2 research outputs found
Generating Electrospray Ionization on Ballpoint Tips
In this study, we report a simple
and economical ballpoint electrospray
ionization mass spectrometry (BP-ESI-MS) technique. This combines
a small ballpoint tip with a syringe pump for the direct loading and
ionization of various samples in different phases (including solution,
semisolid, and solid) and allows for additional applications in surface
analysis. The tiny metal ball on the ballpoint tip exhibits a larger
surface for ionization than that of a conventional sharp tip end,
resulting in higher ionization efficiency and less sample consumption.
The adamant properties of the ballpoint tip allow sampling by simply
penetrating or scraping various surfaces, such as a fruit peel, paper,
or fabric. Complex samples, such as fine herbal powders and small
solid samples, could be stored in the hollow space in the ballpoint
socket and subsequently extracted online, which greatly facilitated
MS analysis with little to no sample preparation. Positive ion mode
was attempted, and various compounds, including amino acids, carbohydrates,
flavonoids, and alkaloids, were detected from different types of samples.
The results demonstrated that the special and excellent physical characteristics
of ballpoint tips allowed for fast and convenient sampling and ionization
for mass spectrometry analysis by the BP-ESI-MS method
Determination of Sulfonamides in Chicken Muscle by Pulsed Direct Current Electrospray Ionization Tandem Mass Spectrometry
A simple and rapid approach for the
simultaneous detection of trace
amounts of six sulfonamides in chicken muscle was developed using
pulsed direct current electrospray ionization tandem mass spectrometry
(pulsed-dc ESI-MS/MS). The pretreatment of chicken muscle samples
consisted of two steps: acetonitrile extraction and <i>n</i>-hexane delipidation. Sulfonamides do not need to be derivatized
or chromatographed prior to pulsed-dc ESI-MS/MS. The factors affecting
the performance of pulsed-dc ESI-MS/MS were studied. Under optimum
conditions, the quantitative performance of pulsed-dc ESI-MS/MS was
validated according to European Union Decision 2002/657/EC, and the
sensitivity of pulsed-dc ESI-MS/MS was 3 times higher than that of
ultrahigh-performance liquid chromatography-tandem mass spectrometry
(UPLC-MS/MS). The limits of detection obtained by pulsed-dc ESI-MS/MS
were in the range of 0.07–0.11 μg/kg. The proposed method
was simple, rapid, and sensitive, and was successfully used for quantitation
and rapid screening of sulfonamides in real chicken muscle samples