9 research outputs found
Mosquito cellular immunity at single-cell resolution
Get PDFHemocytes limit the capacity of mosquitoes to transmit human pathogens. Here we profile the transcriptomes of 8506 hemocytes of Anopheles gambiae and Aedes aegypti mosquito vectors. This revealed functional diversity of hemocytes, with different subtypes of granulocytes expressing distinct and evolutionarily conserved subsets of effector genes. A new cell type in A. gambiae, which we term megacyte, is defined by a unique transmembrane protein marker (TM7318) and high expression of LPS-Induced TNF-alpha transcription factor 3 (LL3). Knock-down experiments indicate that LL3 mediates hemocyte differentiation during immune priming. We identify and validate two main hemocyte lineages and find evidence of proliferating granulocyte populations. This atlas of medically relevant invertebrate immune cells at single cell resolution identifies cellular events that underpin mosquito immunity to malaria infection
Differences in genome characters and cell tropisms between two chikungunya isolates of Asian lineage and Indian Ocean lineage
No full textEntomopathogenic fungal infection leads to temporospatial modulation of the mosquito immune system
No full textThe consequences of Brugia malayi infection on the flight and energy resources of Aedes aegypti mosquitoes
No full textHeme Signaling Impacts Global Gene Expression, Immunity and Dengue Virus Infectivity in Aedes aegypti
No full textA Lipidomics Approach in the Characterization of Zika-Infected Mosquito Cells: Potential Targets for Breaking the Transmission Cycle
No full textCatalase protects Aedes aegypti from oxidative stress and increases midgut infection prevalence of Dengue but not Zika
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