218 research outputs found
L-Arginine promotes gut hormone release and reduces food intake in rodents
Aims: To investigate the anorectic effect of Lâarginine (LâArg) in rodents.
Methods: We investigated the effects of LâArg on food intake, and the role of the anorectic gut hormones glucagonâlike peptideâ1 (GLPâ1) and peptide YY (PYY), the Gâproteinâcoupled receptor family C group 6 member A (GPRC6A) and the vagus nerve in mediating these effects in rodents.
Results: Oral gavage of LâArg reduced food intake in rodents, and chronically reduced cumulative food intake in dietâinduced obese mice. Lack of the GPRC6A in mice and subdiaphragmatic vagal deafferentation in rats did not influence these anorectic effects. LâArg stimulated GLPâ1 and PYY release in vitro and in vivo. Pharmacological blockade of GLPâ1 and PYY receptors did not influence the anorectic effect of LâArg. LâArgâmediated PYY release modulated net ion transport across the gut mucosa. Intracerebroventricular (i.c.v.) and intraperitoneal (i.p.) administration of LâArg suppressed food intake in rats.
Conclusions: LâArg reduced food intake and stimulated gut hormone release in rodents. The anorectic effect of LâArg is unlikely to be mediated by GLPâ1 and PYY, does not require GPRC6A signalling and is not mediated via the vagus. I.c.v. and i.p. administration of LâArg suppressed food intake in rats, suggesting that LâArg may act on the brain to influence food intake. Further work is required to determine the mechanisms by which LâArg suppresses food intake and its utility in the treatment of obesity
The Constraints of Conformal Symmetry on RG Flows
If the coupling constants in QFT are promoted to functions of space-time, the
dependence of the path integral on these couplings is highly constrained by
conformal symmetry. We begin the present note by showing that this idea leads
to a new proof of Zamolodchikov's theorem. We then review how this simple
observation also leads to a derivation of the a-theorem. We exemplify the
general procedure in some interacting theories in four space-time dimensions.
We concentrate on Banks-Zaks and weakly relevant flows, which can be controlled
by ordinary and conformal perturbation theories, respectively. We compute
explicitly the dependence of the path integral on the coupling constants and
extract the change in the a-anomaly (this agrees with more conventional
computations of the same quantity). We also discuss some general properties of
the sum rule found in arXiv:1107.3987 and study it in several examples.Comment: 25 pages, 5 figure
Holographic non-perturbative corrections to gauge couplings
We give a direct microscopic derivation of the F-theory background that
corresponds to four D7 branes of type I' theory by taking into account the
D-instanton contributions to the emission of the axio-dilaton field in the
directions transverse to the D7's. The couplings of the axio-dilaton to the
D-instanton moduli modify its classical source terms which are shown to be
proportional to the elements of the D7 brane chiral ring. Solving the bulk
field equations with the non-perturbatively corrected sources yields the full
F-theory background. This solution represents the gravitational dual of the
four-dimensional theory living on a probe D3 brane of type I', namely of the
N=2, Sp(1) SYM theory with Nf=4. Our results provide an explicit microscopic
derivation of the non-perturbative gravitational dual of this theory. They also
explain the recent observation that the exact coupling for this theory can be
entirely reconstructed from its perturbative part plus the knowledge of the
chiral ring on the D7 branes supporting its flavor degrees of freedom.Comment: Latex, 39 pages, 6 figure
D-brane potentials in the warped resolved conifold and natural inflation
In this paper we obtain a model of Natural Inflation from string theory with
a Planckian decay constant. We investigate D-brane dynamics in the background
of the warped resolved conifold (WRC) throat approximation of Type IIB string
compactifications on Calabi-Yau manifolds. When we glue the throat to a compact
bulk Calabi-Yau, we generate a D-brane potential which is a solution to the
Laplace equation on the resolved conifold. We can exactly solve this equation,
including dependence on the angular coordinates. The solutions are valid down
to the tip of the resolved conifold, which is not the case for the more
commonly used deformed conifold. This allows us to exploit the effect of the
warping, which is strongest at the tip. We inflate near the tip using an
angular coordinate of a D5-brane in the WRC which has a discrete shift
symmetry, and feels a cosine potential, giving us a model of Natural Inflation,
from which it is possible to get a Planckian decay constant whilst maintaining
control over the backreaction. This is because the decay constant for a wrapped
brane contains powers of the warp factor, and so can be made large, while the
wrapping parameter can be kept small enough so that backreaction is under
control.Comment: 41 pages, 3 appendices, 1 figure, PDFLaTex; various clarifications
added along with a new appendix on b-axions and wrapped D5 branes;version
matches the one published in JHE
Stable Non-Supersymmetric Throats in String Theory
We construct a large class of non-supersymmetric AdS-like throat geometries
in string theory by taking non-supersymmetric orbifolds of supersymmetric
backgrounds. The scale of SUSY breaking is the AdS radius, and the dual field
theory has explicitly broken supersymmetry. The large hierarchy of energy
scales in these geometries is stable. We establish this by showing that the
dual gauge theories do not have any relevant operators which are singlets under
the global symmetries. When the geometries are embedded in a compact internal
space, a large enough discrete subgroup of the global symmetries can still
survive to prevent any singlet relevant operators from arising. We illustrate
this by embedding one case in a non-supersymmetric orbifold of a Calabi-Yau
manifold. These examples can serve as a starting point for obtaining
Randall-Sundrum models in string theory, and more generally for constructing
composite Higgs or technicolor-like models where strongly coupled dynamics
leads to the breaking of electro-weak symmetry. Towards the end of the paper,
we briefly discuss how bulk gauge fields can be incorporated by introducing
D7-branes in the bulk, and also show how the strongly coupled dynamics can lead
to an emergent weakly coupled gauge theory in the IR with matter fields
including scalars.Comment: 28 pages,2 figure
Scalar Three-point Functions in a CDL Background
Motivated by the FRW-CFT proposal by Freivogel, Sekino, Susskind and Yeh, we
compute the three-point function of a scalar field in a Coleman-De Luccia
instanton background. We first compute the three-point function of the scalar
field making only very mild assumptions about the scalar potential and the
instanton background. We obtain the three-point function for points in the FRW
patch of the CDL instanton and take two interesting limits; the limit where the
three points are near the boundary of the hyperbolic slices of the FRW patch,
and the limit where the three points lie on the past lightcone of the FRW
patch. We expand the past lightcone three-point function in spherical
harmonics. We show that the near boundary limit expansion of the three-point
function of a massless scalar field exhibits conformal structure compatible
with FRW-CFT when the FRW patch is flat. We also compute the three-point
function when the scalar is massive, and explain the obstacles to generalizing
the conjectured field-operator correspondence of massless fields to massive
fields.Comment: 42 pages + appendices, 10 figures; v2, v3: minor correction
A de Sitter Hoedown
Rotating black holes in de Sitter space are known to have interesting limits
where the temperatures of the black hole and cosmological horizon are equal. We
give a complete description of the thermal phase structure of all allowed
rotating black hole configurations. Only one configuration, the rotating Nariai
limit, has the black hole and cosmological horizons both in thermal and
rotational equilibrium, in that both the temperatures and angular velocities of
the two horizons coincide. The thermal evolution of the spacetime is shown to
lead to the pure de Sitter spacetime, which is the most entropic configuration.
We then provide a comprehensive study of the wave equation for a massless
scalar in the rotating Nariai geometry. The absorption cross section at the
black hole horizon is computed and a condition is found for when the scattering
becomes superradiant. The boundary-to-boundary correlators at finite
temperature are computed at future infinity. The quasinormal modes are obtained
in explicit form. Finally, we obtain an expression for the expectation value of
the number of particles produced at future infinity starting from a vacuum
state with no incoming particles at past infinity. Some of our results are used
to provide further evidence for a recent holographic proposal between the
rotating Nariai geometry and a two-dimensional conformal field theory.Comment: 35 + 1 pages, 9 figures; v3: typos correcte
Phases of one dimensional large N gauge theory in a 1/D expansion
We consider large N Yang Mills theory with D adjoint scalar fields in d
dimensions for d=0 or 1. We show the existence of a non-trivial saddle point of
the functional integral at large D which is characterized by a mass gap for the
adjoint scalars. We integrate out the adjoint scalars in a 1/D expansion around
the saddle point. In case of one dimension which is regarded as a circle, this
procedure leads to an effective action for the Wilson line. We find an analogue
of the confinement/deconfinement transition which consists of a second order
phase transition from a uniform to a non-uniform eigenvalue distribution of the
Wilson line, closely followed by a Gross-Witten-Wadia transition where a gap
develops in the eigenvalue distribution. The phase transition can be regarded
as a continuation of a Gregory-Laflamme transition. Our methods involve large
values of the dimensionless 'tHooft coupling. The analysis in this paper is
quantitatively supported by earlier numerical work for D=9.Comment: 27 pages + 21 pages of Appendix; 8 figures, v2:some comments are
added in sec.4.3, minor corrections, one reference added, v3: minor
corrections, one reference added, version to be published in JHE
On the dynamical generation of the Maxwell term and scale invariance
Gauge theories with no Maxwell term are investigated in various setups. The
dynamical generation of the Maxwell term is correlated to the scale invariance
properties of the system. This is discussed mainly in the cases where the gauge
coupling carries dimensions. The term is generated when the theory contains a
scale explicitly, when it is asymptotically free and in particular also when
the scale invariance is spontaneously broken. The terms are not generated when
the scale invariance is maintained. Examples studied include the large
limit of the model in dimensions, a 3D gauged
vector model and its supersymmetric extension. In the latter case the
generation of the Maxwell term at a fixed point is explored. The phase
structure of the case is investigated in the presence of a Chern-Simons
term as well. In the supersymmetric model the emergence of the Maxwell
term is accompanied by the dynamical generation of the Chern-Simons term and
its multiplet and dynamical breaking of the parity symmetry. In some of the
phases long range forces emerge which may result in logarithmic confinement.
These include a dilaton exchange which plays a role also in the case when the
theory has no gauge symmetry. Gauged Lagrangian realizations of the 2D coset
models do not lead to emergent Maxwell terms. We discuss a case where the gauge
symmetry is anomalous.Comment: 38 pages, 4 figures; v2 slightly improved, typos fixed, references
added, published versio
Baryonic Popcorn
In the large N limit cold dense nuclear matter must be in a lattice phase.
This applies also to holographic models of hadron physics. In a class of such
models, like the generalized Sakai-Sugimoto model, baryons take the form of
instantons of the effective flavor gauge theory that resides on probe flavor
branes. In this paper we study the phase structure of baryonic crystals by
analyzing discrete periodic configurations of such instantons. We find that
instanton configurations exhibit a series of "popcorn" transitions upon
increasing the density. Through these transitions normal (3D) lattices expand
into the transverse dimension, eventually becoming a higher dimensional (4D)
multi-layer lattice at large densities.
We consider 3D lattices of zero size instantons as well as 1D periodic chains
of finite size instantons, which serve as toy models of the full holographic
systems. In particular, for the finite-size case we determine solutions of the
corresponding ADHM equations for both a straight chain and for a 2D zigzag
configuration where instantons pop up into the holographic dimension. At low
density the system takes the form of an "abelian anti-ferromagnetic" straight
periodic chain. Above a critical density there is a second order phase
transition into a zigzag structure. An even higher density yields a rich phase
space characterized by the formation of multi-layer zigzag structures. The
finite size of the lattices in the transverse dimension is a signal of an
emerging Fermi sea of quarks. We thus propose that the popcorn transitions
indicate the onset of the "quarkyonic" phase of the cold dense nuclear matter.Comment: v3, 80 pages, 18 figures, footnotes 5 and 7 added, version to appear
in the JHE
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