Hepatoprotective phenylethanoid glycosides from <i>Cirsium setosum</i>

<p>Two new phenylethanoid glycosides, namely <i>β</i>-D-glucopyranoside, 1″-<i>O</i>-(7<i>S</i>)-7-(3-methoxyl-4-hydroxyphenyl)-7-methoxyethyl-3″-<i>α</i>-L-rhamnopyranosyl-4″-[(8<i>E</i>)-7-(3-methoxyl-4-hydroxyphenyl)-8-propenoate] (<b>1</b>) and <i>β</i>-D-glucopyranoside, 1″-<i>O</i>-(7<i>S</i>)-7-(3-methoxyl-4-hydroxyphenyl)-7-methoxyethyl-3″-<i>α</i>-L-rhamnopyranosyl-4″-[(8<i>E</i>)-7-(4-hydroxyphenyl)-8-propenoate] (<b>2</b>), together with six phenylethanoid glycosides were isolated from <i>Cirsium setosum</i>. Their structures were elucidated by their spectroscopic data and references. Compounds <b>2</b>, <b>4</b>, <b>5</b>, <b>7</b> and <b>8</b> (10 μM) exhibited moderate hepatoprotective activities. Compounds (<b>3–8</b>) were obtained from this plant for the first time.</p