The mechanisms of movement control and time estimation in cervical dystonia patients

Traditionally, the pathophysiology of cervical dystonia has been regarded mainly in relation to neurochemical abnormities in the basal ganglia. Recently, however, substantial evidence has emerged for cerebellar involvement. While the absence of neurological "cerebellar signs" in most dystonia patients may be considered at least provoking, there are more subtle indications of cerebellar dysfunction in complex, demanding tasks. Specifically, given the role of the cerebellum in the neural representation of time, in the millisecond range, dysfunction to this structure is considered to be of greater importance than dysfunction of the basal ganglia. In the current study, we investigated the performance of cervical dystonia patients on a computer task known to engage the cerebellum, namely, the interception of a moving target with changing parameters (speed, acceleration, and angle) with a simple response (pushing a button). The cervical dystonia patients achieved significantly worse results than a sample of healthy controls. Our results suggest that the cervical dystonia patients are impaired at integrating incoming visual information with motor responses during the prediction of upcoming actions, an impairment we interpret as evidence of cerebellar dysfunction

The mystery of the cerebellum: clues from experimental and clinical observations

Abstract The cerebellum has a striking homogeneous cytoarchitecture and participates in both motor and non-motor domains. Indeed, a wealth of evidence from neuroanatomical, electrophysiological, neuroimaging and clinical studies has substantially modified our traditional view on the cerebellum as a sole calibrator of sensorimotor functions. Despite the major advances of the last four decades of cerebellar research, outstanding questions remain regarding the mechanisms and functions of the cerebellar circuitry. We discuss major clues from both experimental and clinical studies, with a focus on rodent models in fear behaviour, on the role of the cerebellum in motor control, on cerebellar contributions to timing and our appraisal of the pathogenesis of cerebellar tremor. The cerebellum occupies a central position to optimize behaviour, motor control, timing procedures and to prevent body oscillations. More than ever, the cerebellum is now considered as a major actor on the scene of disorders affecting the CNS, extending from motor disorders to cognitive and affective disorders. However, the respective roles of the mossy fibres, the climbing fibres, cerebellar cortex and cerebellar nuclei remains unknown or partially known at best in most cases. Research is now moving towards a better definition of the roles of cerebellar modules and microzones. This will impact on the management of cerebellar disorders

Turbulent slurry flow measurement using ultrasonic Doppler method in rectangular pipe

Distribution of velocity and Reynolds stress was measured using ultrasonic velocimetry in flows of water and Newtonian water-ballotini slurries in a pressurized Plexiglas pipe. Profiles of the measured parameters were sensed in the vertical plane at the centreline of a rectangular cross section of the pipe. Reference measurements in clear water produced expected symmetrical velocity profiles the shape of which was affected by secondary currents developed in the rectangular pipe. Slurry-flow experiments provided information on an effect of the concentration of solid grains on the internal structure of the flow. Strong attenuation of velocity fluctuations caused by a presence of grains was identified. The attenuation increased with the increasing local concentration of the grains

Gauge-adjusted rainfall estimates from commercial microwave links

Increasing urbanization makes it more and more important to have accurate stormwater runoff predictions, especially with potentially severe weather and climatic changes on the horizon. Such stormwater predictions in turn require reliable rainfall information. Especially for urban centres, the problem is that the spatial and temporal resolution of rainfall observations should be substantially higher than commonly provided by weather services with their standard rainfall monitoring networks. Commercial microwave links (CMLs) are non-traditional sensors, which have been proposed about a decade ago as a promising solution. CMLs are line-of-sight radio connections widely used by operators of mobile telecommunication networks. They are typically very dense in urban areas and can provide path-integrated rainfall observations at sub-minute resolution. Unfortunately, quantitative precipitation estimates (QPEs) from CMLs are often highly biased due to several epistemic uncertainties, which significantly limit their usability. In this manuscript we therefore suggest a novel method to reduce this bias by adjusting QPEs to existing rain gauges. The method has been specifically designed to produce reliable results even with comparably distant rain gauges or cumulative observations. This eliminates the need to install reference gauges and makes it possible to work with existing information. First, the method is tested on data from a dedicated experiment, where a CML has been specifically set up for rainfall monitoring experiments, as well as operational CMLs from an existing cellular network. Second, we assess the performance for several experimental layouts of ground truth from rain gauges (RGs) with different spatial and temporal resolutions. The results suggest that CMLs adjusted by RGs with a temporal aggregation of up to 1 h (i) provide precise high-resolution QPEs (relative error  < 7 %, Nash–Sutcliffe efficiency coefficient  >  0.75) and (ii) that the combination of both sensor types clearly outperforms each individual monitoring system. Unfortunately, adjusting CML observations to RGs with longer aggregation intervals of up to 24 h has drawbacks. Although it substantially reduces bias, it unfavourably smoothes out rainfall peaks of high intensities, which is undesirable for stormwater management. A similar, but less severe, effect occurs due to spatial averaging when CMLs are adjusted to remote RGs. Nevertheless, even here, adjusted CMLs perform better than RGs alone. Furthermore, we provide first evidence that the joint use of multiple CMLs together with RGs also reduces bias in their QPEs. In summary, we believe that our adjustment method has great potential to improve the space–time resolution of current urban rainfall monitoring networks. Nevertheless, future work should aim to better understand the reason for the observed systematic error in QPEs from CMLs

Linking Essential Tremor to the Cerebellum: Physiological Evidence.

Essential tremor (ET), clinically characterized by postural and kinetic tremors, predominantly in the upper extremities, originates from pathological activity in the dynamic oscillatory network comprising the majority of nodes in the central motor network. Evidence indicates dysfunction in the thalamus, the olivocerebellar loops, and intermittent cortical engagement. Pathology of the cerebellum, a structure with architecture intrinsically predisposed to oscillatory activity, has also been implicated in ET as shown by clinical, neuroimaging, and pathological studies. Despite electrophysiological studies assessing cerebellar impairment in ET being scarce, their impact is tangible, as summarized in this review. The electromyography-magnetoencephalography combination provided the first direct evidence of pathological alteration in cortico-subcortical communication, with a significant emphasis on the cerebellum. Furthermore, complex electromyography studies showed disruptions in the timing of agonist and antagonist muscle activation, a process generally attributed to the cerebellum. Evidence pointing to cerebellar engagement in ET has also been found in electrooculography measurements, cerebellar repetitive transcranial magnetic stimulation studies, and, indirectly, in complex analyses of the activity of the ventral intermediate thalamic nucleus (an area primarily receiving inputs from the cerebellum), which is also used in the advanced treatment of ET. In summary, further progress in therapy will require comprehensive electrophysiological and physiological analyses to elucidate the precise mechanisms leading to disease symptoms. The cerebellum, as a major node of this dynamic oscillatory network, requires further study to aid this endeavor.SCOPUS: re.jinfo:eu-repo/semantics/publishe