Construction of Supergravity Backgrounds with a Dilaton Field

A new class of non-compact Kahler backgrounds accompanied by a non-constant dilaton field is constructed as a supergravity solution. It is interpreted as a complex line bundle over a base manifold comprising of a combination of arbitrary coset spaces, and also includes the case of Calabi-Yau manifolds. The resulting backgrounds have U(1) isometry. We consider N=2 supersymmetric sigma-models on them, and derive a non-Kahlerian solution by U(1) duality transformation, which preserves N=2 supersymmetry.Comment: 13 pages, minor correction

UVA ユウドウ ヒフ ヒカリロウカ ニオケル シシツ カサンカブツ ノ ヤクワリ ト コウサンカ ブッシツ セッシュ ノ エイキョウ

Role of ultraviolet A（UVA）on oxidative damage has attracted much attention in relation to skin photoaging process. In this study, we investigated effect of cholesterol hydroperoxides（Chol- OOHs）, stable products of reactive oxygen species（ROS）-induced lipid peroxidation, on matrix metalloproteinase（MMP）activation responsible for wrinkle formation in hairless mouse skin and then estimated the inhibition of UVA-induced MMP activation by dietary β-carotene. Hairless mice were exposed to UVA irradiation for 8 weeks. Chol-OOHs content in the skin was found to increase significantly by the exposure of UVA. In addition, the activity of MMP-9 and its protein expression were elevated with wrinkle formation. This activation was also induced by intracutaneous injection of Chol-OOHs. Interestingly, dietary β-carotene（500 mg/kg diet） and α-tocopherol （100 mg/kg diet）suppressed the accumulation of Chol-OOH as well as MMP activation. These results suggest that Chol-OOHs formed by the exposure of UVA to skin contribute to the activation of MMPs resulting in skin photoaging. Dietary antioxidants may prevent skin photoaging through, at least partly, the suppression of MMP activation due to UVA-induced lipid peroxidation

The experience of a COVID-19 cluster in a clinical training hospital

We experienced a hospital cluster of COVID-19 in April 2021. The index case developed respiratory failure during hospitalization and was diagnosed with COVID-19 on day 8 of admission. Eleven people in the same ward were diagnosed with COVID-19 in relation to the case. All the patient in the ward were isolated. The ward stopped accepting new admissions. A task force was set up to conduct COVID-19 screening, infection control, patients and family support, and public information. No new cases occurred after day 12 of the outbreak. We started accepting new admissions to the ward on day 24, and declared convergence on day 47 of the outbreak. Since COVID-19 epidemic, our hospital had been developing infection control such as preoperative screening and providing education to the medical staff on infection prevention, which was not enough to prevent from the occurrence and spread of the COVID-19 nosocomial infections. The author, who was a clinical resident in the clinical training hospital at the time, experienced the outbreak and the process how it had been converged. From the resident’s perspective, we analyzed the factors that caused the outbreak, and discussed the efforts we had taken to converge it

The effects of chemotherapy-induced alopecic experience on daily living

がん化学療法に伴う脱毛体験が患者の日常生活にもたらす影響について明らかにすることを目的に，１５名の患者に対して自由回答法による半構造化面接を実施した．同意を得て録音した面接内容の逐語録をデータとして，Krippendorff. Kの内容分析の手法を用いて分析を行った．分析の結果，がん化学療法に伴う脱毛体験が患者の日常生活にもたらす影響として，【脱毛した自分に違和感を感じながら人目を気にして生活する】【脱毛に備えて事前に準備する】【脱毛は仕方がないと捉え治療を受けることを優先させる】【予想以上の急速大量脱毛にがんであることの事実を突きつけられる】【時間をかけて脱毛の事実を受け入れ違う捉え方を見出す努力をする】【他者と距離を取りながら生活する】【立場，性差による脱毛の捉え方の違いを実感する】【脱毛した毛髪の処理を気にかけながら生活する】【脱毛のつらい経験から検診の啓蒙活動を行う】の９つが明らかとなった．脱毛に対して事前に十分な準備が行え，自分なりの対処法についてイメージできるよう具体的な情報提供を行うとともに，性差，治療効果や患者の治療への思いなどによって脱毛に対する捉え方はさまざまであることから，看護師はその人自身の脱毛の受け止め方や，脱毛が及ぼす生活への支障について把握し，必要な情報を提供することや患者の思いが表出しやすい環境を整えることが大切である．The present study aimed to clarify the effects of chemotherapy-induced alopecia on the daily lives of cancer patients. Semi-structured interviews comprising free-answer questions based on an interview guide were conducted on １５ cancer patients experiencing chemotherapy-induced alopecia. Analysis revealed the following ９ effects of chemotherapy-induced alopecia on patients’ daily lives : ‘self-consciousness accompanied by feeling strange about oneself due to hair loss’, ‘preparing for hair loss in advance’, ‘prioritizing treatment and perceiving hair loss as inevitable’, ‘come to terms with chemotherapy-induced alopecia gradually, make an effort to find out a different kind of ways for it’, ‘being hit by the reality of cancer due to greater than anticipated rapid loss of large quantities of hair’, ‘intentionally living daily life at a distance from others’, ‘recognizing the situation and the gender-based differences in perception of hair loss’, ‘worrying about disposing of the lost hair’, ‘becoming more informed about medical examinations due to the hard experience of hair loss’. The present findings indicated that chemotherapy-induced alopecia is perceived in various ways depending on gender, treatment effectiveness and patients’ feelings towards treatment. It is important for nurses to understand patients’ individual acceptance of alopecia and related difficulties in daily life while creating an environment that allows patients to express their feelings. Nurses should also provide specific information enabling patients to visualize personal coping techniques and sufficiently prepare for alopecia

プロテインC カッセイ テイカ オ ハイケイ トシ オートマチックシャ エノ ヘンコウ オ ケイキ ニ ハイケッセン ソクセンショウ オ ハッショウ シタ タクシー ウンテンシュ ノ イチレイ

A ６２-year-old man, who was a taxi-driver, presented to our hospital for further examination and treatment of deep venous thrombosis（DVT）suspected in another clinic. Before ３ months of consultation, he had changed his taxi from manual transmission car to automatic transmission car. Around the same time, he had complained progressively worsening left pedal edema and pain. When he consulted our hospital, blood examination showed elevated D-dimer and deficiency of protein C. A venous ultrasound showed an occlusive DVT in left lower extremity through an external iliac vein. A contrast-enhanced computed tomography showed bilateral pulmonary embolism（PE） and extensive thrombus in the left lower extremity. Following hospitalization, an inferior vena cava （IVC）filter was placed in an infrarenal IVC position, and anticoagulant therapy was initiated with heparin and warfarin. His DVT and PE were managed successfully with anticoagulant therapy, and pedal edema was improved. Besides some risk factors of thrombogenicity such as age and deficiency of protein C, sitting position for long hours and decreased motion of left leg might have triggered off the thrombus formation in the left lower extremity. This report demonstrates the importance of careful follow-ups to long-distance drivers with risk factors of thrombus formation, especially about clutch operation

Lifestyle Habits Adjustment for Hypertension and Discontinuation of Antihypertensive Agents

Background: Hypertension is one of lifestyle-related diseases, and prevention and effect of reduction pressure can be expected by non-pharmacological interventions. Authors have continued guidance of adjustment for lifestyle to thousands of hypertensive patients, resulting 4.6%-6.1% case could discontinue hypertensive agents. This study enrolled patients with all necessary related data. Subjects and methods: Subjects were 50 patients with hypertension (M/F: 25/25, age 65.4 ± 8.6 vs. 53.4 ± 6.2 years, BMI 23.4 ± 2.7 vs. 22.3 ± 2.5, respectively), who could discontinued antihypertensive agents. They received consultation and intervention from registered dietitian nutritionists, exercise therapists and nurses. Results: The comparative results on males and females are as follows: smoking habit was 76% vs. 0%, alcohol intake was 60% vs. 0%, diabetes complication was 16% vs. 8%, and hyperlipidemia was 32% vs. 52%, respectively. These cases showed rare to none incidence of cerebral vascular accident (CVA), coronary heart disease (CHD) and chronic kidney disease (CKD). Consultations in median were 4.0 vs. 4.0 times, median weight reduction was 2.2 kg vs. 1.6 kg and median period withdrawal of the drug was 2.0 years vs. 2.5 years. Discussion and conclusion: When living adjustment is advised, blood pressure decreases due to behavior change. Our results suggest that these cases have less arteriosclerosis development, which enables withdrawal of medicine. It is necessary to carefully observe the progress whether the antihypertensive drug will be unnecessary or will be restarted. Current results obtained would become the fundamental data in the future, and the adjustment for diet and exercise would be useful for more adequate treatment for hypertension

スマートフォン ト インターネット オ モチイタ トクシマ ケンリツ カイフ ビョウイン エンカク イリョウ シエン システム k-support ノ ドウニュウ

Because a specialist in general medical treatment lacked the Kaifu area of South Tokushima absolutely, we forced a limited doctor to many burdens and performed medical treatment while I always carried risks on my back for the disease except the specialty domain. A stroke specialist in particular is an absent medical depopulated area, and it is difficult to perform the rt-PA IV therapy that is a standard therapy for a stroke for the immediate nature period. Using remote video diagnosis treatment supporting system SYNAPSE ERm that was the smartphone application that FUJIFILM developed for the purpose of canceling these, we introduced smartphone and Tokushima Prefectural Kaifu Hospital remoteness medical treatment support system （k-support） by the Internet as area medical treatment support in February, 2013. This system can provide image information and patient information such as CT or the MRI to a tablet phone and the smartphone of Tokushima Prefectural Kaifu Hospital full-time employment doctors and the doctors who support it, and work in a House in real time. In other words, we can obtain necessary information without asking the when and where and can send appropriate instructions, advice to the Tokushima Prefectural Kaifu Hospital medical attendant from a specialist for it. After introduction, the treatment with this system in 58 emergency patients was carried out in seven months until August 31. The example letting the wide area present the smartphone such as this system and a remote medical treatment support system using the Internet in the medical depopulated area is the first trial in this country

ニンシン オ ケイキ ニ ジョウミャク ケッセンショウ オ ハッショウシ センテンセイ アンチトロンビンIII ケッソンショウ ト シンダン サレタ イチレイ

Congenital antithrombin III (AT III) deficiency is an inherited autosomal dominant disorder. Patients often suffer from recurrent venous thromboses that are triggered by several occasions (operation, gestation, trauma, oral contraceptive drug etc.). Moreover, 60% of them are said to be associated with pulmonary embolism. The patient of this report is 27-year-old pregnant woman in the first trimester. She felt pain in the back of her head and left auricle and presented with dyslexia and aphasia in late of March, 20XX. Getting CT brain scan, MRI brain scan, and blood sampling at the nearby hospital, she was suspected of having thrombosis of left sigmoid and transverse sinus due to AT III deficiency. Because she wanted to give birth to her first child without termination, she was referred to our hospital. We used heparin as the anticoagulant therapy because warfarin had the risk of teratogenesis. But in condition of low serum level of AT III activity, it didn’t work effectively. So we also did frequent complement of AT III. Strict anticoagulant therapy resulted in better outcome for both the patient and her baby without fatal venous thromboses or fetal complications