Family Violence Across the Lifespan: An Introduction

Streamlined and updated throughout with state-of-the-art information, this Third Edition of the authors′ bestselling book gives readers an accessible introduction to the methodology, etiology, prevalence, treatment, and prevention of family violence. Research from experts in the fields of psychology, sociology, criminology, and social welfare informs the book′s broad coverage of current viewpoints and debates within the field. Organized chronologically, chapters cover child physical, sexual, and emotional abuse; abused and abusive adolescents; courtship violence and date rape; spouse abuse, battered women, and batterers; and elder abuse.https://digitalcommons.pepperdine.edu/facultybooks/1033/thumbnail.jp

Pro-Poor Price Trends and Inequality -- The Case of India

It is well known that people's consumption patterns change with income. Relative price changes therefore affect rich and poor consumers differently. Yet, the standard price indices are not income-specific and hence, the use of these mask these differences in cost-of-living. In this paper, we study consumption inequality in India, while fully allowing for non-homotheticity. Our analysis shows that the changes in relative prices in a large part of the period from 1993 to 2012 were pro-poor, in the sense that they favored the poor relative to the rich. As a result, we also find that the standard measures significantly overestimate the rise in real inequality. Moreover, we show that the allowance for non-homotheticity is quantitatively much more important in our application than the adjustment for substitution in consumption, despite the larger attention paid to the latter in the literature. We also illustrate how conventional measures exaggerate inter-temporal changes in inequality when there is segregation in consumption/production, by which we mean that people's consumption patterns are skewed towards goods intensively produced by people of their own group

A SNP in the HTT promoter alters NF-κB binding and is a bidirectional genetic modifier of Huntington disease

Cis-regulatory variants that alter gene expression can modify disease expressivity, but none have previously been identified in Huntington disease (HD). Here we provide in vivo evidence in HD patients that cis-regulatory variants in the HTT promoter are bidirectional modifiers of HD age of onset. HTT promoter analysis identified a NF-κB binding site that regulates HTT promoter transcriptional activity. A non-coding SNP, rs13102260:G > A, in this binding site impaired NF-κB binding and reduced HTT transcriptional activity and HTT protein expression. The presence of the rs13102260 minor (A) variant on the HD disease allele was associated with delayed age of onset in familial cases, whereas the presence of the rs13102260 (A) variant on the wild-type HTT allele was associated with earlier age of onset in HD patients in an extreme case-based cohort. Our findings suggest a previously unknown mechanism linking allele-specific effects of rs13102260 on HTT expression to HD age of onset and have implications for HTT silencing treatments that are currently in development