The Role of Sauropus androgynous (L.) Merr. Leaf Powder in the Broiler Chickens Fed a Diet Naturally Contaminated with Aflatoxin

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PENGARUH AFLATOKSIN PADA PAKAN TERHADAP RESIDU AFLATOKSIN DAN HISTOPATOLOGI ORGAN KULIT, BURSA FABRISIUS PADA AYAM BROILER UMUR 7, 14, DAN 21 HARI

Aflatoksin adalah mikotoksin yang diproduksi oleh Aspergillus. Aflatoksin mengganggu pertumbuhan dan imunosupresi pada hewan. Tujuan penelitian ini untuk mengetahui efek aflatoksin pada kulit dan bursa Fabricius pada ayam broiler. Enam puluh ayam broiler digunakan dalam penelitian ini dan dibagi menjadi empat kelompok berdasarkan pemberian kontaminasi aflatoksin untuk kelompok I 0 ppb (kontrol), kelompok II aflatoksin ≤50 ppb, kelompok III 50ppb 0,05). The bursa Fabricius dalam kelompok IV menunjukkan penipisan limfoid, kemacetan, dan peradangan dan itu berbeda dengan yang lain (p <0,05). Namun, tidak ditemukan perubahan histopatologis pada kulit ayam pedaging. Studi ini membuktikan bahwa aflatoksin mempengaruhi residu dan histopatologi bursa Fabricius

The Role of Sauropus androgynus (L.) Merr. Leaf Powder in the Broiler Chickens Fed a Diet Naturally Contaminated with Aflatoxin

Aflatoxin (AF) is the secondary metabolite of Aspergillus flavus and commonly contaminates feed during storage. AF causes lowered growth rate, stress, and increased mortality in the poultry, especially for broiler industries. The aims of this study are to determine the effects of Sauropus androgynus (L.) Merr. leaf powder (SAP) in the chickens fed a diet naturally contaminated with AF. A total of 108 chickens are divided into 6 group: group I fed with basal diet (AF not detectable); group II fed with basal diet (AF not detectable) + 5% SAP; group III with AF (>1 ppb 1 ppb 51 ppb 101 ppb <150 ppb) + 5% SAP. The data of the body weight, feed intake and efficiency, the relative weight of liver, kidney, spleen, bursa of Fabricius (BF), histopathology, haematological profile, haemagglutination inhibition (HI) titer, AF residue, and immunohistochemistry are collected on days 7, 14, and 21. All the data were analysed using SPSS 16. The supplementation of 5% SAP in the chickens fed a diet naturally contaminated with AF showed the potential effects of the body weight performance, haematological profile protection, increase in the cellular and humoral immune responses, reduction of AF residue in the organ, protection of liver, kidney, spleen, and BF histopathology, and increase in the immune-expression of CD4+/CD8+ lymphocytes ratio (P < 0.05). It shows that 5% SAP can be used as the alternative herbal supplementation to depress the impacts of aflatoxicosis in the broiler chickens