Analysis of the Localization Error for Capsule Endoscopy Applications at UWB Frequencies

Localization for Wireless Capsule Endoscopy (WCE) in the Ultra-Wideband frequency band is a very active field of investigation due to its potential advantages in future endoscopy applications. Received Signal Strength (RSS) based localization is commonly preferred due to its simplicity. Previous studies on Ultra-Wideband (UWB) RSS-based localization showed that the localization accuracy depends on the average ranging error related to the selected combination of receivers, which not always is the one experiencing the highest level of received power. In this paper the tendency of the localization error is further investigated through supplementary software simulations and previously conducted laboratory measurements. Two-dimensional (2D) and three-dimensional (3D) positioning are performed and the trend of the localization error compared in both cases. Results shows that the distribution of the selected path loss values, corresponding to the receivers used for localization, around the in-body position to estimate also affects the localization accuracy.This work was supported by the H2020:MSCA:ITN program for the “Wireless In-body Environment Communication- WiBEC” project under the grant agreement no. 675353. This work was also supported by the European Union’s H2020:MSCA:ITN program for the ”mmWave Communications in the Built Environments - WaveComBE” project under the grant agreement no. 766231.Barbi, M.; Pérez-Simbor, S.; Garcia-Pardo, C.; Cardona Marcet, N. (2019). Analysis of the Localization Error for Capsule Endoscopy Applications at UWB Frequencies. IEEE. https://doi.org/10.1109/ISMICT.2019.8743813

Safety and Efficacy Associated With a Family-Centered Procedural Sedation Protocol for Children With Autism Spectrum Disorder or Developmental Delay

Routine health care, whether physical examinations, blood sampling, vaccination, or dental care, is challenging and often traumatic for children with autism spectrum disorder (ASD) and children with developmental delay (DD), often requiring physical restraint or being indefinitely postponed. Behavioral interventions are critical for effective treatment of these children; however, in many children who have had traumatic medical experiences, these interventions may not be successful.1 Pharmacologic treatment with oral sedatives may be insufficient to perform common minor procedures, while the intramuscular route, requiring physical restraint for administration, can deepen the fear and lack of trust these children have toward the health care system.2 We describe a consecutive case series using a family-centered integrated behavioral and sedation protocol for common medical procedures in these children

Initial UWB in-body channel characterization using a novel multilayer phantom measurement setup

[EN] Wireless Body Area Networks (WBANs) are a promising technology for medical purposes. Currently the WBAN are classified into: implanted (in-), surface (on-) or outside (off-) body communications regarding the location of the devices with reference to the human body. The Ultra Wide-Band (UWB) frequency band is growing as a band of interest for implanted communications because of its high data rate and low power consumption among other benefits. Software simulations, in-vivo measurements and experimental phantom measurements are common methods to properly characterize the propagation channel. Nevertheless, up to now, experimental phantoms measurements presented in the literature show some inconveniences, i.e., the accuracy of the phantoms compared with the real human tissues or the testbed used for the measurements. This paper aims at overcoming these issues using accurate phantoms designed for the purpose of implanted communications in the UWB frequency band. In addition, a multilayer phantom container was developed. This container has capacity for two different phantoms, emulating a heterogeneous propagation medium for in-body measurements. Moreover, a novel setup was built for in-body phantom measurements. As a result, an experimental path loss model is presented from the measurements obtained with phantoms. Besides, software simulations mimicking the experimental setup are performed in order to validate the previous results obtainedThis work was supported by the European Union's H2020:MSCA:ITN program for the "Wireless In-body Environment Communication-WiBEC" project under the grant agreement no. 675353. this work was also funded by the Programa de Ayudas de Investigación y Desarrollo 8PAID-01-16) from Univeristat Politècnica de València and by the Ministerio de Economía y Competitividad, Spain (TEC2014-60258-C2-1-R), by the European FEDER funds.Pérez-Simbor, S.; Barbi, M.; Garcia-Pardo, C.; Castelló-Palacios, S.; Cardona Marcet, N. (2018). Initial UWB in-body channel characterization using a novel multilayer phantom measurement setup. IEEE. 384-389. https://doi.org/10.1109/WCNCW.2018.8369011S38438

Localization for capsule endoscopy at UWB frequencies using an experimental multilayer phantom

[EN] Localization inside the human body using ultrawideband (UWB) wireless technology is gaining importance in several medical applications such as capsule endoscopy. Performance analysis of RF based localization techniques are mainly conducted through simulations using numerical human models or through experimental measurements using homogeneous phantoms. One of the most common implemented RF localization approaches uses the received signal strength (RSS). However, to the best of our knowledge, no experimental measurements employing multilayer phantoms are currently available in literature. This paper investigates the performance of RSS-based technique for two-dimensional (2D) localization by employing a two-layer experimental phantom-based setup. Preliminary results on the estimation of the in-body antenna coordinates show that RSS-based method can achieve a location accuracy on average of 0.5-1 cm within a certain range of distances between in-body and on-body antenna.This work was supported by the European Union’s H2020:MSCA:ITN program for the ”Wireless In-body Environment Communication- WiBEC” project under the grant agreement no. 675353. This work was also funded by the Programa de Ayudas de Investigación y Desarrollo (PAID-01-16) from Universitat Politècnica de València and by the Ministerio de Economía y Competitividad, Spain (TEC2014-60258-C2-1-R), by the European FEDER funds.Barbi, M.; Pérez Simbor, S.; García Pardo, C.; Andreu Estellés, C.; Cardona Marcet, N. (2018). Localization for capsule endoscopy at UWB frequencies using an experimental multilayer phantom. Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/WCNCW.2018.8369015

Impact of Receivers Location on the Accuracy of Capsule Endoscope Localization

[EN] In recent years, localization for capsule endoscopy applications using Ultra-Wideband (UWB) technology has become an attractive field of study due to its potential benefits for patients. Performance analysis of RF-based localization techniques are very limited in literature. Most of the available studies rely on software simulations using digital human models. Nonetheless, no realistic studies based on in-vivo measurements has been reported yet. This paper investigates the performance of RSS-based technique for three-dimensional (3D) localization in the UWB frequency band. Impact of receivers selection as well as of the evaluated path loss model on the localization accuracy is investigated. Results obtained through CST-based simulations and from recently conducted in-vivo measurements are presented and compared.This work was supported by the European Union's H2020:MSCA:ITN program for the "Wireless In-body Environment Communication- WiBEC" project under the grant agreement no. 675353. This work was also funded by the Ministerio de Economia y Competitividad, Spain (TEC2014-60258-C2-1-R), by the European FEDER funds.Barbi, M.; Garcia-Pardo, C.; Cardona Marcet, N.; Andrea Nevárez; Vicente Pons Beltrán; Frasson, M. (2018). Impact of Receivers Location on the Accuracy of Capsule Endoscope Localization. IEEE. 340-344. https://doi.org/10.1109/PIMRC.2018.8580862S34034

Prevalence and characteristics of thelarche variant

Introduction: Girls with early thelarche may show an intermediate clinical picture between isolated premature thelarche (PT) and central precocious puberty (CPP), defined as “thelarche variant” (TV), characterized by an FSH-predominant response, although a univocal definition is lacking. Methods: Retrospective analysis on 91 girls with early thelarche (<8 years) and advanced bone age and/or accelerated growth who underwent 104 LHRH tests. Patients were classified into CPP (LH peak ≥5 IU/L; n = 28, 31%), TV (FSH peak ≥20 IU/L, LH peak <5 IU/L; n = 15, 16%), or PT (FSH peak <20 IU/L and LH peak <5 IU/L; n = 48, 53%). Results: TV patients were younger (5.51 years) and with less advanced bone age (+0.8 years). They had higher basal and peak FSH (2.5 and 26.6 IU/L) and lower basal and peak LH/FSH ratios (0.08 and 0.11). The prevalence of presence of ovarian follicles >5 mm in TV (42%) was similar to CPP but significantly higher than PT, whereas maximum ovarian volume was smaller in TV (1.0 cm3). At the last follow-up visit (available in 60% of the cases), 44% of TV developed CPP compared with 14% of PT (p = 0.04). At first evaluation, those who progressed to CPP had a higher basal FSH (3.2 IU/L), lower LH/FSH ratio (0.07), and a higher peak LH (4.1 IU/L) compared with those who did not progress to CPP (basal FSH 1.9 IU/L, p < 0.01; basal LH/FSH ratio 0.12, p < 0.01; peak LH 2.8 IU/L, p = 0.02). Conclusion: Using laboratory parameters only as a definition, we identified the clinical, laboratory, and imaging features of TV: these girls showed less advanced bone age and FSH predominance also at baseline, with smaller ovaries but with follicles >5 mm. Almost half of girls initially diagnosed as TV developed CPP at last follow-up visit, and these girls had higher baseline FSH, lower baseline LH/FSH ratio, and higher peak LH at first evaluation. Therefore, TV may represent a “precocious prepuberty” in which the FSH predominance may initially limit the progression into proper puberty, but it may eventually trigger full puberty (even CPP, depending on the girls’ age)

UWB RSS-based Localization for Capsule Endoscopy using a Multilayer Phantom and In Vivo Measurements

[EN] In recent years, the localization for capsule endoscopy applications using ultrawideband (UWB) technology has become an attractive field of investigation due to its potential benefits for patients. The literature concerning performance analysis of radio frequency-based localization techniques for in-body applications at UWB frequencies is very limited. Available studies mainly rely on finite-difference time-domain simulations, using digital human models and on experimental measurements by means of homogeneous phantoms. Nevertheless, no realistic analysis based on multilayer phantom measurements or through in vivo experiment has been reported yet. This paper investigates the performance of the received signal strength-based approach for 2-D and 3-D localizations in the UWB frequency band. For 2-D localization, experimental laboratory measurements using a two-layer phantom-based setup have been conducted. For 3-D localization, data from a recently conducted in vivo experiment have been used. Localization accuracy using path loss models, under ideal and non-ideal channel estimation assumptions, is compared. Results show that, under nonideal channel assumption, the relative localization error slightly increases for the 2-D case but not for the in vivo 3-D case. Impact of receivers selection on the localization accuracy has also been investigated for both 2-D and 3-D cases.This work was supported in part by the European Union's H2020 through the MSCA: ITN Program "Wireless in-Body Environment Communication-WiBEC" under Grant 675353, in part by the Programa de Ayudas de Investigacion y Desarrollo, Universitat Politecnica de Valencia under Grant PAID-01-16, and in part by the Ministerio de Economia y Competitividad, Spain, through the European FEDER Funds under Grant TEC2014-60258-C2-1-R.Barbi, M.; Garcia-Pardo, C.; Nevárez, A.; Pons Beltrán, V.; Cardona Marcet, N. (2019). UWB RSS-based Localization for Capsule Endoscopy using a Multilayer Phantom and In Vivo Measurements. IEEE Transactions on Antennas and Propagation. 67(8):5035-5043. https://doi.org/10.1109/TAP.2019.2916629S5035504367

Invasive Infections Associated with the Use of Probiotics in Children: A Systematic Review.

Although the effectiveness of probiotics has only been proven in specific conditions, their use in children is massively widespread because of their perception as harmless products. Recent evidence raises concerns about probiotics' safety, especially but not only in the paediatric population due to severe opportunistic infections after their use. This review aimed at summarising available case reports on invasive infections related to probiotics' use in children. For this purpose, we assessed three electronic databases to identify papers describing paediatric patients with documented probiotic-derived invasive infections, with no language restrictions. A total of 49 case reports from 1995 to June 2021 were identified. The infections were caused by Lactobacillus spp. (35%), Saccharomyces spp. (29%), Bifidobacterium spp. (31%), Bacillus clausii (4%), and Escherichia coli (2%). Most (80%) patients were younger than 2 years old and sepsis was the most observed condition (69.4%). All the patients except one had at least one condition facilitating the development of invasive infection, with prematurity (55%) and intravenous catheter use (51%) being the most frequent. Three (6%) children died. Given the large use of probiotics, further studies aiming at evaluating the real incidence of probiotic-associated systemic infections are warranted

Ultrawideband Technology for Medical In-Body Sensor Networks: An Overview of the Human Body as a Propagation Medium, Phantoms, and Approaches for Propagation Analysis

[EN] An in-body sensor network is that in which at least one of the sensors is located inside the human body. Such wireless in-body sensors are used mainly in medical applications, collecting and monitoring important parameters for health and disease treatment. IEEE Standard 802.15.6-2012 for wireless body area networks (WBANs) considers in-body communications in the Medical Implant Communications Service (MICS) band. Nevertheless, high-data-rate communications are not feasible at the MICS band because of its narrow occupied bandwidth. In this framework, ultrawideband (UWB) systems have emerged as a potential solution for in-body highdata-rate communications because of their miniaturization capabilities and low power consumption.This work was supported by the Programa de Ayudas de Investigación y Desarrollo (PAID-01-16) at the Universitat Politècnica de València, Spain; by the Ministerio de Economía y Competitividad, Spain (TEC2014-60258-C2-1-R); and by the European FEDER funds. It was also funded by the European Union’s H2020:MSCA:ITN program for the Wireless In-Body Environ-ment Communication–WiBEC project under grant 675353.Garcia-Pardo, C.; Andreu-Estellés, C.; Fornés Leal, A.; Castelló-Palacios, S.; Pérez-Simbor, S.; Barbi, M.; Vallés Lluch, A.... (2018). Ultrawideband Technology for Medical In-Body Sensor Networks: An Overview of the Human Body as a Propagation Medium, Phantoms, and Approaches for Propagation Analysis. IEEE Antennas and Propagation Magazine. 60(3):19-33. https://doi.org/10.1109/MAP.2018.2818458S193360

USING BLACK SOLDIER FLIES (HERMETIA ILLUCENS) TO BIOCONVERT WASTE FROM THE LIVESTOCK PRODUCTION CHAIN: A LIFE CYCLE ASSESSMENT CASE STUDY

The aim of this study was to enhance waste from the livestock production chain using insects to produce biomaterials that can fall within the agricultural production cycle (e.g. plastic mulch), in order to achieve sustainability throughout the technological process. After stabilization by drying, mature larvae of Hermetia illucens reared on substrate composed of poultry manure, zeolite and water were chemically separated in the laboratory to extract the proteic, lipidic and chitinic fractions. Proteins were then isolated and added to other components in order to obtain bioplastics. The environmental impacts of the bioplastic production process developed at a laboratory scale was evaluated through the LCA methodology