Flt-3 ligand kinetics as an example of biomarker with long time window of relevance.

<p>The averaged values of TBI animals are significantly higher than PBI animals from 3d after exposure (*p<0.05) and peak 21d post-exposure (**p<0.01 and ***p<0.001).</p

DIC assay estimations of the percentage of circulating blood exposed from a sample taken 1 day after exposure.

<p>LP = Legs Protected. HP = Head Protected.</p><p>DIC assay estimations of the percentage of circulating blood exposed from a sample taken 1 day after exposure.</p

Validation of the animal exposure model using PLSDA.

<p>a) The R2 value of a given model may be used to assess its degree of fit to the data (99.8%) and the Q2 value of the model is used to assess the predictive power of the model (82.0%). b) Scores plot showing a clear distinction of 5Gy TBI animals from the 5 Gy equivalent PBI. LP = Legs Protected. HP = Head Protected.</p

Kinetics of Creatine Kinase (CK) as an example of an early biomarker.

<p>The average of CK values of TBI animals are significantly higher than PBI animals from 1d after exposure (*p<0.05; **p<0.01; ***p<0.001).</p

Hematopoietic bone marrow (BM) colony-forming units from exposed and shielded humerus.

<p>The values here represented are the average of the 2 animals of each exposure group. The exposed areas showed a dose-dependent decrease 1d after exposure and there’s a start of recovery at 42d. In the legend “10 Gy 50% PBI exposed side” refers to bone marrow cells extracted from the exposed side of the animal subjected to a 10 Gy 50% PBI. “10 Gy 50% PBI shielded side” refers to bone marrow cells extracted from the shielded side of the animal (shielded using a 20 cm thick lead screen) subjected to a 10 Gy 50% PBI.</p