22,889 research outputs found
Barriers to recovery and recommendations for change: the Pennsylvania Consensus Conference on psychiatry\u27s role.
OBJECTIVE: Recovery has emerged over the past decade as a dominant theme in public mental health care.
METHODS: The 2006 Pennsylvania Consensus Conference brought together 24 community psychiatrists to explore the barriers they experienced in promoting recovery and their recommendations for change.
RESULTS: Twelve barriers were identified and classified into one of three categories: psychiatry knowledge, roles, and training; the need to transform public mental health systems and services; and environmental barriers to opportunity. Participants made 22 recommendations to address these barriers through changes in policies, programs, and psychiatric knowledge and practice.
CONCLUSIONS: The recommendations identify areas for change that can be accomplished through individual psychiatrist action and organized group efforts
Theoretical Clues to the Ultraviolet Diversity of Type Ia Supernovae
The effect of metallicity on the observed light of Type Ia supernovae (SNe
Ia) could lead to systematic errors as the absolute magnitudes of local and
distant SNe Ia are compared to measure luminosity distances and determine
cosmological parameters. The UV light may be especially sensitive to
metallicity, though different modeling methods disagree as to the magnitude,
wavelength dependence, and even the sign of the effect. The outer density
structure, ^56 Ni, and to a lesser degree asphericity, also impact the UV. We
compute synthetic photometry of various metallicity-dependent models and
compare to UV/optical photometry from the Swift Ultra-Violet/Optical Telescope.
We find that the scatter in the mid-UV to near-UV colors is larger than
predicted by changes in metallicity alone and is not consistent with reddening.
We demonstrate that a recently employed method to determine relative abundances
using UV spectra can be done using UVOT photometry, but we warn that accurate
results require an accurate model of the cause of the variations. The abundance
of UV photometry now available should provide constraints on models that
typically rely on UV spectroscopy for constraining metallicity, density, and
other parameters. Nevertheless, UV spectroscopy for a variety of SN explosions
is still needed to guide the creation of accurate models. A better
understanding of the influences affecting the UV is important for using SNe Ia
as cosmological probes, as the UV light may test whether SNe Ia are
significantly affected by evolutionary effects.Comment: 10 pages. Submitted to Ap
Detailed Spectral Modeling of a 3-D Pulsating Reverse Detonation Model: Too Much Nickel
We calculate detailed NLTE synthetic spectra of a Pulsating Reverse
Detonation (PRD) model, a novel explosion mechanism for Type Ia supernovae.
While the hydro models are calculated in 3-D, the spectra use an angle averaged
hydro model and thus some of the 3-D details are lost, but the overall average
should be a good representation of the average observed spectra. We study the
model at 3 epochs: maximum light, seven days prior to maximum light, and 5 days
after maximum light. At maximum the defining Si II feature is prominent, but
there is also a prominent C II feature, not usually observed in normal SNe Ia
near maximum. We compare to the early spectrum of SN 2006D which did show a
prominent C II feature, but the fit to the observations is not compelling.
Finally we compare to the post-maximum UV+optical spectrum of SN 1992A. With
the broad spectral coverage it is clear that the iron-peak elements on the
outside of the model push too much flux to the red and thus the particular PRD
realizations studied would be intrinsically far redder than observed SNe Ia. We
briefly discuss variations that could improve future PRD models.Comment: 15 pages, 4 figures, submitted to Ap
Analysis of the kinetic mechanism of recombinant human isoprenylcysteine carboxylmethyltransferase (Icmt)
BACKGROUND: Isoprenylcysteine carboxyl methyltransferase (Icmt) is the third of three enzymes that posttranslationally modify proteins that contain C-terminal CaaX motifs. The processing of CaaX proteins through this so-called prenylation pathway via a route initiated by addition of an isoprenoid lipid is required for both membrane targeting and function of the proteins. The involvement of many CaaX proteins such as Ras GTPases in oncogenesis and other aberrant proliferative disorders has led to the targeting of the enzymes involved in their processing for therapeutic development, necessitating a detailed understanding of the mechanisms of the enzymes. RESULTS: In this study, we have investigated the kinetic mechanism of recombinant human Icmt. In the reaction catalyzed by Icmt, S-adenosyl-L-methionine (AdoMet) provides the methyl group that is transferred to the second substrate, the C-terminal isoprenylated cysteine residue of a CaaX protein, thereby generating a C-terminal prenylcysteine methyl ester on the protein. To facilitate the kinetic analysis of Icmt, we synthesized a new small molecule substrate of the enzyme, biotin-S-farnesyl-L-cysteine (BFC). Initial kinetic analysis of Icmt suggested a sequential mechanism for the enzyme that was further analyzed using a dead end competitive inhibitor, S-farnesylthioacetic acid (FTA). Inhibition by FTA was competitive with respect to BFC and uncompetitive with respect to AdoMet, indicating an ordered mechanism with SAM binding first. To investigate the order of product dissociation, product inhibition studies were undertaken with S-adenosyl-L-homocysteine (AdoHcy) and the N-acetyl-S-farnesyl-L-cysteine methylester (AFCME). This analysis indicated that AdoHcy is a competitive inhibitor with respect to AdoMet, while AFCME shows a noncompetitive inhibition with respect to BFC and a mixed-type inhibition with respect to AdoMet. These studies established that AdoHcy is the final product released, and that BFC and AFCME bind to different forms of the enzyme. CONCLUSIONS: These studies establish that catalysis by human Icmt proceeds through an ordered sequential mechanism and provide a kinetic framework for analysis of specific inhibitors of this key enzyme
Whispering Gallery States of Antihydrogen
We study theoretically interference of the long-living quasistationary
quantum states of antihydrogen atoms, localized near a concave material
surface. Such states are an antimatter analog of the whispering gallery states
of neutrons and matter atoms, and similar to the whispering gallery modes of
sound and electro-magnetic waves. Quantum states of antihydrogen are formed by
the combined effect of quantum reflection from van der Waals/Casimir-Polder
(vdW/CP) potential of the surface and the centrifugal potential. We point out a
method for precision studies of quantum reflection of antiatoms from vdW/CP
potential; this method uses interference of the whispering gallery states of
antihydrogen.Comment: 13 pages 7 figure
A new hard-particle model for anisotropic fluids
We report a new hard-particle model system consisting of hard cylinders, we have determined the geometrical conditions that let us know whether or not two given cylinders overlap. In addition we have carried out Monte Carlo simulations sampling the canonical ensemble on this system, the numerical results indicate that this system exhibits mesomorphic behaviour
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