Magnesium and hypertension in old age

Hypertension is a complex condition in which various actors and mechanisms combine, resulting in cardiovascular and cerebrovascular complications that today represent the most fre-quent causes of mortality, morbidity, disability, and health expenses worldwide. In the last decades, there has been an exceptional amount of experimental, epidemiological, and clinical studies confirm-ing a close relationship between magnesium deficit and high blood pressure. Multiple mechanisms may help to explain the bulk of evidence supporting a protective effect of magnesium against hypertension and its complications. Hypertension increases sharply with advancing age, hence older persons are those most affected by its negative consequences. They are also more frequently at risk of magnesium deficiency by multiple mechanisms, which may, at least in part, explain the higher frequency of hypertension and its long-term complications. The evidence for a favorable effect of magnesium on hypertension risk emphasizes the importance of broadly encouraging the intake of foods such as vegetables, nuts, whole cereals and legumes, optimal dietary sources of magnesium, avoiding processed food, which are very poor in magnesium and other fundamental nutrients, in order to prevent hypertension. In some cases, when diet is not enough to maintain an adequate magnesium status, magnesium supplementation may be of benefit and has been shown to be well tolerated

Magnesium in Type 2 Diabetes Mellitus, Obesity, and Metabolic Syndrome

not availabl

Polyphenol oxidase, total phenolics and ascorbic acid changes during storage of minimally processed 'California Wonder' and 'Quadrato d'Asti' sweet peppers

Abstract A growing sector of 'minimally processed' vegetables market is represented by sweet peppers, whose quality may be affected by enzymatic activities. Among these, polyphenol oxidase leads to browning reactions, which is a major cause of quality loss. This research aimed at assessing the changes in PPO activity, total phenolics and ascorbic acid throughout a 30-days cold storage in minimally processed green (cv. 'California Wonder'), yellow and red (cv. 'Quadrato d'Asti') sweet peppers. At day 0 PPO was active in red and yellow fruits but not in green ones, where it started to show relevant activity from the 3rd week of storage. At the end of the storage period (day 30), PPO activity was 1.36, 0.94 and 0.61 U/g d.m. in yellow, red and green peppers, respectively. Total phenols content was highest in green peppers, followed by red and yellow ones. In green fruits it increased up to the 3rd week of storage, decreasing afterwards, whilst in red and yellow fruits phenols content progressively declined after the 2nd week. Yellow fruits showed the highest ascorbic acid content, followed by red and green ones. Results confirm that green peppers 'California Wonder' are more suitable to minimal processing than yellow and red fruits

Effect of water cooking on proximate composition of grain in three Sicilian chickpeas (Cicer arietinum L.)

Abstract The aim of this study was to assess the effects of cooking upon proximate composition in three Sicilian chickpeas differing for seed-coat incidence ('12CL2'–low, 'Calia'–medium, 'Etna'–high). Raw and cooked seeds were analyzed for moisture, nitrogen, starch, ash, fat, tannins, crude fiber, magnesium, calcium and iron content. Among cultivars, 'Etna' (higher in seed-coat incidence) exhibited the greatest tannin content in raw seeds (>6 g kg −1 dry weight-DW). Cooking induced a drop in tannins. Protein content did not differ with cultivar in raw seeds (238.0 g kg −1 DW) but increased after cooking (+6%). Starch content was strongly reduced after cooking (−30% on average), irrespective of cultivar. Fat content (43.6 g kg −1 DW in raw seeds) did not vary with cultivar but increased with cooking. This last determined a decrease of ash content (−31.3% in average). Minerals diminished as well due to cooking process, but with a different extent depending on cultivar; iron content decreased in all chickpeas except 'Etna', calcium and magnesium content greatly diminished in '12Cl2' and 'Calia', less in 'Etna'. The higher rate of mineral retention of 'Etna' seeds could be attributed to their higher seed coat incidence

Stage III Kienböck's Disease Treated with Hyperbaric Oxygen: the Role of an Unusual Approach to a Rare Condition

Kienböck's disease is a rare condition characterised by avascular necrosis of the lunate bone. Its natural history and aetiopathogenesis have not yet been clarified, nor are its triggering factors identified. We present a case of a 17-year-old male gymnast, without relevant medical/family history, with stage IIIA Kienböck's disease diagnosed in 2016. Initially, submitted to conservative treatment that proved to be insufficient. Consequently, surgical treatment was proposed, but refused. The patient instead underwent experimental treatment with hyperbaric oxygen (120 sessions, 100% oxygen at 2.5 atm, for 70 min periods, once daily, five times per week). In April 2018, a favourable clinical and radiological evolution was observed, with an improvement in the patterns of pain, motion and strength and an almost complete involution of the process of aseptic necrosis of the semilunar. To the best of our knowledge, this is the first report of Kienböck's disease treated with hyperbaric oxygen.info:eu-repo/semantics/publishedVersio

The importance of prognosis in geriatric patients attending the emergency department: a comparison between two common short geriatric assessment tools

Background: The use of short geriatric tools in the emergency department (ED) is increasing, but the literature is still conflicting. The aim of this study is to compare the precision and the accuracy of two short geriatric assessment tools to predict mortality in a cohort of older patients attending the ED. Methods: A retrospective study was conducted including patients ≥ 65 years, attending the ED and transferred to a medical assessment unit from February to July 2022. Clinical Frailty Scale (CFS) and Brief Multidimensional Prognostic Index (Brief MPI) were administered. The association between Brief MPI and CFS and mortality was analysed via area under the curve (AUC) with its 95% confidence intervals (CIs), the C-statistics and a multivariate Cox’s regression analysis, in the latter case reporting the data as hazard ratios (HRs) with their 95% CI. Results: Among the 579 patients enrolled (mean age: 77 years), both Brief MPI and CFS showed a good accuracy in predicting mortality (AUC: 0.72; 95% CI: 0.61–0.83 for Brief MPI; 0.754; 95% CI: 0.65–0.83 for CFS). The discrimination of Brief MPI and CFS in predicting mortality was excellent, since the C-index of the Brief MPI was 0.85 and of CFS = 0.84. In the multivariate analysis, the risk for mortality was significantly increased for frailer subjects (HR 4.65; 95% CI: 1.45–15.00 for Brief MPI > 0.66; HR = 9.24; 95% CI: 1.16–76.90 for CFS > 6). Conclusions: Brief MPI and CFS showed a good accuracy/precision to predict mortality in older patients attending the ED. Considering that they are quick to perform, their introduction in ED clinical practice could be extremely helpful

Impact of mediterranean diet on chronic non-communicable diseases and longevity

The average life expectancy of the world population has increased remarkably in the past 150 years and it is still increasing. A long life is a dream of humans since the beginning of time but also a dream is to live it in good physical and mental condition. Nutrition research has focused on recent decades more on food combination patterns than on individual foods/nutrients due to the possible synergistic/antagonistic effects of the components in a dietary model. Various dietary patterns have been associated with health benefits, but the largest body of evidence in the literature is attributable to the traditional dietary habits and lifestyle followed by populations from the Mediterranean region. After the Seven Countries Study, many prospective observational studies and trials in diverse populations reinforced the beneficial effects associated with a higher adherence to the Mediterranean diet in reference to the prevention/management of age-associated non-communicable diseases, such as cardiovascular and metabolic diseases, neurodegenerative diseases, cancer, depression, respiratory diseases, and fragility fractures. In addition, the Mediterranean diet is ecologically sustainable. Therefore, this immaterial world heritage constitutes a healthy way of eating and living respecting the environment

Magnesium in infectious diseases in older people

Reduced magnesium (Mg) intake is a frequent cause of deficiency with age together with reduced absorption, renal wasting, and polypharmacotherapy. Chronic Mg deficiency may result in increased oxidative stress and low-grade inflammation, which may be linked to several age-related diseases, including higher predisposition to infectious diseases. Mg might play a role in the immune response being a cofactor for immunoglobulin synthesis and other processes strictly associated with the function of T and B cells. Mg is necessary for the biosynthesis, transport, and activation of vitamin D, another key factor in the pathogenesis of infectious diseases. The regulation of cytosolic free Mg in immune cells involves Mg transport systems, such as the melastatin-like transient receptor potential 7 channel, the solute carrier family, and the magnesium transporter 1 (MAGT1). The functional importance of Mg transport in immunity was unknown until the description of the primary immunodeficiency XMEN (X-linked immunodeficiency with Mg defect, Epstein–Barr virus infection, and neoplasia) due to a genetic deficiency of MAGT1 characterized by chronic Epstein–Barr virus infection. This and other research reporting associations of Mg deficit with viral and bacterial infections indicate a possible role of Mg deficit in the recent coronavirus disease 2019 (COVID-19) and its complications. In this review, we will discuss the importance of Mg for the immune system and for infectious diseases, including the recent pandemic of COVID-19

Oxidases activities and antioxidant capacity of minimally processed baby romaine lettuce (Lactuca sativa L. cv. duende) cultivated under different salinity conditions

[SPA] El pardeamiento enzimático es uno de los principales problemas implicados en el procesamiento mínimo y en la siguiente conservación de hortalizas de hoja, reduciendo la vida comercial del producto. Se han evaluado las variaciones de las dos principales oxidasas, polifenol oxidasa (PPO) y peroxidasa (POD), así como del contenido en fenoles, del color y de la capacidad antioxidante (metodo ORAC) durante 10 días de conservación a 4 °C de lechuga Baby Romaine (Lactuca sativa L. cv. Duende) mínimamente procesada, cultivada bajo 3 distintas condiciones de salinidad (2,8, 3,8, 4,8 dS/m), para determinar la condición más apta al siguiente procesamiento. Niveles crecientes de salinidad redujeron las dos actividades enzimáticas durante 7 días de conservación. En las muestras cultivadas en condición de elevada salinidad se observó también la menor variación de color, expresada como ΔE* [(ΔL*2+Δa*2+Δb*2)1/2], y la menor reducción de contenido en fenoles y de capacidad antioxidante en el día 3. [ENG] Enzymatic browning is a main problem involved in minimal processing and further storage of leafy vegetables, leading to shorter shelf-life of the product. Changes in the two oxidative activities, polyphenol oxidase (PPO) and peroxidase (POD), as well as in total phenolic content, colour parameters and antioxidant capacity (assayed with ORAC method), were monitored during 10 days of storage at 4 °C of minimally processed Baby Romaine lettuce (Lactuca sativa L. cv. Duende) cultivated under 3 different salinity conditions (2,8, 3,8, 4,8 dS/m), in order to determine the most suitable condition for further processing. Increasing levels of salinity reduced both oxidases activities immediately after cutting and throughout 7 days of storage. Samples cultivated under high salinity had also the lowest change in colour, expressed as ΔE* [(ΔL*2+Δa*2+Δb*2)1/2], and showed the lowest reduction in total phenolic content and antioxidant capacity after 3 days of storage

Prevalence of Sarcopenia in Knee Osteoarthritis: A Systematic Review and Meta-Analysis

An association between knee osteoarthritis (OA) and sarcopenia has been proposed, but the evidence is controversial, with the recent literature showing disparate results. Therefore, we aimed to perform a systematic review and meta-analysis to evaluate the prevalence of sarcopenia in knee OA patients compared to people not affected by this condition. We searched several databases until 22 February 2022. The data regarding prevalence were summarized using odds ratios (ORs) with their 95% confidence intervals (CIs). Among the 504 papers initially screened, 4 were included for a total of 7495 participants with a mean age of 68.4 years, who were mainly females (72.4%). The prevalence of sarcopenia in people with knee OA was 45.2%, whilst, in the controls, it was 31.2%. Pooling the data of the studies included that the prevalence of sarcopenia in knee OA was more than two times higher than in the control group (OR = 2.07; 95%CI: 1.43–3.00; I2 = 85%). This outcome did not suffer any publication bias. However, after removing an outlier study, the recalculated OR was 1.88. In conclusion, the presence of sarcopenia in knee OA patients was high, affecting one person in every two persons and was higher than in the control groups included