11 research outputs found
High Levels of DEK Autoantibodies in Sera of Patients With Polyarticular Juvenile Idiopathic Arthritis and With Early Disease Flares Following Cessation of Antiâ Tumor Necrosis Factor Therapy
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142962/1/art40404_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/142962/2/art40404-sup-0001-Supinfo.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/142962/3/art40404.pd
Correction: Stoll et al. Impact of HLA-B27 and Disease Status on the Gut Microbiome of the Offspring of Ankylosing Spondylitis Patients. <i>Children</i> 2022, <i>9</i>, 569
The authors wish to make the following correction to this paper [...
Impact of HLA-B27 and Disease Status on the Gut Microbiome of the Offspring of Ankylosing Spondylitis Patients
Multiple studies have shown the microbiota to be abnormal in patients with spondyloarthri-tis (SpA). The purpose of this study was to explore the genetic contributions of these microbiota abnormalities. We analyzed the impact of HLA-B27 on the microbiota of children at risk for SpA and compared the microbiota of HLA-B27+ pediatric offspring of ankylosing spondylitis (AS) patients with that of HLA-B27+ children with SpA. Human DNA was obtained from the offspring for determination of HLA-B27 status and polygenic risk score (PRS). Fecal specimens were collected from both groups for sequencing of the V4 region of the 16S ribosomal RNA gene. Among the offspring of AS patients, there was slight clustering by HLA-B27 status. After adjusting for multiple comparisons, five operational taxonomic units (OTUs) representing three unique taxa distinguished the HLA-B27+ from negative children: Blautia and Coprococcus were lower in the HLA-B27+ offspring, while Faecalibacterium prausnitzii was higher. HLA-B27+ offspring without arthritis were compared to children with treatment-naïve HLA-B27+ SpA. After adjustments, clustering by diagnosis was present. A total of 21 OTUs were significantly associated with diagnosis state, including Bacteroides (higher in SpA patients) and F. prausnitzii (higher in controls). Thus, our data confirmed associations with B fragilis and F prausnitzii with juvenile SpA, and also suggest that the mechanism by which HLA-B27 is associated with SpA may not involve alterations of the microbiota.</p
Additional file 1: of Age and fecal microbial strain-specific differences in patients with spondyloarthritis
Code for processing of 16S sequences with DADA2 and for shotgun sequence analysis with HUMAnN2. (DOCX 12 kb
2021 American College of Rheumatology Guideline for the Treatment of Juvenile Idiopathic Arthritis: Therapeutic Approaches for Oligoarthritis, Temporomandibular Joint Arthritis, and Systemic Juvenile Idiopathic Arthritis
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/172047/1/art42037.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/172047/2/art42037-sup-0001-Disclosureform.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/172047/3/art42037_am.pd
2021 American College of Rheumatology Guideline for the Treatment of Juvenile Idiopathic Arthritis: Recommendations for Nonpharmacologic Therapies, Medication Monitoring, Immunizations, and Imaging
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/171978/1/art42036-sup-0001-Disclosureform.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/171978/2/art42036.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/171978/3/art42036_am.pd
2021 American College of Rheumatology Guideline for the Treatment of Juvenile Idiopathic Arthritis: Therapeutic Approaches for Oligoarthritis, Temporomandibular Joint Arthritis, and Systemic Juvenile Idiopathic Arthritis
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/172074/1/acr24853.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/172074/2/acr24853_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/172074/3/acr24853-sup-0001-Disclosureform.pd