Number of isolation facilities, existence of High Level Isolation Units, and isolation beds for highly infectious patients per participating country.

<p>(#): Numbers in brackets indicate the amount of High Level Isolation Units per country, if existing. (*): Total population calculated on the basis of Eurostat <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0100401#pone.0100401-European3" target="_blank">[30]</a>. (§): Facilities enrolled are located in the Catalonia region, only.</p><p>Number of isolation facilities, existence of High Level Isolation Units, and isolation beds for highly infectious patients per participating country.</p

Access to specifically trained personnel.

<p>Number of facilities enrolled with access to specifically trained personnel (overall response n = 48/48). Access to Infectious Disease and Intensive Care doctors or nurses is provided in the majority of facilities, but specifically trained personnel for paediatric patients is rarely available.</p

Access to and location of Intensive Care beds for HID patients.

<p>Number of facilities enrolled with Intensive Care (IC) capacity and location of IC beds (overall response n = 48/48). 33 facilities provide IC beds within the isolation area, and 12 in designated rooms on standard IC wards.</p

Classification of enrolled facilities by adherence to EUNID recommendations.

<p>Number of facilities classified by adherence to published recommendations: 18/48 facilities fulfilled the criteria of ‘High Level Isolation Units’ (HLIU); 25 met criteria for ‘Isolation Rooms’ and 5 for ‘Referral Centres’.</p

Distribution of CATs, CURB-65 and PMEWS scores according to outcome measures (Level 2/3 admission, mortality, combined measure of severe outcomes) in adults (≥16 years).

*<p>Combined measure of severe outcomes (Level 2/3 admission or death).</p

Multivariable analyses of CAT criteria as independent predictors of outcomes in children (<16 years), forward stepwise regression.

<p>Values are adjusted odds ratios (95% confidence intervals), significant values in bold and p values in italic. Each predictor variable (CAT criterion) in model adjusted for other criteria in the multivariable model remaining following forward stepwise regression (significance level for addition to the model p≤0.05); * criteria excluded from the final model. X Not calculated as this criterion typically directs the outcome (use of supplemental oxygen).</p

The predictive values of CATs, CURB-65 and PMEWS for predicting severe outcomes in adults and children with pandemic influenza.

<p>ROC curves comparing the predictive value of CATs (black solid line), CURB-65 (grey dash line) and PMEWS (black dash line) in relation to Level 2/3 admissions (upper panels), mortality (middle panels) and combined severe outcomes (lower panels) in adults (left panels, age ≥16 years, n = 1040) and children (right panels, age<16 years, n = 480).</p

Predictive values of CATs, CURB-65 and PMEWS scores for predicting severe outcomes in adults (≥16 years, n = 1040).

*<p>Combined measure of severe outcomes (Level 2/3 admission or death).</p

Multivariable analyses of CAT criteria as independent predictors of outcomes in adults (≥16 years), forward stepwise regression.

<p>Values are adjusted odds ratios (95% confidence intervals), significant values in bold and p values in italic. Each predictor variable (CAT criterion) in model adjusted for other criteria in the multivariable model remaining following forward stepwise regression (significance level for addition to the model p≤0.05); X Not calculated as this criterion typically directs the outcome (use of supplemental oxygen).</p

Predictive values of CATs, CURB-65 and PMEWS scores for predicting severe outcomes in children (<16 years, n = 480).

*<p>Combined measure of severe outcomes (Level 2/3 admission or death).</p