1 research outputs found
Dysiarenone, a Dimeric C<sub>21</sub> Meroterpenoid with Inhibition of COX‑2 Expression from the Marine Sponge <i>Dysidea arenaria</i>
Dysiarenone
(<b>1</b>), a dimeric C<sub>21</sub> meroterpenoid
featuring an unprecedented 2-oxaspiroÂ[bicyclo[3.3.1]Ânonane-9,1′-cyclopentane]
carbon skeleton, was isolated from the marine sponge <i>Dysidea
arenaria</i>. The structure of <b>1</b> was determined
by HRMS and NMR spectroscopic analyses coupled with ECD calculations.
Dysiarenone showed inhibitory activities against COX-2 expression
and the production of prostaglandin E<sub>2</sub> with an IC<sub>50</sub> value of 6.4 μM in LPS-stimulated RAW264.7 macrophages