Study the Heavy Molecular States in Quark Model with Meson Exchange Interaction

Some charmonium-like resonances such as X(3872) can be interpreted as possible $D^{(*)}D^{(*)}$ molecular states. Within the quark model, we study the structure of such molecular states and the similar $B^{(*)}B^{(*)}$ molecular states by taking into account of the light meson exchange ($\pi$, $\eta$, $\rho$, $\omega$ and $\sigma$) between two light quarks from different mesons

Dynamical study of the possible molecular state X(3872) with the s-channel one gluon exchange interaction

The recently observed X(3872) resonance, which is difficult to be assigned a conventional $c\bar{c}$ charmonium state in the quark model, may be interpreted as a molecular state. Such a molecular state is a hidden flavor four quark state because of its charmonium-like quantum numbers. The s-channel one gluon exchange is an interaction which only acts in the hidden flavor multi-quark system. In this paper, we will study the X(3872) and other similiar hidden flavor molecular states in a quark model by taking into account of the s-channel one gluon exchange interaction

Investigation of radial force and hydraulic performance in a centrifugal pump with different guide vane outlet angle

In order to investigate the effect of the guide vane outlet angle on the performance of centrifugal pumps, a centrifugal pump with guide vanes was used as the research model and its specific speed is 165. Keep all the other geometry parameters of the pump as constants, the guide vane outlet angle was designed to be 28°, 20°, 15°,10°, 5° and 3° respectively. The whole flow field in the pump under different guide vane outlet angles was simulated by commercial code CFX and the simulation was unsteady. The simulation results were validated by experiment results. According to the simulations, the hydraulic performance, internal flow and radial force of the pump under different guide vane outlet angles were compared and analyzed in detail. The research results indicate that the head and efficiency of the pump are the best when the guide vane outlet angle is 10°. With the decrease of the blade outlet angle of guide vane, the length of flow channels in the guide vane become bigger and its width gets smaller, the uniformity of inner flow in the centrifugal pump gets better, and therefore the radial force on the impeller reduces. With the decrease of the guide vane blade outlet angle, the pulsation frequency of radial force does not change, but the pulsation amplitude of the radial force reduces obviously. The vector distribution of the unsteady radial force is symmetric around the origin and mainly lies in 5 regions, which is same as the blade number of impeller

Immune Landscape of Invasive Ductal Carcinoma Tumor Microenvironment Identifies a Prognostic and Immunotherapeutically Relevant Gene Signature

Background: Invasive ductal carcinoma (IDC) is a clinically and molecularly distinct disease. Tumor microenvironment (TME) immune phenotypes play crucial roles in predicting clinical outcomes and therapeutic efficacy. Method: In this study, we depict the immune landscape of IDC by using transcriptome profiling and clinical characteristics retrieved from The Cancer Genome Atlas (TCGA) data portal. Immune cell infiltration was evaluated via single-sample gene set enrichment (ssGSEA) analysis and systematically correlated with genomic characteristics and clinicopathological features of IDC patients. Furthermore, an immune signature was constructed using the least absolute shrinkage and selection operator (LASSO) Cox regression algorithm. A random forest algorithm was applied to identify the most important somatic gene mutations associated with the constructed immune signature. A nomogram that integrated clinicopathological features with the immune signature to predict survival probability was constructed by multivariate Cox regression. Results: The IDC were clustered into low immune infiltration, intermediate immune infiltration, and high immune infiltration by the immune landscape. The high infiltration group had a favorable survival probability compared with that of the low infiltration group. The low-risk score subtype identified by the immune signature was characterized by T cell-mediated immune activation. Additionally, activation of the interferon-α response, interferon-γ response, and TNF-α signaling via the NFκB pathway was observed in the low-risk score subtype, which indicated T cell activation and may be responsible for significantly favorable outcomes in IDC patients. A random forest algorithm identified the most important somatic gene mutations associated with the constructed immune signature. Furthermore, a nomogram that integrated clinicopathological features with the immune signature to predict survival probability was constructed, revealing that the immune signature was an independent prognostic biomarker. Finally, the relationship of VEGFA, PD1, PDL-1, and CTLA-4 expression with the immune infiltration landscape and the immune signature was analyzed to interpret the responses of IDC patients to immunotherapy. Conclusion: Taken together, we performed a comprehensive evaluation of the immune landscape of IDC and constructed an immune signature related to the immune landscape. This analysis of TME immune infiltration landscape has shed light on how IDC respond to immunotherapy and may guide the development of novel drug combination strategies

Local melting to design strong and plastically deformable bulk metallic glass composites

Recently, CuZr-based bulk metallic glass (BMG) composites reinforced by the TRIP (transformation-induced plasticity) effect have been explored in attempt to accomplish an optimal of trade-off between strength and ductility. However, the design of such BMG composites with advanced mechanical properties still remains a big challenge for materials engineering. In this work, we proposed a technique of instantaneously and locally arc-melting BMG plate to artificially induce the precipitation of B2 crystals in the glassy matrix and then to tune mechanical properties. Through adjusting local melting process parameters (i.e. input powers, local melting positions, and distances between the electrode and amorphous plate), the size, volume fraction, and distribution of B2 crystals were well tailored and the corresponding formation mechanism was clearly clarified. The resultant BMG composites exhibit large compressive plasticity and high strength together with obvious work-hardening ability. This compelling approach could be of great significance for the steady development of metastable CuZr-based alloys with excellent mechanical properties

2-Anilino-3-(2-hy­droxy­phen­yl)quinazolin-4(3H)-one–triphenyl­phosphine oxide (1/1)

In the title compound, C20H15N3O2·C18H15OP, the pyrimidinone heterocycle and the fused phenyl ring are inclined at 1.92 (7)°. Only the hy­droxy group is involved in hydrogen bonding, whereas the amino group is shielded from potential acceptors