33 research outputs found
The presenting symptoms of the probable and possible sCJD patients.
1<p>including sleeping turbulence, depression, anxiety and stress etc.</p>2<p>when the dementia persists longer than one year progressively without other manifestations.</p
The geographic distribution of probable and possible sCJD cases based on the permanent residences.
<p>The numbers of probable and possible sCJD cases in each province were showed as X (X), respectively.</p
The frequencies of other four clinical manifestations except progressive dementia in 138 probable sCJD patients with two examinations.
<p>*compared with the data of 14-3-3 positive, <i>P</i> = 0.006.</p
The appearances of main clinical manifestations except progressive dementia in probable and possible sCJD patients.
<p>The appearances of main clinical manifestations except progressive dementia in probable and possible sCJD patients.</p
The frequencies of other four clinical manifestations except progressive dementia in probable and possible sCJD patients.
<p>The frequencies of other four clinical manifestations except progressive dementia in probable and possible sCJD patients.</p
Comparison of the results of 14-3-3 and EEG with the appearances of clinical manifestations in 138 probable sCJD patients with two examinations.
<p>*compared with the data of 14-3-3 positive, <i>P</i> = 0.0008.</p><p>**compared with the data of 14-3-3 positive, <i>P</i> = 0.0076.</p
Dynamic analysis of MAP2 and PrP<sup>Sc</sup> in the brain tissues of normal and 263K-infected hamsters during incubation period.
<p>A. Western blots. Same amounts of individual brain homogenate were loaded in 6% or 12% SDS-PAGE. Various specific immunoblots were marked on the left and the time of post-inoculation are showed as days (d) at the bottom. B. Quantitative analysis of each gray numerical value of MAP2a/2b, MAP2c, 2d and PrP<sup>Sc</sup> vs that of individual β-actin. The average relative gray value is calculated from three independent blots and presented as mean ± S.D.</p
Analyses of the MAP2 levels in SK-N-SH cells exposed to PrP106–126.
<p>A. SK-N-SH cells were treated with 200 µM of PrP106–126, scrambled peptide PrP106–126 (SCR) or DMSO for 6 h and 12 h. The treated cells were photographed with a light microscope (×20). B. Cell viability after exposed to different concentrations of PrP106–126 or SCR. The average data of each preparation was calculated based on three independent experiments and represented as mean ± S.D. C. Western blots of MAP2a/2b, MAP2c, 2d and β-actin in SK-N-SH cells after treated with 200 µM of PrP106–126, SCR or DMSO for 6 h and 12 h. D. Quantitative analyses of each gray numerical value of MAP2a/2b, MAP2c, 2d vs that of individual β-actin. The average relative gray value is calculated from three independent blots and presented as mean ± S.D. Statistical differences compared with controls are illustrated as P<0.05 and P<0.01.</p
Analyses of calpain levels in the brain tissues of 263K-infected hamsters.
<p>A. Western blots of calpain in the infected and normal hamsters. B. Quantitative analyses of the gray numerical values of calpain. The average gray values were calculated from four infected hamsters or or four normal after normalized with that of individual β-actin and presented as mean ± SD. Statistical difference is illustrated as P<0.01. C. Western blots of calpain and tubulin in the brain tissues of 263K-infected hamsters on 0, 20, 40, 60 and 80 dpi. D. Quantitative analyses of the gray numerical values of calpain and tubulin vs that of individual β-actin. The average relative gray value is calculated from three independent blots and presented as mean ± S.D.</p
Analyses of calpain levels in PrP106–126 treated SK-N-SH cells.
<p>A. Western blots of calpain in cells exposed to DMSO, PrP106–126 or SCR. B. Quantitative analyses of the gray numerical values of calpain. The average relative gray value is calculated from three independent blots and presented as mean ± S.D. Statistical differences are illustrated as P<0.01. C. Western blots of MAP2 in the cells treated with PrP106–126 alone and PrP106–126 plus calpain inhibitor ALLN. D. Quantitative analyses of the gray numerical values of MAP2a/2b, MAP2d and MAP2c. The average relative gray value is calculated from three independent blots and presented as mean ± S.D. Statistical differences are illustrated as P<0.01.</p