The effect of endurance training and taxol consumption on cyclooxygenase-2 and prostaglandin E2 levels in the liver tissue of mice with cervical cancer

Background: Herbs have a strong anti-cancer effect. Also, exercise is one of several lifestyle factors known to lower the risk of developing cancer. The aim of this study was to investigate the effect of endurance training and taxol on cyclooxygenase-2 and prostaglandin E2 in the liver tissue of mice with cervical cancer. Materials and Methods: In this experimental study, 35 female C57 mice were randomly divided into 5 groups (n=7 in each group): control (healthy), control (cancer), complement (cancer), training-supplementary (cancer) and training (cancer). The implantation of cancerous tumors was performed under the skin of the upper pelvis. The training group completed the endurance training protocol, which included 3 sessions per week, 50 minutes per session, at a speed of 14-18 m/s for six weeks. A dose of 60 mg/kg/day of pure taxol was injected intra peritoneally. The dependent variables of this study were measured 24 hours after the last training session by ELISA. Results: The results showed that the use of taxol and endurance training reduced the levels of cyclooxygenase-2 and prostaglandin E2 in the liver tissues of C57 mice with cervical cancer. Conclusion: Induction of the cancerous tissue in mice with cervical cancer increases the levels of cyclooxygenase-2 and prostaglandin E2 and endurance training along with taxol may reduce these levels

Evaluation the helicobacter pylori infection in asthmatic children compared to control group

Background: Asthma is a highly prevalent chronic respiratory disease in children. Moreover, the underlying causes of asthma exacerbation are important because they are effective in controlling and preventing asthma. The aim of this study was to evaluate the helicobacter pylori infection in controlled and uncontrolled asthmatic children compared to healthy children. Methods: This case- control study was done on 120 children aged 6-14 years with moderate to severe asthma. Diagnosis of asthma was performed according to GINA criteria with respect to the history and clinical examination. In addition, 120 healthy children without asthma were considered as the control group. Helicobacter pylori stool antigen test was evaluated for all patients. In addition to the above information, age, sex, duration of asthma and gastrointestinal symptoms were also recorded for each patient. Data were analyzed using SPSS15, Chi-square and Fisher's exact test and T-test. Results: The mean age of children in the asthmatic and healthy children was 8.3±2 and 8.5±2.3, respectively (p=0.479). Totally, 57.5% and 58.3% of children were boys in the control group, and in asthmatic group, respectively. Thirty percent of children in the control group and 8.3% of children with asthma were H. pylori positive (p=0.000). Mean duration of asthma in children with H. pylori positive (3.3±1.55) and H. pylori negative (3.33±1.56) stool antigen showed no significant difference (p=0.944). Conclusions: The results of this study indicated that there was an inverse relation between helicobacter pylori infection and asthma

Effects of conventional and ionic liquid-based surfactants and sodium tetraborate on interfacial tension of acidic crude oil

Abstract The application of a new class of surfactants such as ionic liquids (ILs) compared with the conventional surfactants and their interactions with each other concomitant and alkaline under salinities is not well examined based on the best knowledge of the authors. So, the current work focused on the impact of sodium lauryl sulfate (SDS), sodium dodecyl benzene sulfonate (SDBS), 1-dodecyl 3-methyl imidazolium chloride (C12mim][Cl]), 1-octadecyl 3-methyl imidazolium chloride ([C18mim][Cl]) in the presence and absence of alkali namely sodium tetraborate known as borax (Na2B4O7) on the IFT variation while the salinity was changed 0–82,000 ppm (ionic strength of 0–1.4 M). The results showed the positive impact of salinity on the pH reduction and reduced the alkaline effect for pH reduction. Also, the measurements showed that the presence of surfactant reduces the role of alkaline for pH variation as it moved from 9.2 to 6.63 for the solution prepared using SLS and SDBS. The measured IFT values showed that not only alkali has a significant impact as it combined with SLS and SDBS due to a desired synergy between these chemicals, it can reduce the critical micelle concentration (CMC) for the SDBS from 1105 to 852 ppm and much higher for [C12mim][Cl]

The Effect of Endurance Training and L-Carnitine Supplementation on Gene Expression of Hepatic Enzymes (AST,ALT,ALP) in Wistar Male Rats Toxicated by Boldenone

Background & Objective: The aim of this study was to investigate the effect of endurance training and L-carnitine supplementation on gene expression of hepatic enzymes (AST, ALT, ALP) in Wistar male rats toxicated by Boldenone. Materials & Methods: In this experimental study, 30 male Wistar rats aged 12 weeks (weight 195±7.94g) were randomly divided into five groups: control, no-treatment, boldenone (5mg/kg), L-carnitine and aerobic training- L-carnitine. The endurance moderate intensity training program (50-55% of maximal oxygen consumption) was performed for 6 weeks and 5 times a week. Boldenone injection once a week, on an appointed day, and in the hamstring was conducted in depth. After anesthesia, autopsy was performed and the liver was isolated. The hepatic enzymes gene expression in the samples were measured by Real Time PCR. Data were analyzed by t-test, One-way ANOVA and post hoc Scheffe at the significant level P<0.05. Results: The results showed that there was a significant difference between the mean expression of liver enzymes (AST, ALT, ALP) in male Wistar rats in different groups (P<0.001). The changes in liver enzymes gene expression (AST, ALT, ALP) in L-carnitine and Training-L-carnitine groups were significantly lower than the boldenone group (P<0.001). Conclusion: According to the findings of this study, supplementation of L-carnitine with regular aerobic training reduces liver damage induced by anabolic androgenic steroids.   Keywords