81 research outputs found
Stimulation of a glycosyl-phosphatidylinositol-specific phospholipase by insulin and the sulfonylurea, glimepiride, in rat adipocytes depends on increased glucose transport.
Degenerate flag varieties: moment graphs and Schr\"oder numbers
We study geometric and combinatorial properties of the degenerate flag
varieties of type A. These varieties are acted upon by the automorphism group
of a certain representation of a type A quiver, containing a maximal torus T.
Using the group action, we describe the moment graphs, encoding the zero- and
one-dimensional T-orbits. We also study the smooth and singular loci of the
degenerate flag varieties. We show that the Euler characteristic of the smooth
locus is equal to the large Schr\"oder number and the Poincar\'e polynomial is
given by a natural statistics counting the number of diagonal steps in a
Schr\"oder path. As an application we obtain a new combinatorial description of
the large and small Schr\"oder numbers and their q-analogues.Comment: 25 page
An amphitropic cAMP-binding protein in yeast mitochondria
ABSTRACT: We describe the first example of a mitochondrial protein with a covalently attached phos-phatidylinositol moiety acting as a membrane anchor. The protein can be metabolically labeled with both stearic acid and inositol. The stearic acid label is removed by phospholipase D whereupon the protein with the retained inositol label is released from the membrane. This protein is a cAMP receptor of the yeast Saccharomyces cereuisiae and tightly associated with the inner mitochondrial membrane. However, it is converted into a soluble form during incubation of isolated mitochondria with Ca2+ and phospholipid (or lipid derivatives). This transition requires the action of a proteinaceous, N-ethylmaleimide-sensitive component of the intermembrane space and is accompanied by a decrease in the lipophilicity of the cAMP receptor. We propose that the component of the intermembrane space triggers the amphitropic behavior of the mitochondrial lipid-modified CAMP-binding protein through a phospholipase activity. Only in recent years specific fatty acids have been recog-nized to play important roles in the association of proteins with membranes. Both noncovalent and covalent interactions be-tween fatty acids and proteins have been reported. Among the latter are GTP-binding proteins (Molenaar et al., 1988)
Purification of profilin from Saccharomyces cerevisiae and analysis of profilin-deficient cells.
On the uniqueness of promotion operators on tensor products of type A crystals
The affine Dynkin diagram of type has a cyclic symmetry. The
analogue of this Dynkin diagram automorphism on the level of crystals is called
a promotion operator. In this paper we show that the only irreducible type
crystals which admit a promotion operator are the highest weight crystals
indexed by rectangles. In addition we prove that on the tensor product of two
type crystals labeled by rectangles, there is a single connected
promotion operator. We conjecture this to be true for an arbitrary number of
tensor factors. Our results are in agreement with Kashiwara's conjecture that
all `good' affine crystals are tensor products of Kirillov-Reshetikhin
crystals.Comment: 31 pages; 8 figure
Order cones: A tool for deriving k-dimensional faces of cones of subfamilies of monotone games
In this paper we introduce the concept of order cone. This concept is inspired by the concept of order polytopes, a well-known object coming from Combinatorics. Similarly to order polytopes, order cones are a special type of polyhedral cones whose geometrical structure depends on the properties of a partially ordered set (brief poset). This allows to study these properties in terms of the subjacent poset, a problem that is usually simpler to solve. From the point of view of applicability, it can be seen that many cones appearing in the literature of monotone TU-games are order cones. Especially, it can be seen that the cones of monotone games with restricted cooperation are order cones, no matter the structure of the set of feasible coalitions
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