Evaluating air traffic flow management in a collaborative decision-making environment

The collaborative decision-making (CDM) framework introduced into ground delay programs in the late 1990s is an integral component of FAA's traffic flow management (TFM) procedures. CDM allows FAA to act as a mediator when managing TFM programs, transferring as much decision making as possible to the individual airlines. Although this approach has been highly successful in practice, it creates a new question for the research community: How should proposed enhancements to TFM be evaluated in a CDM environment? A sequential evaluation procedure, developed in this paper, addresses this question. The procedure includes airline disruption responses and a quasi-compression operation, attempting to mimic the three-stage CDM process. To model airline disruption responses, an integer optimization model was developed to balance operational and passenger considerations in determining which flights to cancel, swap, or delay. The value of this procedure is demonstrated by analyzing an optimization-based TFM approach in the CDM environment

Valuing Immature Grain Crops as Forage

Late planted corn, soybeans and oats crops can be harvested as forages instead of for grain. Options include corn or oat silage, earlage, and oat or soybean hay. Estimating a value for these crops is made difficult by the fact there are few reported prices or significant markets in which they are bought and sold. However, there are two other general approaches to valuing grain crops harvested as forage. Both are based on comparisons to alternative actions by either the forage buyer or seller

Foundations in Wisconsin: A Directory [32nd ed. 2013]

The 2013 edition of Foundations in Wisconsin marks the 32nd production of the print directory and the 13th year of the online version. The directory is designed as a research tool for grantseekers interested in locating information on private, corporate, and community foundations registered in Wisconsin. Each entry in this new edition has been updated or reviewed to provide the most current information available. Most of the data was drawn from IRS 990-PF tax returns filed by the foundations. Additional information was obtained from surveys, foundation websites, annual reports, and newsletters.https://epublications.marquette.edu/lib_fiw/1011/thumbnail.jp

Mild recessive epidermolytic hyperkeratosis associated with a novel keratin 10 donor splice-site mutation in a family of Norfolk terrier dogs

Background  Epidermolytic hyperkeratosis in humans is caused by dominant-negative mutations in suprabasal epidermal keratins 1 and 10. However, spontaneous keratin mutations have not been confirmed in a species other than human. Objectives  To describe an autosomal recessive, mild, nonpalmar/plantar epidermolytic ichthyosis segregating in an extended pedigree of Norfolk terrier dogs due to a splice-site mutation in the gene encoding keratin 10 (KRT10). Methods  Dogs were evaluated clinically, and skin samples were examined by light and electron microscopy. Genomic DNA samples and cDNA from skin RNA were sequenced and defined a mutation in KRT10. Consequences of the mutation were evaluated by assessing protein expression with immunohistochemistry and Western blotting and gene expression with real-time RT-PCR (reverse transcriptase-polymerase chain reaction). Results  Adult dogs with the disease had generalized, pigmented hyperkeratosis with epidermal fragility. Light microscopic examination defined epidermolysis with hyperkeratosis; ultrastructural changes included a decrease in tonofilaments and abnormal filament aggregation in upper spinous and granular layer keratinocytes. Affected dogs were homozygous for a single base GT→TT change in the consensus donor splice site of intron 5 in KRT10. Keratin 10 protein was not detected with immunoblotting in affected dogs. Heterozygous dogs were normal based on clinical and histological appearance and keratin 10 protein expression. The mutation caused activation of at least three cryptic or alternative splice sites. Use of the cryptic sites resulted in transcripts containing premature termination codons. One transcript could result in shortening of the proximal portion of the 2B domain before the stutter region. Quantitative real-time PCR indicated a significant decrease in KRT10 mRNA levels in affected dogs compared with wild-type dogs. Conclusions  This disease is the first confirmed spontaneous keratin mutation in a nonhuman species and is the first reported recessive form of epidermolytic hyperkeratosis.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/74670/1/j.1365-2133.2005.06735.x.pd

Transgenic Maize Hybrid Crop Residues: Nutritive Value and Their Effects on Performance of Grazing Beef Cows

Several maize (Zea mays) hybrids, including three transgenic hybrids containing Bacillus thuringiensis (Bt) enzymes (Bt-maize hybrids), were planted in a field study. Mature, midgestation, beef cows (Bos tarus) strip-grazed post-harvest residues as paddocks over 126 days. Body condition-scores and weights were monitored. Forage yield, weathering losses and forage composition were monitored on grazed and ungrazed areas. Forage selection and intake were estimated. Grain yields, dropped grain, initial crop residue concentrations of dry matter (DM), organic matter (OM) and in vitro digestible organic matter (IVDOM) yields were similar among hybrids. Hybrids varied in infestation of maize borers, initial amounts of residue DM, acid detergent fiber (ADF) and acid detergent lignin (ADL) and IVDOM. Mean rates of change in forage and concentration of IVDOM selected by steers was similar between hybrids. Cows grazing residues required 50% less supplemental hay to retain the same body condition as cows consuming hay in drylot

Reinforcement Learning for Variable Selection in a Branch and Bound Algorithm

Mixed integer linear programs are commonly solved by Branch and Bound algorithms. A key factor of the efficiency of the most successful commercial solvers is their fine-tuned heuristics. In this paper, we leverage patterns in real-world instances to learn from scratch a new branching strategy optimised for a given problem and compare it with a commercial solver. We propose FMSTS, a novel Reinforcement Learning approach specifically designed for this task. The strength of our method lies in the consistency between a local value function and a global metric of interest. In addition, we provide insights for adapting known RL techniques to the Branch and Bound setting, and present a new neural network architecture inspired from the literature. To our knowledge, it is the first time Reinforcement Learning has been used to fully optimise the branching strategy. Computational experiments show that our method is appropriate and able to generalise well to new instances

Clinical indicators for success of misoprostol treatment after early pregnancy failure

Objective To identify clinical indicators for success of misoprostol treatment after early pregnancy failure. Methods A total of 473 women with early pregnancy failure received 800 μg of vaginal misoprostol on treatment day 1. At the follow-up visit on day 3, a second dose was given if expulsion was incomplete. On day 8, vacuum aspiration was offered if expulsion had not occurred. Ultrasonography was used as gold standard for success. A Classification and Regression Tree analysis was undertaken to derive two decision trees for the success of misoprostol treatment on study days 3 and 8. Results Heavy bleeding after the first dose and an open cervical os were identified as clinical indicators of treatment success on day 3. Treatment success occurred in 84% of women with either or both indicators. Reporting passage of tissue after a second misoprostol dose and old blood in the vagina were potential indicators of treatment success or failure on day 8. A woman with either of these indicators has a 65% chance of treatment success after the second dose. Conversely, a woman with neither indicator on day 8 has a 94% chance of treatment failure. Conclusion Standard clinical findings may be useful as indicators for success or failure of medical management of early pregnancy failure in settings with limited or no access to ultrasonography. More research to identify even better indicators is warranted

Foundations in Wisconsin: A Directory [33rd ed. 2014]

The 2014 release of Foundations in Wisconsin marks the 33rd edition of the print directory and the 14th year of the online version. The directory is designed as a research tool for grantseekers interested in locating information on private, corporate, and community foundations registered in Wisconsin. Each entry in this new edition has been updated or reviewed to provide the most current information available. Most of the data was drawn from IRS 990-PF tax returns filed by the foundations. Additional information was obtained from surveys, foundation websites, annual reports, and newsletters.https://epublications.marquette.edu/lib_fiw/1012/thumbnail.jp

Strip intercropping systems

Economic, environmental, and biological concerns prompt the search for alternative, sustainable, agricultural production systems. Farmers need cropping systems that reduce negative impacts on the environment while maintaining or even improving farm profitabilit