A Note on D-brane - Anti-D-brane Interactions in Plane Wave Backgrounds

We study aspects of the interaction between a D-brane and an anti-D-brane in the maximally supersymmetric plane wave background of type IIB superstring theory, which is equipped with a mass parameter mu. An early such study in flat spacetime (mu=0) served to sharpen intuition about D-brane interactions, showing in particular the key role of the ``stringy halo'' that surrounds a D-brane. The halo marks the edge of the region within which tachyon condensation occurs, opening a gateway to new non-trivial vacua of the theory. It seems pertinent to study the fate of the halo for non--zero mu. We focus on the simplest cases of a Lorentzian brane with p=1 and an Euclidean brane with p=-1, the D--instanton. For the Lorentzian brane, we observe that the halo is unaffected by the presence of non--zero mu. This most likely extends to other (Lorentzian) p. For the Euclidean brane, we find that the halo is affected by non-zero mu. As this is related to subtleties in defining the exchange amplitude between Euclidean branes in the open string sector, we expect this to extend to all Euclidean branes in this background.Comment: 14 pages, LaTeX, 2 eps figures. v2: a reference and some clarifying remarks added; v3: Considerably revised version; halo unaffected by plane wave background for Lorentzian branes, but Euclidean branes' halo is modifie

The genetic architecture of type 2 diabetes

The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies have identified scores of common variants associated with type 2 diabetes, but in aggregate, these explain only a fraction of heritability. To test the hypothesis that lower-frequency variants explain much of the remainder, the GoT2D and T2D-GENES consortia performed whole genome sequencing in 2,657 Europeans with and without diabetes, and exome sequencing in a total of 12,940 subjects from five ancestral groups. To increase statistical power, we expanded sample size via genotyping and imputation in a further 111,548 subjects. Variants associated with type 2 diabetes after sequencing were overwhelmingly common and most fell within regions previously identified by genome-wide association studies. Comprehensive enumeration of sequence variation is necessary to identify functional alleles that provide important clues to disease pathophysiology, but large-scale sequencing does not support a major role for lower-frequency variants in predisposition to type 2 diabetes

Mapping and characterization of structural variation in 17,795 human genomes

A key goal of whole-genome sequencing for studies of human genetics is to interrogate all forms of variation, including single-nucleotide variants, small insertion or deletion (indel) variants and structural variants. However, tools and resources for the study of structural variants have lagged behind those for smaller variants. Here we used a scalable pipeline1 to map and characterize structural variants in 17,795 deeply sequenced human genomes. We publicly release site-frequency data to create the largest, to our knowledge, whole-genome-sequencing-based structural variant resource so far. On average, individuals carry 2.9 rare structural variants that alter coding regions; these variants affect the dosage or structure of 4.2 genes and account for 4.0–11.2% of rare high-impact coding alleles. Using a computational model, we estimate that structural variants account for 17.2% of rare alleles genome-wide, with predicted deleterious effects that are equivalent to loss-of-function coding alleles; approximately 90% of such structural variants are noncoding deletions (mean 19.1 per genome). We report 158,991 ultra-rare structural variants and show that 2% of individuals carry ultra-rare megabase-scale structural variants, nearly half of which are balanced or complex rearrangements. Finally, we infer the dosage sensitivity of genes and noncoding elements, and reveal trends that relate to element class and conservation. This work will help to guide the analysis and interpretation of structural variants in the era of whole-genome sequencing

The tangled web we weave: human mediated spread of nematodes via trade networks

Quarantine and hygiene are major measures for preventing damage from plant-parasitic nematodes, but there is little information on nematode spread, especially related to rapidly increasing trade associated with globalization. To investigate nematode movement associated with traded plant material, nematodes were sampled from markets of different sizes and types in several countries, together with the origins and destinations of the produce and volumes traded. Nematodes were found consistently on various crops and associated soil. All trophic groups were represented. Markets differed in the distances produce travelled to get there, with some trading mostly local material, others trading mostly material from distant places, and others with a mix of the two. These patterns of movement can be analysed using network models and mapping software to suggest the speed, distance and amount of nematode spread using these pathways. This information will enhance biosecurity and quarantine through better targeting of surveillance and preventative measures