has not been comprehensively assessed in this population.
OBJECTIVES: To develop, validate, and provide preliminary data from a health-related QoL (hrQoL) questionnaire for owners of dogs with cardiac disease.
SUBJECTS: A total of 141 owners of dogs with cardiac disease were studied.
METHODS: An owner hrQoL (O-hrQoL) questionnaire containing 20 items related to areas of a person\u27s life that could be impacted by caring for a dog with cardiac disease was developed and administered to owners of dogs with cardiac disease. The highest possible total score was 100, with higher scores indicating a worse hrQoL. Readability, internal consistency, face and construct validity, and item-total correlations were assessed.
RESULTS: Median O-hrQoL score was 35 (range, 0-87). The questionnaire had good internal consistency (Cronbach\u27s alpha = 0.933), construct validity (Spearman\u27s r = 0.38-0.53; Kendall\u27s tau = 0.30-0.43; P \u3c .001), and item-total correlation (Spearman\u27s r = 0.44-0.79; Kendall\u27s tau = 0.34-0.66; all P \u3c .001). Fifty percent of owners indicated a negative effect of dogs\u27 cardiac disease on their own QoL, but all owners responded that caring for their dogs either had strengthened (n = 76; 53.9%) or had no effect on their relationship with their dog (n = 65; 46.1%).
CONCLUSIONS AND CLINICAL IMPORTANCE: The O-hrQoL questionnaire had good validity, and results suggest that owners\u27 QoL is significantly impacted by caring for dogs with cardiac disease. Additional research on effective approaches to minimizing the negative effects of a dog\u27s cardiac disease on the owner is warranted
A NuSTAR observation of the reflection spectrum of the low mass X-ray binary 4U 1728-34
We report on a simultaneous NuSTAR and Swift observation of the neutron star
low-mass X-ray binary 4U 1728-34. We identified and removed four Type I X-ray
bursts during the observation in order to study the persistent emission. The
continuum spectrum is hard and well described by a black body with 1.5
keV and a cutoff power law with 1.5 and a cutoff temperature of 25
keV. Residuals between 6 and 8 keV provide strong evidence of a broad Fe
K line. By modeling the spectrum with a relativistically blurred
reflection model, we find an upper limit for the inner disk radius of . Consequently we find that km,
assuming M=1.4{\mbox{\rm\,M_{\mathord\odot}}} and . We also find an
upper limit on the magnetic field of G.Comment: 9 pages, 8 figure
The smooth cyclotron line in Her X-1 as seen with NuSTAR
Her X-1, one of the brightest and best studied X-ray binaries, shows a
cyclotron resonant scattering feature (CRSF) near 37 keV. This makes it an
ideal target for detailed study with the Nuclear Spectroscopic Telescope Array
(NuSTAR), taking advantage of its excellent hard X-ray spectral resolution. We
observed Her X-1 three times, coordinated with Suzaku, during one of the high
flux intervals of its 35d super-orbital period. This paper focuses on the shape
and evolution of the hard X-ray spectrum. The broad-band spectra can be fitted
with a powerlaw with a high-energy cutoff, an iron line, and a CRSF. We find
that the CRSF has a very smooth and symmetric shape, in all observations and at
all pulse-phases. We compare the residuals of a line with a Gaussian optical
depth profile to a Lorentzian optical depth profile and find no significant
differences, strongly constraining the very smooth shape of the line. Even
though the line energy changes dramatically with pulse phase, we find that its
smooth shape does not. Additionally, our data show that the continuum is only
changing marginally between the three observations. These changes can be
explained with varying amounts of Thomson scattering in the hot corona of the
accretion disk. The average, luminosity-corrected CRSF energy is lower than in
past observations and follows a secular decline. The excellent data quality of
NuSTAR provides the best constraint on the CRSF energy to date.Comment: 13 pages, 13 figures, accepted for publication in Ap
Chandra and RXTE Spectra of the Burster GS 1826-238
Using simultaneous observations from Chandra and RXTE, we investigated the
LMXB GS 1826-238 with the goal of studying its spectral and timing properties.
The uninterrupted Chandra observation captured 6 bursts (RXTE saw 3 of the 6),
yielding a recurrence time of 3.54 +/- 0.03 hr. Using the proportional counter
array on board RXTE, we made a probable detection of 611 Hz burst oscillations
in the decaying phases of the bursts with an average rms signal amplitude of
4.8%. The integrated persistent emission spectrum can be described as the dual
Comptonization of ~ 0.3 keV soft photons by a plasma with kT_e ~ 20 keV and an
optical depth of about 2.6 (interpreted as emission from the accretion disk
corona), plus the Comptonization of hotter ~ 0.8 keV seed photons by a ~ 6.8
keV plasma (interpreted as emission from or near the boundary layer). We
discovered evidence for a neutral Fe K\alpha emission line, and we found
interstellar Fe L_II and Fe L_III absorption features. The burst spectrum can
be fit by fixing the disk Comptonization parameters to the persistent emission
best-fit values, and adding a blackbody. The blackbody/seed photon temperature
at the peak of the burst is ~ 1.8 keV and returns to ~ 0.8 keV over 200 s. The
blackbody radius is consistent with R_bb = 10.3-11.7 km assuming a distance of
6 kpc; however, by accounting for the fraction of the surface that is obscured
by the disk as a function of binary inclination, we determined the source
distance must actually be near 5 kpc in order for the stellar radius to lie
within the commonly assumed range of 10-12 km.Comment: Accepted for publication in ApJ; 13 pages, 6 figure
No Time for Dead Time: Timing analysis of bright black hole binaries with NuSTAR
Timing of high-count rate sources with the NuSTAR Small Explorer Mission
requires specialized analysis techniques. NuSTAR was primarily designed for
spectroscopic observations of sources with relatively low count-rates rather
than for timing analysis of bright objects. The instrumental dead time per
event is relatively long (~2.5 msec), and varies by a few percent
event-to-event. The most obvious effect is a distortion of the white noise
level in the power density spectrum (PDS) that cannot be modeled easily with
the standard techniques due to the variable nature of the dead time. In this
paper, we show that it is possible to exploit the presence of two completely
independent focal planes and use the cross power density spectrum to obtain a
good proxy of the white noise-subtracted PDS. Thereafter, one can use a Monte
Carlo approach to estimate the remaining effects of dead time, namely a
frequency-dependent modulation of the variance and a frequency-independent drop
of the sensitivity to variability. In this way, most of the standard timing
analysis can be performed, albeit with a sacrifice in signal to noise relative
to what would be achieved using more standard techniques. We apply this
technique to NuSTAR observations of the black hole binaries GX 339-4, Cyg X-1
and GRS 1915+105.Comment: 13 pages, 8 figures, submitted to Ap
Annular electroconvection with shear
We report experiments on convection driven by a radial electrical force in
suspended annular smectic A liquid crystal films. In the absence of an
externally imposed azimuthal shear, a stationary one-dimensional (1D) pattern
consisting of symmetric vortex pairs is formed via a supercritical transition
at the onset of convection. Shearing reduces the symmetries of the base state
and produces a traveling 1D pattern whose basic periodic unit is a pair of
asymmetric vortices. For a sufficiently large shear, the primary bifurcation
changes from supercritical to subcritical. We describe measurements of the
resulting hysteresis as a function of the shear at radius ratio . This simple pattern forming system has an unusual combination of
symmetries and control parameters and should be amenable to quantitative
theoretical analysis.Comment: 12 preprint pages, 3 figures in 2 parts each. For more info, see
http://mobydick.physics.utoronto.c
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