A Pyramid Scheme for Particle Physics

We introduce a new model, the Pyramid Scheme, of direct mediation of SUSY breaking, which is compatible with the idea of Cosmological SUSY Breaking (CSB). It uses the trinification scheme of grand unification and avoids problems with Landau poles in standard model gauge couplings. It also avoids problems, which have recently come to light, associated with rapid stellar cooling due to emission of the pseudo Nambu-Goldstone Boson (PNGB) of spontaneously broken hidden sector baryon number. With a certain pattern of R-symmetry breaking masses, a pattern more or less required by CSB, the Pyramid Scheme leads to a dark matter candidate that decays predominantly into leptons, with cross sections compatible with a variety of recent observations. The dark matter particle is not a thermal WIMP but a particle with new strong interactions, produced in the late decay of some other scalar, perhaps the superpartner of the QCD axion, with a reheat temperature in the TeV range. This is compatible with a variety of scenarios for baryogenesis, including some novel ones which exploit specific features of the Pyramid Scheme.Comment: JHEP Latex, 32 pages, 1 figur

Bimetric Gravity Theory, Varying Speed of Light and the Dimming of Supernovae

In the bimetric scalar-tensor gravitational theory there are two frames associated with the two metrics {\hat g}_{\mu\nu} and g_{\mu\nu}, which are linked by the gradients of a scalar field \phi. The choice of a comoving frame for the metric {\hat g}_{\mu\nu} or g_{\mu\nu} has fundamental consequences for local observers in either metric spacetimes, while maintaining diffeomorphism invariance. When the metric g_{\mu\nu} is chosen to be associated with comoving coordinates, then the speed of light varies in the frame with the metric {\hat g}_{\mu\nu}. Observers in this frame see the dimming of supernovae because of the increase of the luminosity distance versus red shift, due to an increasing speed of light in the early universe. Moreover, in this frame the scalar field \phi describes a dark energy component in the Friedmann equation for the cosmic scale without acceleration. If we choose {\hat g}_{\mu\nu} to be associated with comoving coordinates, then an observer in the g_{\mu\nu} metric frame will observe the universe to be accelerating and the supernovae will appear to be farther away. The theory predicts that the gravitational constant G can vary in spacetime, while the fine-structure constant \alpha=e^2/\hbar c does not vary. The problem of cosmological horizons as viewed in the two frames is discussed.Comment: 22 pages, Latex file. No figures. Corrected typos. Added reference. Further references added. Further corrections. To be published in Int. J. Mod. Phys. D, 200

Model validation for a noninvasive arterial stenosis detection problem

Copyright @ 2013 American Institute of Mathematical SciencesA current thrust in medical research is the development of a non-invasive method for detection, localization, and characterization of an arterial stenosis (a blockage or partial blockage in an artery). A method has been proposed to detect shear waves in the chest cavity which have been generated by disturbances in the blood flow resulting from a stenosis. In order to develop this methodology further, we use both one-dimensional pressure and shear wave experimental data from novel acoustic phantoms to validate corresponding viscoelastic mathematical models, which were developed in a concept paper [8] and refined herein. We estimate model parameters which give a good fit (in a sense to be precisely defined) to the experimental data, and use asymptotic error theory to provide confidence intervals for parameter estimates. Finally, since a robust error model is necessary for accurate parameter estimates and confidence analysis, we include a comparison of absolute and relative models for measurement error.The National Institute of Allergy and Infectious Diseases, the Air Force Office of Scientific Research, the Deopartment of Education and the Engineering and Physical Sciences Research Council (EPSRC)

Nonsingular Black Hole Evaporation and ``Stable'' Remnants

We examine the evaporation of two--dimensional black holes, the classical space--times of which are extended geometries, like for example the two--dimensional section of the extremal Reissner--Nordstrom black hole. We find that the evaporation in two particular models proceeds to a stable end--point. This should represent the generic behavior of a certain class of two--dimensional dilaton--gravity models. There are two distinct regimes depending on whether the back--reaction is weak or strong in a certain sense. When the back--reaction is weak, evaporation proceeds via an adiabatic evolution, whereas for strong back--reaction, the decay proceeds in a somewhat surprising manner. Although information loss is inevitable in these models at the semi--classical level, it is rather benign, in that the information is stored in another asymptotic region.Comment: 23 pages, 6 figures, harvmac and epsf, RU-93-12, PUPT-1399, NSF-ITP-93-5

Information Content in Data Sets for a Nucleated-Polymerization Model

We illustrate the use of tools (asymptotic theories of standard error quantification using appropriate statistical models, bootstrapping, model comparison techniques) in addition to sensitivity that may be employed to determine the information content in data sets. We do this in the context of recent models [23] for nucleated polymerization in proteins, about which very little is known regarding the underlying mechanisms; thus the methodology we develop here may be of great help to experimentalists

Nonsingular Lagrangians for Two Dimensional Black Holes

We introduce a large class of modifications of the standard lagrangian for two dimensional dilaton gravity, whose general solutions are nonsingular black holes. A subclass of these lagrangians have extremal solutions which are nonsingular analogues of the extremal Reissner-Nordstrom spacetime. It is possible that quantum deformations of these extremal solutions are the endpoint of Hawking evaporation when the models are coupled to matter, and that the resulting evolution may be studied entirely within the framework of the semiclassical approximation. Numerical work to verify this conjecture is in progress. We point out however that the solutions with non-negative mass always contain Cauchy horizons, and may be sensitive to small perturbations.Comment: 27 pages, three figures, RU-92-61. (Replaced version contains some corrections to incorrect equations. The zero temperature extremal geometry (the conjectured end-point of the Hawking evaporation) is not as stated in the previous version, but rather is a nonsingular analogue of the zero temperature $M^2 = Q^2$ Reissner-Nordstrom space-time.

Are Group Psychotherapeutic Treatments Effective for Patients with Schizophrenia? A Systematic Review and Meta-Analysis

&lt;b&gt;&lt;i&gt;Background:&lt;/i&gt;&lt;/b&gt; Different psychotherapeutic treatments for schizophrenia are delivered in groups. However, little is known about the effectiveness of these group therapies for people with schizophrenia across different treatments with varying therapeutic orientations. This review aimed to (1) estimate the effect of different group psychotherapeutic treatments for schizophrenia and (2) explore whether any overall ‘group effect' is moderated by treatment intensity, diagnostic homogeneity and therapeutic orientation. &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; A systematic search of randomised controlled trials exploring the effectiveness of group psychotherapeutic treatments for people with schizophrenia was conducted. Random-effect meta-analyses on endpoint symptom scores compared group psychotherapeutic treatments with treatment as usual and active sham groups. Findings on social functioning were described narratively, and meta-regression analyses on group characteristics were carried out. &lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; Thirty-four eligible trials were included. A weak-to-moderate significant between-group difference in favour of group psychotherapeutic treatments was found for negative symptom scores (standard mean difference = -0.37, 95% confidence interval -0.60, -0.14; p &lt; 0.01, I&lt;sup&gt;2&lt;/sup&gt; = 59.8%) only when compared to treatment as usual and not to active sham groups. Improved social functioning was reported as a treatment outcome in the majority of studies compared to treatment as usual. The ‘group effect' on negative symptoms was positively related to ‘treatment intensity' (β = 0.32, standard error = 0.121; p &lt; 0.05). &lt;b&gt;&lt;i&gt;Conclusion:&lt;/i&gt;&lt;/b&gt; Group psychotherapeutic treatments can improve negative symptoms and social functioning deficits in the treatment of schizophrenia. The effect occurs across different treatments and appears to be non-specific. Future research should identify the underlying mechanisms for the positive effect of participating in groups and explore how they can be maximised to increase the therapeutic benefit.</jats:p

Quantum Moduli Spaces of N=1N=1 String Theories

Generically, string models with $N=1$ supersymmetry are not expected to have moduli beyond perturbation theory; stringy non-perturbative effects as well as low energy field-theoretic phenomena such as gluino condensation will lift any flat directions. In this note, we describe models where some subspace of the moduli space survives non-perturbatively. Discrete $R$ symmetries forbid any inherently stringy effects, and dynamical considerations control the field-theoretic effects. The surviving subspace is a space of high symmetry; the system is attracted to this subspace by a potential which we compute. Models of this type may be useful for considerations of duality and raise troubling cosmological questions about string theory. Our considerations also suggest a mechanism for fixing the expectation value of the dilaton.Comment: 26 pages; uses harvmac. Footnote re fixing dilaton adde

Vestibular heading discrimination and sensitivity to linear acceleration in head and world coordinates

Effective navigation and locomotion depend critically on an observer\u27s ability to judge direction of linear self-motion, i.e., heading. The vestibular cue to heading is the direction of inertial acceleration that accompanies transient linear movements. This cue is transduced by the otolith organs. The otoliths also respond to gravitational acceleration, so vestibular heading discrimination could depend on (1) the direction of movement in head coordinates (i.e., relative to the otoliths), (2) the direction of movement in world coordinates (i.e., relative to gravity), or (3) body orientation (i.e., the direction of gravity relative to the otoliths). To quantify these effects, we measured vestibular and visual discrimination of heading along azimuth and elevation dimensions with observers oriented both upright and side-down relative to gravity. We compared vestibular heading thresholds with corresponding measurements of sensitivity to linear motion along lateral and vertical axes of the head (coarse direction discrimination and amplitude discrimination). Neither heading nor coarse direction thresholds depended on movement direction in world coordinates, demonstrating that the nervous system compensates for gravity. Instead, they depended similarly on movement direction in head coordinates (better performance in the horizontal plane) and on body orientation (better performance in the upright orientation). Heading thresholds were correlated with, but significantly larger than, predictions based on sensitivity in the coarse discrimination task. Simulations of a neuron/anti-neuron pair with idealized cosine-tuning properties show that heading thresholds larger than those predicted from coarse direction discrimination could be accounted for by an amplitude-response nonlinearity in the neural representation of inertial motion

Comments on information loss and remnants

The information loss and remnant proposals for resolving the black hole information paradox are reconsidered. It is argued that in typical cases information loss implies energy loss, and thus can be thought of in terms of coupling to a spectrum of ``fictitious'' remnants. This suggests proposals for information loss that do not imply planckian energy fluctuations in the low energy world. However, if consistency of gravity prevents energy non-conservation, these remnants must then be considered to be real. In either case, the catastrophe corresponding to infinite pair production remains a potential problem. Using Reissner-Nordstrom black holes as a paradigm for a theory of remnants, it is argued that couplings in such a theory may give finite production despite an infinite spectrum. Evidence for this is found in analyzing the instanton for Schwinger production; fluctuations from the infinite number of states lead to a divergent stress tensor, spoiling the instanton calculation. Therefore naive arguements for infinite production fail.Comment: 30 pages (harvmac l mode) UCSBTH-93-35 (minor reference and typo corrections