From Stem to Roots: tissue engineering in Endodontics

The vitality of dentin-pulp complex is fundamental to the life of tooth and is a priority for targeting clinical management strategies. Loss of the tooth, jawbone or both, due to periodontal disease, dental caries, trauma or some genetic disorders, affects not only basic mouth functions but aesthetic appearance and quality of life. One novel approach to restore tooth structure is based on biology: regenerative endodontic procedure by application of tissue engineering. Regenerative endodontics is an exciting new concept that seeks to apply the advances in tissue engineering to the regeneration of the pulp-dentin complex. The basic logic behind this approach is that patient-specific tissue-derived cell populations can be used to functionally replace integral tooth tissues. The development of such 'test tube teeth' requires precise regulation of the regenerative events in order to achieve proper tooth size and shape, as well as the development of new technologies to facilitate these processes. This article provides an extensive review of literature on the concept of tissue engineering and its application in endodontics, providing an insight into the new developmental approaches on the horizon

Solutions for Financial Inclusion: Serving Rural Women

This document presents a CaseStudy for solutions for financial inclusion. Using Uganda as a CaseStudy, Women's World Banking set out to better understand the needs of rural women and to use the research and lessons learned there to make recommendations on the design and delivery of microfinance products within Uganda and throughout sub-Saharan Africa. The research highlights the specific gender-based social, cultural and legal barriers that rural women face in accessing and using financial services and examines operational challenges to effectively serving this market

"Nanodentistry": exploring the beauty of miniature

Feynman's early vision in 1959 gave birth to the concept of nanotechnology. He saw it as an unavoidable development in the progress of science and said that there is plenty of room at the bottom. Since then, nanotechnology has been part of mainstream scientific theory with. potential medical and dental applications. Numerous theoretical predictions have been made based on the potential applications of nanotechnology in dentistry, with varying levels of optimism. While a few layers of nanotechnologic capability have become a reality for oral health in the last decade, many of these applications are still in their puerile stage .The most substantial contribution of nanotechnology to dentistry till date, is the more enhanced restoration of tooth structure with nanocomposites. The field of nanotechnology has tremendous potential, which if harnessed efficiently, can bring out significant benefits to the human society such as improved health, better use of natural resources, and reduced environmental pollution. The future holds in store an era of dentistry in which every procedure will be performed using equipments and devices based on nanotechnology. This article reviews the current status and the potential clinical applications of nanotechnology in dentistry

Study of prognostic importance of hs-CRP levels in acute stroke patients coming to Theerthanker Mahaveer Medical College, Moradabad, Uttar Pradesh, India

Background: Stroke has been found to be the fourth most fatal cause of death around the globe. Decreased activity and physical work are the major causes of increased incidences of stoke worldwide. It has also been studied that elevated levels of high-sensitivity C-reactive protein (hs-CRP) have been related to vascular inflammation whereas CRP is an important biomarker of systemic inflammation. Aim of this study to measure serum high-sensitivity C-reactive protein (hs-CRP) levels in the patients presenting with stroke, and evaluating its correlation as a prognostic marker in stroke patients.Methods: It was an observational prospective hospital-based case study carried out at Teerthanker Mahaveer Medical College and Research Centre, a tertiary care hospital situated in Moradabad, India for 5 months period from 1st November 2018 to 31st March 2019. 100 patients of new-onset stroke were included in the study.Results: According to the Scandinavian score, the majority of the patients who had ischemic stroke depicted a score range from 2-8. On the other hand, the majority the patients with hemorrhagic score had a Scandinavian score >14. The mean hs-CRP, when observed between different ranges of the Scandinavian score, showed that in 2-8 range the mean hs-CRP was 31.49±15.00, the mean hs-CRP for 9-14 range was 7.99±6.32 and the mean hs-CRP for >14 range was 7.10±0.32.Conclusions: It can be identified that levels of hs-CRP can be used as a marker to predict the long term prognosis of patients with stroke. In addition to this, it can also be identified that patients with higher levels of hs-CRP have lower Scandinavian score and the patients with lower hs-CRP levels have a higher Scandinavian score. Also, the results show that patients with ischaemic stroke have higher hs-CRP levels as compared to hemorrhagic stroke

Study various clinical manifestations and biochemical parameter for liver dysfunction in association with Plasmodium vivax malaria

Background: Malaria is a parasitic disease which is majorly caused by the bite of an infected Anopheles mosquito. It has been estimated that the most common type of malaria affecting the human race is known as Plasmodium vivax. Human malaria is a global burden with 3.4 billion people at risk over 91 endemic countries. According to the WHO, the involvement of liver dysfunction in Plasmodium vivax malaria is not an uncommon phenomenon. Aim of the research was to study various clinical manifestations and biochemical parameter for liver dysfunction in association with Plasmodium vivax malaria.Methods: It was an observational study carried out at Teerthanker Mahaveer Medical College and Research Centre, a tertiary care hospital situated in Moradabad for a period of 1 year (March 2017-Feb 2018). Total of 200 patients aged above 15 years, with either sex were part of it. All the patients having mixed malaria with dengue, pregnant women and the patients who did not give written consent for being a part of the study were excluded from the study. A detailed clinical examination was done, including all the hematological and biochemical examinations.Results: The results depicted that the number of male patients was 95, and the number of female patients was 105. The majority of the patients belonged to 15-30 years of age group. The major clinical features of the patients suffering from P. Vivax were fever and jaundice. The number of patients with serum bilirubin >3 mg/dl was 55.Conclusions: In light of the above results, it was evident that Plasmodium vivax has the capability of producing jaundice, hepatic dysfunction and anemia. The doctors must be very vigilant while treating the patients with Plasmodium vivax for any symptoms of jaundice as they are often misunderstood as hepatitis

Fluorescence signalling of the transition metal ions: design strategy based on the choice of the fluorophore component

Transition metal ions are notorious for their fluorescence quenching abilities. In this paper, we discuss the design strategies for the development of efficientoff-on fluorescence signalling systems for the transition metal ions. It is shown that even simplefluorophore-spacer-receptor systems can display excellentoff-on fluorescence signalling towards the quenching metal ions when the fluorophore component is chosen judiciously