125 research outputs found
Indução de mutação em genótipos de arroz submetidos a estresse por baixas temperaturas no estádio germinativo.
CIC UFPelotas
Linhagens de arroz irrigado da Embrapa Clima Temperado frente à toxidez por herbicida do grupo químico das imidazolinonas.
Este trabalho teve como objetivo avaliar cruzamentos entre plantas de arroz irrigado tolerantes e sensíveis a herbicidas do grupo químico das imidazolinas, através da avaliação de linhagens em geração F2
Minhocas em sistemas de uso do solo: estudo de caso em Assistência, SP.
Resumo. 5° ELAETAO
Indicadores de qualidade do solo em sistemas de uso do solo: estudo de caso em Assistência, SP.
Resumo. 5° ELAETAO
Hematopoietic Cell Transplantation Cures Adenosine Deaminase 2 Deficiency: Report on 30 Patients.
Deficiency of adenosine deaminase 2 (DADA2) is an inherited inborn error of immunity, characterized by autoinflammation (recurrent fever), vasculopathy (livedo racemosa, polyarteritis nodosa, lacunar ischemic strokes, and intracranial hemorrhages), immunodeficiency, lymphoproliferation, immune cytopenias, and bone marrow failure (BMF). Tumor necrosis factor (TNF-α) blockade is the treatment of choice for the vasculopathy, but often fails to reverse refractory cytopenia. We aimed to study the outcome of hematopoietic cell transplantation (HCT) in patients with DADA2.
We conducted a retrospective study on the outcome of HCT in patients with DADA2. The primary outcome was overall survival (OS).
Thirty DADA2 patients from 12 countries received a total of 38 HCTs. The indications for HCT were BMF, immune cytopenia, malignancy, or immunodeficiency. Median age at HCT was 9 years (range: 2-28 years). The conditioning regimens for the final transplants were myeloablative (n = 20), reduced intensity (n = 8), or non-myeloablative (n = 2). Donors were HLA-matched related (n = 4), HLA-matched unrelated (n = 16), HLA-haploidentical (n = 2), or HLA-mismatched unrelated (n = 8). After a median follow-up of 2 years (range: 0.5-16 years), 2-year OS was 97%, and 2-year GvHD-free relapse-free survival was 73%. The hematological and immunological phenotypes resolved, and there were no new vascular events. Plasma ADA2 enzyme activity normalized in 16/17 patients tested. Six patients required more than one HCT.
HCT was an effective treatment for DADA2, successfully reversing the refractory cytopenia, as well as the vasculopathy and immunodeficiency.
HCT is a definitive cure for DADA2 with > 95% survival
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