RESEARCH ON THE MOTION RESPONSE OF AQUACULTURE SHIP AND TANK SLOSHING UNDER ROLLING RESONANCE

The double-row and double-chamfered aquaculture tank is a special tank structure of the aquaculture ship. The tank sloshing of this structure is coupled with the hull motion, which has an important impact on the safety of the hull motion. In the present study, research on the tank sloshing and hull motion response of aquaculture ships was conducted based on the model seakeeping and tank sloshing tests in regular waves. The test results were compared with the numerical simulation results of solid loading without sloshing. The results showed that the numerical simulation of the pitch motion was consistent with the amplitude-frequency response curve of the experimental results. Under certain transverse wave conditions, a large discrepancy existed between the amplitude-frequency response curve of the heave motion by the numerical simulation and the test results, and the roll motion differed most from the experimental result. Severe roll resonance occurred when the wave length-ship length ratio was 0.6. The roll motion amplitude was increased by 183.2%. Therefore, compared with aquaculture ships without sloshing, the sloshing of the tank has little effect on the pitch but has a great impact on the roll and heave motions, with the most significant effect on the roll motion

HECT, UBA and WWE domain containing 1 represses cholesterol efflux during CD4+ T cell activation in Sjögren’s syndrome

Introduction: Sjögren’s syndrome (SS) is a chronic autoimmune disorder characterized by exocrine gland dysfunction, leading to loss of salivary function. Histological analysis of salivary glands from SS patients reveals a high infiltration of immune cells, particularly activated CD4+ T cells. Thus, interventions targeting abnormal activation of CD4+ T cells may provide promising therapeutic strategies for SS. Here, we demonstrate that Hect, uba, and wwe domain containing 1 (HUWE1), a member of the eukaryotic Hect E3 ubiquitin ligase family, plays a critical role in CD4+ T-cell activation and SS pathophysiology.Methods: In the context of HUWE1 inhibition, we investigated the impact of the HUWE1 inhibitor BI8626 and sh-Huwe1 on CD4+ T cells in mice, focusing on the assessment of activation levels, proliferation capacity, and cholesterol abundance. Furthermore, we examined the therapeutic potential of BI8626 in NOD/ShiLtj mice and evaluated its efficacy as a treatment strategy.Results: Inhibition of HUWE1 reduces ABCA1 ubiquitination and promotes cholesterol efflux, decreasing intracellular cholesterol and reducing the expression of phosphorylated ZAP-70, CD25, and other activation markers, culminating in the suppressed proliferation of CD4+ T cells. Moreover, pharmacological inhibition of HUWE1 significantly reduces CD4+ T-cell infiltration in the submandibular glands and improves salivary flow rate in NOD/ShiLtj mice.Conclusion: These findings suggest that HUWE1 may regulate CD4+ T-cell activation and SS development by modulating ABCA1-mediated cholesterol efflux and presents a promising target for SS treatment

Deep Convolutional Neural Network Phase Unwrapping for Fringe Projection 3D Imaging

Phase unwrapping is a very important step in fringe projection 3D imaging. In this paper, we propose a new neural network for accurate phase unwrapping to address the special needs in fringe projection 3D imaging. Instead of labeling the wrapped phase with integers directly, a two-step training process with the same network configuration is proposed. In the first step, the network (network I) is trained to label only four key features in the wrapped phase. In the second step, another network with same configuration (network II) is trained to label the wrapped phase segments. The advantages are that the dimension of the wrapped phase can be much larger from that of the training data, and the phase with serious Gaussian noise can be correctly unwrapped. We demonstrate the performance and key features of the neural network trained with the simulation data for the experimental data.Open access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

Failure Analysis of a New Irrigation Water Allocation Mode Based on Copula Approaches in the Zhanghe Irrigation District, China

The risk analysis of an irrigation water allocation strategy based on physical mechanisms is critically important in practice. Conventional risk analysis only considers the role of the channel system and ignores the factors related to on-farm ponds. This paper proposes a channel-pond joint water supply mode (CPJM) based on copula approaches. Two copulas, the Plackett copula and No.16 copula, are chosen and two types of analyses are carried out with the proposed mode: (1) a risk assessment of CPJM with joint probability and conditional probability; and (2) determination of the water supply strategy given the pond water supply frequency. With a case study of the second channel in the Zhanghe Irrigation District (ZID), Southern China, nine combinations of channel water supply frequency (CWSF) and pond water supply frequency (PWSF) are studied. The results reveal that the failure probabilities of the joint distribution and the conditional distribution of the CPJM are 0.02%–16.54% and 0.45%–33.08%, respectively, with corresponding return period of 42–5000 and 10–222 years. Nevertheless, a previous study has shown that the real probability is 33.3%, which means that the return period is equals to three years. Therefore, the objective failure evaluation of the irrigation water-use strategy is useful for water saving in this channel system. Moreover, the irrigation water allocation strategy can be determined and the failure charts relating the CWSF and PWSF can be obtained for a predetermined PWSF. Thus, the channel-pond joint water supply mode provides a more reasonable estimate of the irrigation water allocation strategy reliability

A case of non-O1/non-O139 Vibrio cholerae septicemia and meningitis in a neonate

A case of septicemia with meningitis due to non-O1/non-O139 Vibrio cholerae in a neonate is reported. The genotype and phenotype of the isolate were examined in relation to the major virulence genes. The isolate was shown to be non-toxin but cytotoxin-producing, distinguished from the dominant clone of non-O1/non-O139 V. cholerae by multilocus sequence typing

Additional file 4: Table S2. of Efficient TALEN-mediated myostatin gene editing in goats

Primers for PCR amplification of TALENs target regions. (DOC 29 kb

Additional file 1: Table S1. of Efficient TALEN-mediated myostatin gene editing in goats

TALEN target sequences. (DOC 35 kb