The transcription factor BATF operates as an essential differentiation checkpoint in early effector CD8+ T cells

The transcription factor BATF is required for interleukin 17 (IL-17)-producing helper T cell (TH17) and follicular helper T cell (TFH) differentiation. Here, we show that BATF also has a fundamental role in regulating effector CD8+ T cell differentiation. BATF-deficient CD8+ T cells show profound defects in effector expansion and undergo proliferative and metabolic catastrophe early after antigen encounter. BATF, together with IRF4 and Jun proteins, binds to and promotes early expression of genes encoding lineage-specific transcription-factors (T-bet and Blimp-1) and cytokine receptors, while paradoxically repressing genes encoding effector molecules (IFN-γ and granzyme B). Thus, BATF amplifies TCR-dependent transcription factor expression and augments inflammatory signal propagation but restrains effector gene expression. This checkpoint prevents irreversible commitment to an effector fate until a critical threshold of downstream transcriptional activity has been achieved

Bloom-p-field, Chom-p-sky, and Phonetic Epen-t-thesis

published or submitted for publicationis peer reviewe

Reading comprehension of pronoun-referent structures by children in grades two, four, and six

Based on the author's doctoral dissertation, University of Illinois.The research reported herein was supported in part by the National Institute of Educatio

Interrelationship of orthography and phonological structure in learning to read

Bibliography: p. 45-5

Story structure and age effects on children's ability to sequence stories

The research reported herein was supported in part by the National Institute of Education.The research reported herein was supported in part by the National Institute of Educatio