10 research outputs found
Silica Sulfuric Acid-Mediated Synthesis of β-Enaminones and β-Enaminoesters Under Microwave Irradiation
Silica sulfuric acid, a heterogeneous substance, has been found to be an efficient catalyst for the synthesis of β-enaminones and β-enaminoesters under in a microwave reactor within 2 min. The exptl. procedure is simple and environment-friendly, and yields are excellent. Further, the catalyst is recyclable, and the reaction is 60 times faster than the reaction at room temp
Silica Chloride Catalyzed Efficient Route to Novel 1-Amidoalkyl-2-Naphthylamines under Sonic Condition in Water
A one-pot three-component condensation of an aldehyde, 2-naphthylamine, and acetamide has been achieved by sonication at 35 kHz. The reaction is catalysed by silica chloride in aqueous medium. This protocol afforded corresponding 1-amidoalkyl-2-naphthylamines in shorter reaction durations, and in high yields. The method involves simple work-up procedure, and avoids use of hazardous reagents
Cavitational Chemistry: A Mild and Efficient multi-component Synthesis of amidoalkyl-2-naphthols Using Reusable Silica Chloride as Catalyst under Sonic Conditions
An efficient and direct procedure for the synthesis of amidoalkyl-2-naphthol derivatives has been described. The process employs a three-component cyclocondensation reaction in one-pot using β-naphthol, aromatic aldehyde and acetamide or benzamide in the presence of silica chloride accelerated by ultrasound giving the product in excellent yield in very short duration
Silica-ZnCl 2 : An Efficient Catalyst for the Synthesis of 4-Methylcoumarins
Silica-ZnCl2 has been found to be an efficient and eco-friendly catalyst for the synthesis of substituted 4-methylcoumarins from ethyl acetoacetate and substituted phenols under “neat” conditions in an oil bath at 80°C. The experimental procedure is simple, includes shorter reaction times (15–65 min), compatible with sensitive functional groups, and results in excellent yield of the products
Chemoselective Protection and Deprotection of Aldehydes Using Solid Supported Reagent (Silica Chloride) Under Solvent-Free Conditions
Mechanochemistry: An efficient method of solvent-free synthesis of 3-amino-2,4-dicarbonitrile-5-methylbiphenyls
3-Amino-2,4-dicarbonitrile-5-methylbiphenyls are synthesized by a three-component reaction of aromatic aldehydes, malononitrile, and acetone in the presence of catalytic NaOMe under grindstone method. The yields are excellent; the procedure is simple, efficient, and environmentally benign; and all the reactions go to completion within 2–3 min
One-pot synthesis of functionalized beta-amino sulfides/beta-amino selenides via ring opening of cyclic sulfamidates
A number of functionalized beta-amino and gamma-amino sulfides and selenides have been synthesized involving a one-pot process of ring opening of cyclic sulfamidates with `in situ' generated thiolate and selenoate species from diaryl disulfides and diphenyl diselenide using rongalite. A mild and efficient method has been developed for the synthesis of cysteines from serine