Physiological responses to prolonged bed rest in humans: A compendium of research, 1981-1988

Clinical observations and results form more basic studies that help to elucidate the physiological mechanisms of the adaptation of humans to prolonged bed rest. If the authors' abstract or summary was appropriate, it was included. In some cases a more detailed synopsis was provided under the subheadings of purpose, methods, results, and conclusions

Activation mechanisms in sodium-doped Silicon MOSFETs

We have studied the temperature dependence of the conductivity of a silicon MOSFET containing sodium ions in the oxide above 20 K. We find the impurity band resulting from the presence of charges at the silicon-oxide interface is split into a lower and an upper band. We have observed activation of electrons from the upper band to the conduction band edge as well as from the lower to the upper band. A possible explanation implying the presence of Hubbard bands is given.Comment: published in J. Phys. : Condens. Matte

The Radial Orbit Instability in Collisionless N-Body Simulations

Using a suite of self-gravitating, collisionless N-body models, we systematically explore a parameter space relevant to the onset and behavior of the radial orbit instability (ROI), whose strength is measured by the systemic axis ratios of the models. We show that a combination of two initial conditions, namely the velocity anisotropy and the virial ratio, determines whether a system will undergo ROI and exactly how triaxial the system will become. A third initial condition, the radial shape of the density profile, plays a smaller, but noticeable role. Regarding the dynamical development of the ROI, the instability a) begins after systems collapse to their most compact configuration and b) evolves fastest when a majority of the particles have radially anisotropic orbits while there is a lack of centrally-concentrated isotropic orbits. We argue that this is further evidence that self-reinforcing torques are the key to the onset of the ROI. Our findings support the idea that a separate orbit instability plays a role in halting the ROI.Comment: accepted for publication in ApJ. 9 figures in emulateapj styl

Constraints on Solar Wind Acceleration Mechanisms from Ulysses Plasma Observations: The First Polar Pass

The mass flux density and velocity of the solar wind at polar latitudes can provide strong constraints on solar wind acceleration mechanisms. We use plasma observations from the first polar passage of the Ulysses spacecraft to investigate this question. We find that the mass flux density and velocity are too high to reconcile with acceleration of the solar wind by classical thermal conduction alone. Therefore acceleration of the high-speed must involve extended deposition of energy by some other mechanism, either as heat or as a direct effective pressure, due possibly to waves and/or turbulence, or completely non-classical heat transport

Comprehensive School Guidance Programs in Nebraska: Implications for Rural Schools

Archival data from an in-state survey of 428 elementary and secondary school counselors completed by the Nebraska Department of Education regarding comprehensive guidance programs was reviewed for relevant information. This information is discussed relative to the current views and knowledge regarding the state of comprehensive developmental guidance and their implications for school counselors and administrators

Distinguishing Among Strong Decay Models

Two competing models for strong hadronic decays, the $^3P_0$ and $^3S_1$ models, are currently in use. Attempts to rule out one or the other have been hindered by a poor understanding of final state interactions and by ambiguities in the treatment of relativistic effects. In this article we study meson decays in both models, focussing on certain amplitude ratios for which the relativistic uncertainties largely cancel out (notably the $S/D$ ratios in $b_1\rightarrow\pi\omega$ and $a_1\rightarrow\pi\rho$), and using a Quark Born Formalism to estimate the final state interactions. We find that the $^3P_0$ model is strongly favoured. In addition, we predict a $P/F$ amplitude ratio of $1.6\pm .2$ for the decay $\pi_2\rightarrow\pi\rho$. We also study the parameter-dependence of some individual amplitudes (as opposed to amplitude ratios), in an attempt to identify a ``best'' version of the $^3P_0$ model.Comment: 20 pages, uuencoded postscript file with 7 figures, MIT-CTP-2295; CMU-HEP94-1

The Lick-Carnegie Survey: Four New Exoplanet Candidates

We present new precise HIRES radial velocity (RV) data sets of five nearby stars obtained at Keck Observatory. HD 31253, HD 218566, HD 177830, HD 99492 and HD 74156 are host stars of spectral classes F through K and show radial velocity variations consistent with new or additional planetary companions in Keplerian motion. The orbital parameters of the candidate planets in the five planetary systems span minimum masses of M sin i = 27.43 M_{earth} to M sin i = 8.28 M_{jup}, periods of 17.05 to 4696.95 days and eccentricities ranging from circular to extremely eccentric (e ~ 0.63). The 5th star, HD 74156, was known to have both a 52-day and a 2500-day planet, and was claimed to also harbor a 3rd planet at 336d, in apparent support of the "Packed Planetary System" hypothesis. Our greatly expanded data set for HD 74156 provides strong confirmation of both the 52-day and 2500-d planets, but strongly contradicts the existence of a 336-day planet, and offers no significant evidence for any other planets in the system.Comment: 13 pages, 15 figures. Accepted for publication in ApJ. Fixed typos in Table 2. Additional material at http://www.ucolick.org/~smeschia/4planet.ph

Combinations of isoform-targeted histone deacetylase inhibitors and bryostatin analogues display remarkable potency to activate latent HIV without global T-cell activation

AbstractCurrent antiretroviral therapy (ART) for HIV/AIDS slows disease progression by reducing viral loads and increasing CD4 counts. Yet ART is not curative due to the persistence of CD4+ T-cell proviral reservoirs that chronically resupply active virus. Elimination of these reservoirs through the administration of synergistic combinations of latency reversing agents (LRAs), such as histone deacetylase (HDAC) inhibitors and protein kinase C (PKC) modulators, provides a promising strategy to reduce if not eradicate the viral reservoir. Here, we demonstrate that largazole and its analogues are isoform-targeted histone deacetylase inhibitors and potent LRAs. Significantly, these isoform-targeted HDAC inhibitors synergize with PKC modulators, namely bryostatin-1 analogues (bryologs). Implementation of this unprecedented LRA combination induces HIV-1 reactivation to unparalleled levels and avoids global T-cell activation within resting CD4+ T-cells.</jats:p