Schaulaufen der amerikanischen Narratologie: Grundkonzepte der Erzähltheorie im direkten Vergleich

David Herman, James Phelan, Peter J. Rabinowitz, Brian Richardson, Robyn Warhol: Narrative Theory. Core Concepts and Critical Debate. Columbus: The Ohio State University Press 2012 (= Theory and Interpretation of Narrative, ohne Nummer). 282 + XIV S. EUR 31,99 (Taschenbuch). ISBN 978-0-8142-5184-3 Wenn es so etwas wie eine offene amerikanische Meisterschaft der Narratologie gäbe, dann wäre die Gemeinschaftsproduktion von David Herman, James Phelan, Peter Rabinowitz, Brian Richardson und Robyn Warhol das Schaulaufen der Medaillenträger – auch wenn Pflicht und Kür ebenfalls ihren Platz in dieser beeindruckenden Publikation haben

Assessing Lymphatic Route of CSF Outflow and Peripheral Lymphatic Contractile Activity During Head-Down Tilt Using Near-Infrared Fluorescence Imaging

Evidence overwhelmingly suggests that the lymphatics play a critical role in the clearance of cerebrospinal fluid (CSF) from the cranial space. Impairment of CSF outflow into the lymphatics is associated with a number of pathological conditions including spaceflight-associated neuro-ocular syndrome (SANS), a problem that limits long-duration spaceflight. We used near-infrared fluorescence lymphatic imaging (NIRFLI) to dynamically visualize the deep lymphatic drainage pathways shared by CSF outflow and disrupted during head-down tilt (HDT), a method used to mimic the cephalad fluid shift that occurs in microgravity. After validating CSF clearance into the lymph nodes of the neck in swine, a pilot study was conducted in human volunteers to evaluate the effect of gravity on the flow of lymph through these deep cervical lymphatics. Injected into the palatine tonsils, ICG was imaged draining into deep jugular lymphatic vessels and subsequent cervical lymph nodes. NIRFLI was performed under HDT, sitting, and supine positions. NIRFLI shows that lymphatic drainage through pathways shared by CSF outflow are dependent upon gravity and are impaired under short-term HDT. In addition, lymphatic contractile rates were evaluated from NIRFLI following intradermal ICG injections of the lower extremities. Lymphatic contractile activity in the legs was slowed in the gravity neutral, supine position, but increased under the influence of gravity regardless of whether its force direction opposed (sitting) or favored (HDT) lymphatic flow toward the heart. These studies evidence the role of a lymphatic contribution in SANS