A comparison study on the anti-leech effects of onion (<em>Allium cepa L</em>) and ginger (<em>Zingiber officinale</em>) with levamisole and triclabendazole

Introduction: Leech may indwell in mucosa of the pharynx, tonsil, esophagus, nose, nasopharyngeal and rarely in larynx of hosts, however, the effective drugs against this parasite is scarce. This study was aimed to evaluate and compare the anti-leech effect of methanolic extract of onion (Allium cepa L) and ginger (Zingiber officinale) with levamisole and triclabendazole. Materials and Methods: In this study, 60 leeches (Limnatis nilotica) were collected from south of Ilam. The anti-leech effect of methanolic extract of onion and ginger in comparison with levamisole and triclabendazole drugs (positive controls) were evaluated. Distilled water was used as negative control. Paralysis and death of leeches were recorded in 720 minutes. Results: Lethal effect of methanolic extract of ginger against Limnatis nilotica was equal to levamisole and more than triclabendazole and methanolic extract of onion. Conclusion: Ginger equal to levamisole has anti-leech activity and its methanolic extract might be used against Limnatis nilotica.</p

Evaluating the Anti-Leech Effects of Methanolic Extracts of Peganum harmala L. and Olea europaea L. on Limnatis nilotica. World&apos;s Vet

ABSTRACT Leeches had several complications such as pain, itching, inflammation, severe anemia, short-term bleeding, hypersensitivity, and anaphylactic reactions in their hosts. Harmal Peganum harmala L. is used as an analgesic and anti-inflammatory agent and it has antibacterial activity. Olive Olea europaea L. has antibacterial, anti-viral, hypoglycemic and the relaxation of blood vessels properties. Antioxidant properties of olive also had been reported. This study was carried out to detect the effects of methanolic extracts of P. harmala L. and O. europaea L. on L. nilotica immature form. In 2011, 55 immature leeches collected from the southern area of Ilam province were prepared. The methanolic extract of O. europaea L and P. harmala L. were compared with levamisole as the control drug. Distilled water was evaluated as the placebo group which investigated L. nilotica using anti-leech assay. Then extract and drugs were added and their effects were screened for 720 min and time to paralyze, kill and death of each leech was recorded. The results showed that olive methanolic extractions (600 and 300mg) could kill the leeches in an average time of 145±77.57 and171±33.28 min, respectively. An average death time for levamisole was found to be 15±7.49 min. The highest effectiveness was found for levamisole at dose 300 mg. Methanol extracts of the Harmal (300 and 600 μg/m) and springs water showed no anti-leech. In sum, olive plant could use for anti Limnatis nilotica expenditure

A comparison study on the anti-leech effects of onion (Allium cepa L) and ginger (Zingiber officinale) with levamisole and triclabendazole

Introduction: Leech may indwell in mucosa of the pharynx, tonsil, esophagus, nose, nasopharyngeal and rarely in larynx of hosts, however, the effective drugs against this parasite is scarce. This study was aimed to evaluate and compare the anti-leech effect of methanolic extract of onion (Allium cepa L) and ginger (Zingiber officinale) with levamisole and triclabendazole. Materials and Methods: In this study, 60 leeches (Limnatis nilotica) were collected from south of Ilam. The anti-leech effect of methanolic extract of onion and ginger in comparison with levamisole and triclabendazole drugs (positive controls) were evaluated. Distilled water was used as negative control. Paralysis and death of leeches were recorded in 720 minutes. Results: Lethal effect of methanolic extract of ginger against Limnatis nilotica was equal to levamisole and more than triclabendazole and methanolic extract of onion. Conclusion: Ginger equal to levamisole has anti-leech activity and its methanolic extract might be used against Limnatis nilotica