2,616 research outputs found
Antigenic variation in vector-borne pathogens.
Several pathogens of humans and domestic animals depend on hematophagous arthropods to transmit them from one vertebrate reservoir host to another and maintain them in an environment. These pathogens use antigenic variation to prolong their circulation in the blood and thus increase the likelihood of transmission. By convergent evolution, bacterial and protozoal vector-borne pathogens have acquired similar genetic mechanisms for successful antigenic variation. Borrelia spp. and Anaplasma marginale (among bacteria) and African trypanosomes, Plasmodium falciparum, and Babesia bovis (among parasites) are examples of pathogens using these mechanisms. Antigenic variation poses a challenge in the development of vaccines against vector-borne pathogens
The geometry of the Barbour-Bertotti theories I. The reduction process
The dynamics of interacting particles is investigated in the
non-relativistic context of the Barbour-Bertotti theories. The reduction
process on this constrained system yields a Lagrangian in the form of a
Riemannian line element. The involved metric, degenerate in the flat
configuration space, is the first fundamental form of the space of orbits of
translations and rotations (the Leibniz group). The Riemann tensor and the
scalar curvature are computed by a generalized Gauss formula in terms of the
vorticity tensors of generators of the rotations. The curvature scalar is
further given in terms of the principal moments of inertia of the system. Line
configurations are singular for . A comparison with similar methods in
molecular dynamics is traced.Comment: 15 pages, to appear in Classical and Quantum Gravit
Recommended from our members
Genomes, expression profiles, and diversity of mitochondria of the White-footed Deermouse Peromyscus leucopus, reservoir of Lyme disease and other zoonoses.
The cricetine rodents Peromyscus leucopus and P. maniculatus are key reservoirs for several zoonotic diseases in North America. We determined the complete circular mitochondrial genome sequences of representatives of 3 different stock colonies of P. leucopus, one stock colony of P. maniculatus and two wild populations of P. leucopus. The genomes were syntenic with that of the murids Mus musculus and Rattus norvegicus. Phylogenetic analysis confirmed that these two Peromyscus species are sister taxa in a clade with P. polionotus and also uncovered a distinction between P. leucopus populations in the eastern and the central United States. In one P. leucopus lineage four extended regions of mitochondrial pseudogenes were identified in the nuclear genome. RNA-seq analysis revealed transcription of the entire genome and differences from controls in the expression profiles of mitochondrial genes in the blood, but not in liver or brain, of animals infected with the zoonotic pathogen Borrelia hermsii. PCR and sequencing of the D-loop of the mitochondrion identified 32 different haplotypes among 118 wild P. leucopus at a Connecticut field site. These findings help to further establish P. leucopus as a model organism for studies of emerging infectious diseases, ecology, and in other disciplines
Foundations of Relational Particle Dynamics
Relational particle dynamics include the dynamics of pure shape and cases in
which absolute scale or absolute rotation are additionally meaningful. These
are interesting as regards the absolute versus relative motion debate as well
as discussion of conceptual issues connected with the problem of time in
quantum gravity. In spatial dimension 1 and 2 the relative configuration spaces
of shapes are n-spheres and complex projective spaces, from which knowledge I
construct natural mechanics on these spaces. I also show that these coincide
with Barbour's indirectly-constructed relational dynamics by performing a full
reduction on the latter. Then the identification of the configuration spaces as
n-spheres and complex projective spaces, for which spaces much mathematics is
available, significantly advances the understanding of Barbour's relational
theory in spatial dimensions 1 and 2. I also provide the parallel study of a
new theory for which positon and scale are purely relative but orientation is
absolute. The configuration space for this is an n-sphere regardless of the
spatial dimension, which renders this theory a more tractable arena for
investigation of implications of scale invariance than Barbour's theory itself.Comment: Minor typos corrected; references update
Triangleland. I. Classical dynamics with exchange of relative angular momentum
In Euclidean relational particle mechanics, only relative times, relative
angles and relative separations are meaningful. Barbour--Bertotti (1982) theory
is of this form and can be viewed as a recovery of (a portion of) Newtonian
mechanics from relational premises. This is of interest in the absolute versus
relative motion debate and also shares a number of features with the
geometrodynamical formulation of general relativity, making it suitable for
some modelling of the problem of time in quantum gravity. I also study
similarity relational particle mechanics (`dynamics of pure shape'), in which
only relative times, relative angles and {\sl ratios of} relative separations
are meaningful. This I consider firstly as it is simpler, particularly in 1 and
2 d, for which the configuration space geometry turns out to be well-known,
e.g. S^2 for the `triangleland' (3-particle) case that I consider in detail.
Secondly, the similarity model occurs as a sub-model within the Euclidean
model: that admits a shape--scale split. For harmonic oscillator like
potentials, similarity triangleland model turns out to have the same
mathematics as a family of rigid rotor problems, while the Euclidean case turns
out to have parallels with the Kepler--Coulomb problem in spherical and
parabolic coordinates. Previous work on relational mechanics covered cases
where the constituent subsystems do not exchange relative angular momentum,
which is a simplifying (but in some ways undesirable) feature paralleling
centrality in ordinary mechanics. In this paper I lift this restriction. In
each case I reduce the relational problem to a standard one, thus obtain
various exact, asymptotic and numerical solutions, and then recast these into
the original mechanical variables for physical interpretation.Comment: Journal Reference added, minor updates to References and Figure
Do consumers âGet the factsâ? A survey of alcohol warning label recognition in Australia
BACKGROUND: There is limited research on awareness of alcohol warning labels and their effects. The current study examined the awareness of the Australian voluntary warning labels, the âGet the factsâ logo (a component of current warning labels) that directs consumers to an industry-designed informational website, and whether alcohol consumers visited this website. METHODS: Participants aged 18â45 (unweighted nâ=â561; mean ageâ=â33.6Â years) completed an online survey assessing alcohol consumption patterns, awareness of the âGet the factsâ logo and warning labels, and use of the website. RESULTS: No participants recalled the âGet the factsâ logo, and the recall rate of warning labels was 16Â % at best. A quarter of participants recognised the âGet the factsâ logo, and awareness of the warning labels ranged from 13.1â37.9Â %. Overall, only 7.3Â % of respondents had visited the website. Multivariable logistic regression models indicated that younger drinkers, increased frequency of binge drinking, consuming alcohol directly from the bottle or can, and support for warning labels were significantly, positively associated with awareness of the logo and warning labels. While an increased frequency of binge drinking, consuming alcohol directly from the container, support for warning labels, and recognition of the âGet the factsâ logo increased the odds of visiting the website. CONCLUSIONS: Within this sample, recall of the current, voluntary warning labels on Australian alcohol products was non-existent, overall awareness was low, and few people reported visiting the DrinkWise website. It appears that current warning labels fail to effectively transmit health messages to the general public
Cosmology as Relativistic Particle Mechanics: From Big Crunch to Big Bang
Cosmology can be viewed as geodesic motion in an appropriate metric on an
`augmented' target space; here we obtain these geodesics from an effective
relativistic particle action. As an application, we find some exact (flat and
curved) cosmologies for models with N scalar fields taking values in a
hyperbolic target space for which the augmented target space is a Milne
universe. The singularities of these cosmologies correspond to points at which
the particle trajectory crosses the Milne horizon, suggesting a novel
resolution of them, which we explore via the Wheeler-deWitt equation.Comment: 17 pages, 3 figures, references and comments adde
Dense Quarks, and the Fermion Sign Problem, in a SU(N) Matrix Model
We study the effect of dense quarks in a SU(N) matrix model of deconfinement.
For three or more colors, the quark contribution to the loop potential is
complex. After adding the charge conjugate loop, the measure of the matrix
integral is real, but not positive definite. In a matrix model, quarks act like
a background Z(N) field; at nonzero density, the background field also has an
imaginary part, proportional to the imaginary part of the loop. Consequently,
while the expectation values of the loop and its complex conjugate are both
real, they are not equal. These results suggest a possible approach to the
fermion sign problem in lattice QCD.Comment: 9 pages, 3 figure
DNA characterization of Lyme disease spirochetes.
Lyme disease spirochetes (LDS) have phenotypic characteristics of both treponemes and borreliae. To ascertain whether one or more species of LDS exist, as well as their taxonomic status, we determined the DNA base (G + C) content for three strains of LDS, the DNA relatedness of ten strains isolated in the United States or Europe, and the DNA relatedness of LDS to other spirochetes. The G + C content of the three LDS strains was 28.1-29.0 mol%, most similar to those of Borellia hermsii (30.6 mol %) and Treponema hyodysenteriae (25.6 mol %) among the other spirochetes tested. DNA hybridization studies of nine LDS strains to a reference strain isolated from human blood revealed divergence (unpaired bases) within related nucleotide sequences of only 0.0-1.0 percent, indicating the strains were one species. Similarly, relatedness values of seven strains to the reference strain were high: 58-98 percent (mean, 71 percent) in 50 degrees C reactions and 50-93 percent (mean, 69 percent) in 65 degrees C reactions. Labeled DNA from B. hermsii was 30-40 percent related to three Lyme disease spirochete strains in 50 degrees C reactions and 8-10 percent related in 65 degrees C reactions. In contrast, DNA from the reference LDS strain showed relatedness of only 1 percent to DNAs of two leptospires and only 16 percent to DNA from T. hyodysenteriae. We conclude that LDS are a single species, genetically unlike treponemes or leptospires, which belong in the genus Borrelia
- âŠ