John G. Barnwell to Susan Ursin Niemcewicz, March 3, 1815

John G. Barnwell wrote from Beaufort, SC to Susan Ursin Niemcewicz, addressed to Elizabethtown, NJ. Susan had written to him previously to express sympathy for the loss of his uncle. He states that he would like to pay off his uncle\u27s bond and asks how Susan would like to receive the funds. People Included: Robert Barnwellhttps://digitalcommons.kean.edu/lhc_1810s/1012/thumbnail.jp

Plasmodium vivax: who cares?

More attention is being focused on malaria today than any time since the world's last efforts to achieve eradication over 40 years ago. The global community is now discussing strategies aimed at dramatically reducing malarial disease burden and the eventual eradication of all types of malaria, everywhere. As a consequence, Plasmodium vivax, which has long been neglected and mistakenly considered inconsequential, is now entering into the strategic debates taking place on malaria epidemiology and control, drug resistance, pathogenesis and vaccines. Thus, contrary to the past, the malaria research community is becoming more aware and concerned about the widespread spectrum of illness and death caused by up to a couple of hundred million cases of vivax malaria each year. This review brings these issues to light and provides an overview of P. vivax vaccine development, then and now. Progress had been slow, given inherent research challenges and minimal support in the past, but prospects are looking better for making headway in the next few years. P. vivax, known to invade the youngest red blood cells, the reticulocytes, presents a strong challenge towards developing a reliable long-term culture system to facilitate needed research. The P. vivax genome was published recently, and vivax researchers now need to coordinate efforts to discover new vaccine candidates, establish new vaccine approaches, capitalize on non-human primate models for testing, and investigate the unique biological features of P. vivax, including the elusive P. vivax hypnozoites. Comparative studies on both P. falciparum and P. vivax in many areas of research will be essential to eradicate malaria. And to this end, the education and training of future generations of dedicated "malariologists" to advance our knowledge, understanding and the development of new interventions against each of the malaria species infecting humans also will be essential

Utility of immunohistochemical markers in differentiating benign from malignant follicular-derived thyroid nodules

<p>Abstract</p> <p>Background</p> <p>Thyroid nodules are common among adults though only a small percentage is malignant, which can histologically mimic benign nodules. Accurate diagnosis of these thyroid nodules is critical for the proper clinical management.</p> <p>Methods</p> <p>We investigated immunoexpression in 98 surgically removed benign thyroid nodules including 52 hyperplastic nodules (HN) and 46 follicular/Hurthle cell adenomas (FA), and 54 malignant tumors including 22 follicular carcinoma (FC), 20 classic papillary carcinoma (PTC), and 12 follicular variant papillary carcinoma (FVPC).</p> <p>Results</p> <p>The staining results showed that malignant tumors express galectin-3, HBME-1, CK19 and Ret oncoprotein significantly more than benign nodules. The sensitivity of these markers for the distinction between benign and malignant lesions ranged from 83.3% to 87%. The sensitivity of two-marker panels was not significantly different. Immunoexpression was usually diffuse and strong in malignant tumors, and focal and weak in the benign lesions.</p> <p>Conclusion</p> <p>Our findings indicate that these immunomarkers are significantly more expressed in malignant tumors compared to benign lesions and may be of additional diagnostic value when combined with routine histology.</p

The circulatory effects produced in a patient with pneumopericardium by artificially varying the intrapericardial pressure

1. 1. Observations on changes in pulse rate, respiratory rate, arterial pressure, venous pressure, and circulation time were made with artificially produced changes in intrapericardial pressure in a patient with pneumopericardium. These relationships have been illustrated graphically.2. 2. The intrapericardial pressure fluctuated with respiration, and, as higher pressures were reached, these fluctuations decreased.3. 3. The intrapericardial pressure fluctuated with systole and diastole. Kymographic tracings were made of the fluctuations in intrapericardial pressure caused by respiration and the heartbeat. With the higher intrapericardial pressures, the changes in pressure produced by systole and diastole were less marked.4. 4. Significant changes in pulse rate, arterial pressure, venous pressure, and circulation time did not occur until the intrapericardial pressure was elevated to, or above, 145 mm. of water.5. 5. In order to maintain the circulation, it was necessary that venous pressure exceed intrapericardial pressure by at least 35 to 40 mm. of water.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/32599/1/0000739.pd

Preliminary Results from the CHOMPTT Laser Time-Transfer Mission

CubeSat Handling of Multisystem Precision Time Transfer (CHOMPTT) is a demonstration of precision ground-to-space time-transfer using a laser link to an orbiting CubeSat. The University of Florida-led mission is a collaboration with the NASA Ames Research Center. The 1U optical time-transfer payload was designed and built by the Precision Space Systems Lab at the University of Florida. The payload was integrated with a NASA Ames NOdeS-derived spacecraft bus to form a 3U spacecraft. The CHOMPTT satellite was successfully launched into low Earth orbit on 16 December 2018 on NASA’s ELaNa XIX mission using the Rocket Lab USA Electron vehicle. Here we describe the mission and report on the status of this unique technology demonstration. We use two satellite laser ranging facilities located at the Kennedy Space Center and Mount Stromlo, Australia to transmit nanosecond, 1064 nm laser pulses to the CHOMPTT CubeSat. These pulses are timed with an atomic clock on the ground and are detected by an avalanche photodetector on CHOMPTT. An event timer records the arrival time with respect to one of the two on-board chip-scale atomic clocks with an accuracy of 200 ps (6cm light-travel time). At the same time, a retroreflector returns the transmitted beam back to the ground. By comparing the transmitted and received times on the ground and the arrival time of the pulses at the CubeSat, the time difference between the ground and space clocks can be measured. This compact, power efficient and secure synchronization technology will enable advanced space navigation, communications, networking, and distributed aperture telescopes in the future

The Role of Animal Models for Research on Severe Malaria

In light of the recent controversies over the role of animal models for research into the development of new treatments for severe malaria, particularly cerebral disease, a group of scientists came together to discuss the relative merits of a range of animal models and their overlap with the complex clinical syndromes of human disease. While it was not possible to fully resolve differences over the utility of the Plasmodium berghei ANKA model of experimental cerebral malaria, the meeting did bring the two research communities closer together to identify further work to provide information needed to validate the model and revitalise the development of other animal models displaying features of human pathology. The driving force behind this was the desire to ensure better translation of experimental findings into effective treatments for severe malaria

An assessment of false positive rates for malaria rapid diagnostic tests caused by non-Plasmodium infectious agents and immunological factors.

BACKGROUND: Malaria rapid diagnostic tests (RDTs) can produce false positive (FP) results in patients with human African trypanosomiasis and rheumatoid factor (RF), but specificity against other infectious agents and immunological factors is largely unknown. Low diagnostic specificity caused by cross-reactivity may lead to over-estimates of the number of malaria cases and over-use of antimalarial drugs, at the cost of not diagnosing and treating the true underlying condition. METHODS: Data from the WHO Malaria RDT Product Testing Programme was analysed to assess FP rates of 221 RDTs against four infectious agents (Chagas, dengue, Leishmaniasis and Schistosomiasis) and four immunological factors (anti-nuclear antibody, human anti-mouse antibody (HAMA), RF and rapid plasma regain). Only RDTs with a FP rate against clean negative samples less than 10% were included. Paired t-tests were used to compare product-specific FP rates on clean negative samples and samples containing non-Plasmodium infectious agents and immunological factors. RESULTS: Forty (18%) RDTs showed no FP results against any tested infectious agent or immunological factor. In the remaining RDTs significant and clinically relevant increases in FP rates were observed for samples containing HAMA and RF (P<0.001). There were significant correlations between product-matched FP rates for RF and HAMA on all RDT test bands (P<0.001), and FP rates for each infectious agent and immunological factor were also correlated between test bands of combination RDTs (P≤0.002). CONCLUSIONS: False positive results against non-Plasmodium infectious agents and immunological factors does not appear to be a universal property of malaria RDTs. However, since many malaria RDTs have elevated FP rates against HAMA and RF positive samples practitioners may need to consider the possibility of false positive results for malaria in patients with conditions that stimulate HAMA or RF