Silica Sulfuric Acid-​Mediated Synthesis of β-​Enaminones and β-​Enaminoesters Under Microwave Irradiation

Silica sulfuric acid, a heterogeneous substance, has been found to be an efficient catalyst for the synthesis of β-​enaminones and β-​enaminoesters under in a microwave reactor within 2 min. The exptl. procedure is simple and environment-​friendly, and yields are excellent. Further, the catalyst is recyclable, and the reaction is 60 times faster than the reaction at room temp

Silica Chloride Catalyzed Efficient Route to Novel 1-Amidoalkyl-2-Naphthylamines under Sonic Condition in Water

A one-pot three-component condensation of an aldehyde, 2-naphthylamine, and acetamide has been achieved by sonication at 35 kHz. The reaction is catalysed by silica chloride in aqueous medium. This protocol afforded corresponding 1-amidoalkyl-2-naphthylamines in shorter reaction durations, and in high yields. The method involves simple work-up procedure, and avoids use of hazardous reagents

Cavitational Chemistry: A Mild and Efficient multi-component Synthesis of amidoalkyl-2-naphthols Using Reusable Silica Chloride as Catalyst under Sonic Conditions

An efficient and direct procedure for the synthesis of amidoalkyl-2-naphthol derivatives has been described. The process employs a three-component cyclocondensation reaction in one-pot using β-naphthol, aromatic aldehyde and acetamide or benzamide in the presence of silica chloride accelerated by ultrasound giving the product in excellent yield in very short duration

Silica-ZnCl 2 : An Efficient Catalyst for the Synthesis of 4-Methylcoumarins

Silica-ZnCl2 has been found to be an efficient and eco-friendly catalyst for the synthesis of substituted 4-methylcoumarins from ethyl acetoacetate and substituted phenols under “neat” conditions in an oil bath at 80°C. The experimental procedure is simple, includes shorter reaction times (15–65 min), compatible with sensitive functional groups, and results in excellent yield of the products

Mechanochemistry: An efficient method of solvent-free synthesis of 3-amino-2,4-dicarbonitrile-5-methylbiphenyls

3-Amino-2,4-dicarbonitrile-5-methylbiphenyls are synthesized by a three-component reaction of aromatic aldehydes, malononitrile, and acetone in the presence of catalytic NaOMe under grindstone method. The yields are excellent; the procedure is simple, efficient, and environmentally benign; and all the reactions go to completion within 2–3 min

One-pot synthesis of functionalized beta-amino sulfides/beta-amino selenides via ring opening of cyclic sulfamidates

A number of functionalized beta-amino and gamma-amino sulfides and selenides have been synthesized involving a one-pot process of ring opening of cyclic sulfamidates with `in situ' generated thiolate and selenoate species from diaryl disulfides and diphenyl diselenide using rongalite. A mild and efficient method has been developed for the synthesis of cysteines from serine