Characterization of nanofluids formed by fumed Al2O3 in water for geothermal applications

The European Project Cheap-GSHPs, recently approved, aims at reducing the total cost of shallow geothermal systems by 20-30%, also improving actual drilling/installation technologies and designs of Ground Source Heat Exchangers (GSHEs), in combination with a holistic engineering approach to optimize the entire systems for building and district heating and cooling applications, across the different underground and climate conditions existing within the EU. In this frame, the efficiency of the system heat pump/GSHE will be an important task and a part of this project will be on the analyses of possible alternative secondary fluids to be used in the geothermal probe. Here, suspensions of fumed Al2O3 in water will be considered as possible efficient secondary fluids. Three different concentrations will be studied, i.e. 10%, 30% and 40%, and the stability, thermal conductivity and dynamic viscosity of these fluids will be characterized, in order to analyse their possible employment as thermal fluids

A high definition picture of somatic mutations in chronic lymphoproliferative disorder of natural killer cells

The molecular pathogenesis of chronic lymphoproliferative disorder of natural killer (NK) cells (CLPD-NK) is poorly understood. Following the screening of 57 CLPD-NK patients, only five presented STAT3 mutations. WES profiling of 13 cases negative for STAT3/STAT5B mutations uncovered an average of 18 clonal, population rare and deleterious somatic variants per patient. The mutational landscape of CLPD-NK showed that most patients carry a heavy mutational burden, with major and subclonal deleterious mutations co-existing in the leukemic clone. Somatic mutations hit genes wired to cancer proliferation, survival, and migration pathways, in the first place Ras/MAPK, PI3K-AKT, in addition to JAK/STAT (PIK3R1 and PTK2). We confirmed variants with putative driver role of MAP10, MPZL1, RPS6KA1, SETD1B, TAOK2, TMEM127, and TNFRSF1A genes, and of genes linked to viral infections (DDX3X and RSF1) and DNA repair (PAXIP1). A truncating mutation of the epigenetic regulator TET2 and a variant likely abrogating PIK3R1-negative regulatory activity were validated. This study significantly furthered the view of the genes and pathways involved in CLPD-NK, indicated similarities with aggressive diseases of NK cells and detected mutated genes targetable by approved drugs, being a step forward to personalized precision medicine for CLPD-NK patients.Peer reviewe