Physico-chemical investigations on the sintering behaviour of red mud - flue dust composites

Two industrial waste products namely red mud and flue dust have been utilised to form composites and their sintering behaviour was investigated in this study. It has been observed that red mud alone can be sintered around 1250°C. Addition of flue dust can reduce the sintering temperature and bring it in the range of 1150 - 1200°C depending on the extent of flue dust addition (10-30%). The sintering kinetics initially follows the Johnson - Mehl model of nucleation and grain growth and subsequently beyond fractional conversion of 0.7. follows the three dimensional contracting geometry model. XRD studies reveal that there are at least 6-8 phases in the sintered product. Some of these are Fe,O, Ca,Fe,Si,Ofz, SiO,. NaAlSiO4, FeT(O,, 710, and Na,Si,O, EPMA studies show that apart from the above phases, smaller amounts of ZrSiO, and a few other rare earth compounds were also present in the sintered product. The silicate phases are essentially present in the grain boundaries of other non-silicate phases and these phases are responsible for reduction in the sintering temperature. These glassy phases are also responsible for inter-particle bonding in the composites. This conclusion has also been verified through scanning electron microscopy (SEM). The sintering temperature and fraction of the flue dust in the composites have been optimised at 1200°C and 20% respectively

Instability of Quark Matter Core in a Compact Newborn Neutron Star With Moderately Strong Magnetic Field

It is explicitly shown that if phase transition occurs at the core of a newborn neutron star with moderately strong magnetic field strength, which populates only the electron's Landau levels, then in the $\beta$-equilibrium condition, the quark core is energetically much more unstable than the neutron matter of identical physical condition.Comment: Six pages REVTEX file, one .eps file (included

Neutrino Anomalies and Quasi-Dirac neutrinos

We discuss possibility of describing solar, atmospheric and LSND results with four neutrinos forming two quasi-degenerate pairs. The simplest versions of this 2+2 scheme with either $\nu_e$ or $\nu_\mu$ mixing exclusively with sterile neutrino is disfavored by the SNO and atmospheric neutrino results respectively. A generalized scheme with sterile state participating in both the solar and atmospheric oscillations is still allowed. We show thasolar and atmospheric oscillations is still allowed. We show that the complex pattern of mixing needed for this purpose follows from a simple L_e+L_\mu-L_\tau-L_s symmetry. Specific form of L_e+L_\mu-L_\tau-L_s symmetric mass matrix is determined from experimental results. Two theoretical schemes which lead to this form and a proper breaking of L_e+L_\mu-L_\tau-L_s symmetry are discussed.Comment: 15 pages, LATEX, minor corrections; addition of few reference

Physiological and pathological roles of LRRK2 in the nuclear envelope integrity

Mutations in LRRK2 cause autosomal dominant and sporadic Parkinson’s disease but the mechanisms involved in LRRK2 toxicity in PD are yet to be fully understood. We found that LRRK2 translocates to the nucleus by binding to seven in absentia homolog (SIAH-1), and in the nucleus it directly interacts with lamin A/C, independent of its kinase activity. LRRK2 knockdown caused nuclear lamina abnormalities and nuclear disruption. LRRK2 disease mutations mostly abolish the interaction with lamin A/C and, similar to LRRK2 knockdown, cause disorganization of lamin A/C and leakage of nuclear proteins. Dopaminergic neurons of LRRK2 G2019S transgenic and LRRK2 -/- mice display decreased circularity of the nuclear lamina and leakage of the nuclear protein 53BP1 to the cytosol. Dopaminergic nigral and cortical neurons of both LRRK2 G2019S and idiopathic PD patients exhibit abnormalities of the nuclear lamina. Our data indicate that LRRK2 plays an essential role in maintaining nuclear envelope integrity. Disruption of this function by disease mutations suggests a novel phosphorylation-independent loss of function mechanism that may synergize with other neurotoxic effects caused by LRRK2 mutations

Lepton Flavor Violation and the Origin of the Seesaw Mechanism

The right--handed neutrino mass matrix that is central to the understanding of small neutrino masses via the seesaw mechanism can arise either (i) from renormalizable operators or (ii) from nonrenormalizable or super-renormalizable operators, depending on the symmetries and the Higgs content of the theory beyond the Standard Model. In this paper, we study lepton flavor violating (LFV) effects in the first class of seesaw models wherein the \nu_R Majorana masses arise from renormalizable Yukawa couplings involving a B-L = 2 Higgs field. We present detailed predictions for \tau -> \mu + \gamma and \mu -> e + \gamma branching ratios in these models taking the current neutrino oscillation data into account. Focusing on minimal supergravity models, we find that for a large range of MSSM parameters suggested by the relic abundance of neutralino dark matter and that is consistent with Higgs boson mass and other constraints, these radiative decays are in the range accessible to planned experiments. We compare these predictions with lepton flavor violation in the second class of models arising entirely from the Dirac Yukawa couplings. We study the dependence of the ratio r \equiv B(\mu -> e+\gamma)/B(\tau ->\mu +\gamma) on the MSSM parameters and show that measurement of r can provide crucial insight into the origin of the seesaw mechanism.Comment: 20 pages, Revtex, 7 figure

Intervention effects of Ganoderma lucidum spores on epileptiform discharge hippocampal neurons and expression of Neurotrophin-4 and N-Cadherin

Epilepsy can cause cerebral transient dysfunctions. Ganoderma lucidum spores (GLS), a traditional Chinese medicinal herb, has shown some antiepileptic effects in our previous studies. This was the first study of the effects of GLS on cultured primary hippocampal neurons, treated with Mg2+ free medium. This in vitro model of epileptiform discharge hippocampal neurons allowed us to investigate the anti-epileptic effects and mechanism of GLS activity. Primary hippocampal neurons from <1 day old rats were cultured and their morphologies observed under fluorescence microscope. Neurons were confirmed by immunofluorescent staining of neuron specific enolase (NSE). Sterile method for GLS generation was investigated and serial dilutions of GLS were used to test the maximum non-toxic concentration of GLS on hippocampal neurons. The optimized concentration of GLS of 0.122 mg/ml was identified and used for subsequent analysis. Using the in vitro model, hippocampal neurons were divided into 4 groups for subsequent treatment i) control, ii) model (incubated with Mg2+ free medium for 3 hours), iii) GLS group I (incubated with Mg2+ free medium containing GLS for 3 hours and replaced with normal medium and incubated for 6 hours) and iv) GLS group II (neurons incubated with Mg2+ free medium for 3 hours then replaced with a normal medium containing GLS for 6 hours). Neurotrophin-4 and N-Cadherin protein expression were detected using Western blot. The results showed that the number of normal hippocampal neurons increased and the morphologies of hippocampal neurons were well preserved after GLS treatment. Furthermore, the expression of neurotrophin-4 was significantly increased while the expression of N-Cadherin was decreased in the GLS treated group compared with the model group. This data indicates that GLS may protect hippocampal neurons by promoting neurotrophin-4 expression and inhibiting N-Cadherin expression

Minimal SUSY SO(10) model and predictions for neutrino mixings and leptonic CP violation

We discuss a minimal Supersymmetric SO(10) model where B-L symmetry is broken by a {\bf 126} dimensional Higgs multiplet which also contributes to fermion masses in conjunction with a {\bf 10} dimensional superfield. This minimal Higgs choice provides a partial unification of neutrino flavor structure with that of quarks and has been shown to predict all three neutrino mixing angles and the solar mass splitting in agreement with observations, provided one uses the type II seesaw formula for neutrino masses. In this paper we generalize this analysis to include arbitrary CP phases in couplings and vevs. We find that (i) the predictions for neutrino mixings are similar with $U_{e3}\simeq 0.18$ as before and other parameters in a somewhat bigger range and (ii) that to first order in the quark mixing parameter $\lambda$ (the Cabibbo angle), the leptonic mixing matrix is CP conserving. We also find that in the absence of any higher dimensional contributions to fermion masses, the CKM phase is different from that of the standard model implying that there must be new contributions to quark CP violation from the supersymmetry breaking sector. Inclusion of higher dimensional terms however allows the standard model CKM phase to be maintained.Comment: 22 pages, 6 figure

Study of deposition parameters for the fabrication of ZnO thin films using femtosecond laser

Femtosecond (fs) pulsed laser deposition (fs-PLD) of ZnO thin film on borosilicate glass substrates is reported in this work. The effect of important fs-PLD parameters such as target–substrate distance, laser pulse energy and substrate temperature on structure, morphology, optical transparency and luminescence of as-deposited films is discussed. XRD analysis reveals that all the films grown using the laser energy range 120–230 μJ are polycrystalline when they are deposited at room temperature in a ~10−5 Torr vacuum. Introducing 0.7 mTorr oxygen pressure, the films show preferred c-axis growth and transform into a single-crystal-like film when the substrate temperature is increased to 100 °C. The scanning electron micrographs show the presence of small nano-size grains at 25 °C, which grow in size to the regular hexagonal shape particles at 100 °C. Optical transmission of the ZnO film is found to increase with an increase in crystal quality. Maximum transmittance of 95 % in the wavelength range 400–1400 nm is achieved for films deposited at 100 °C employing a laser pulse energy of 180 μJ. The luminescence spectra show a strong UV emission band peaked at 377 nm close to the ZnO band gap. The shallow donor defects increase at higher pulse energies and higher substrate temperatures, which give rise to violet-blue luminescence. The results indicate that nano-crystalline ZnO thin films with high crystalline quality and optical transparency can be fabricated by using pulses from fs lasers