The geography of taste: analyzing cell-phone mobility and social events

This paper deals with the analysis of crowd mobility during special events. We analyze nearly 1 million cell-phone traces and associate their destinations with social events. We show that the origins of people attending an event are strongly correlated to the type of event, with implications in city management, since the knowledge of additive flows can be a critical information on which to take decisions about events management and congestion mitigation

A guided tour of asynchronous cellular automata

Research on asynchronous cellular automata has received a great amount of attention these last years and has turned to a thriving field. We survey the recent research that has been carried out on this topic and present a wide state of the art where computing and modelling issues are both represented.Comment: To appear in the Journal of Cellular Automat

Protective continuous ventilation strategy during cardiopulmonary bypass in children undergoing surgery for congenital heart disease: a prospective study

OBJECTIVES: The aim of this study was to evaluate if a 'protective' (low-tidal/low-frequency) ventilation strategy can shorten the postoperative ventilation time and minimize acute lung injury in children with congenital heart disease (CHD) undergoing repair with cardiopulmonary bypass (CPB). METHODS: This is a single-centre prospective, interventional study, including children with CHD under the age of 5 years, undergoing open-heart surgery with a CPB >60 min, in hypothermia, haemodynamically stable, and without evident genetic abnormalities. Assist-control ventilation (tidal volume of 4 ml/kg, 10 breaths/min, positive end-expiratory pressure 5 cmH2O and FiO2 0.21) was applied in a cohort of patients during CPB. We compared clinical outcomes and in fully ventilated versus non-ventilated (control) patients. Propensity score was used to weigh ventilated and control groups to correct for the effect of other confounding clinical variables. Clinical and ventilation parameters and lung inflammatory biomarkers in tracheal aspirates were measured. The primary outcome was the postoperative intubation time of more or less than 48 h. RESULTS: We included 140 children (53 ventilated, 87 non-ventilated) with different CHD. There were no deaths or adverse events in ventilated patients. Using a weighted generalized linear model, we found no sufficient evidence for an effect of intraoperative ventilation on postoperative intubation time [estimate 0.13 (95% confidence interval, -0.08; 0.35), P = 0.22]. CONCLUSIONS: Continuous low-tidal/low-frequency mechanical ventilation during CPB is safe and harmless. However, no significant advantages were found when compared to non-ventilated patients in terms of postoperative ventilation time

Delivery of thyronamines (TAMs) to the brain: A preliminary study

Recent reports highlighted the significant neuroprotective effects of thyronamines (TAMs), a class of endogenous thyroid hormone derivatives. In particular, 3-iodothyronamine (T1AM) has been shown to play a pleiotropic role in neurodegeneration by modulating energy metabolism and neurological functions in mice. However, the pharmacological response to T1AM might be influenced by tissue metabolism, which is known to convert T1AM into its catabolite 3-iodothyroacetic acid (TA1). Currently, several research groups are investigating the pharmacological effects of T1AM systemic administration in the search of novel therapeutic approaches for the treatment of interlinked pathologies, such as metabolic and neurodegenerative diseases (NDDs). A critical aspect in the development of new drugs for NDDs is to know their distribution in the brain, which is fundamentally related to their ability to cross the blood–brain barrier (BBB). To this end, in the present study we used the immortalized mouse brain endothelial cell line bEnd.3 to develop an in vitro model of BBB and evaluate T1AM and TA1 permeability. Both drugs, administered at 1 µM dose, were assayed by high-performance liquid chromatography coupled to mass spectrometry. Our results indicate that T1AM is able to efficiently cross the BBB, whereas TA1 is almost completely devoid of this property

A stochastic cellular automaton model for traffic flow with multiple metastable states

A new stochastic cellular automaton (CA) model of traffic flow, which includes slow-to-start effects and a driver's perspective, is proposed by extending the Burgers CA and the Nagel-Schreckenberg CA model. The flow-density relation of this model shows multiple metastable branches near the transition density from free to congested traffic, which form a wide scattering area in the fundamental diagram. The stability of these branches and their velocity distributions are explicitly studied by numerical simulations.Comment: 11 pages, 20 figures, submitted for publicatio

Programa de prevenção e controle da anemia infecciosa eqüina no Pantanal Sul-Mato-Grossense.

A Anemia Infecciosa Eqüina (AIE), conhecida mundialmente como febre-do-pântano, é causada por um retrovírus pertencente à subfamília dos lentivírus, que infecta membros da família Equidae. Os estudos iniciais dessa doença foram realizados na França, no século XIX, e, atualmente, apresenta distribuição mundial. A AIE é uma infecção persistente, resultando em episódios periódicos de febre, anemia, hemorragias, redução no número de glóbulos brancos e plaquetas com supressão transitória da resposta imunológica. Sinais clínicos como perda de peso, depressão , desorientação, andar em círculos e febre tem sido observados. Muitos animais não apresentam qualquer sinal clínico (portadores assintomáticos) associado à AIE. O aproveitamento de potros negativos, oriundos de éguas positivas para AIE, é possível, visto que os potros raramente apresentam-se infectados ao nascimento. O desmame dos potros deve ser realizado aos seis meses de idade. Antes dessa idade, a maioria dos potros apresenta resultados positivos ao exame de AIE (IDGA), provavelmente por causa dos anticorpos presentes no colostro, os quais permanecem circulantes no sangue. O desmame não deve ser realizado mais tarde, uma vez qua a atratividade dos potros com relação aos vetores tende a aumentar com a idade, juntamente com o risco de transmissão (Silva et al., 2001).bitstream/item/81125/1/DOC68.pd

IDH2 inhibition enhances proteasome inhibitor responsiveness in hematological malignancies

Proteasome inhibitors (PIs) are extensively used for the therapy of multiple myeloma (MM) and mantle-cell lymphoma (MCL). However, patients continuously relapse or are intrinsically resistant to this class of drugs. Here, to identify targets that synergize with PIs, we carried out a functional screening in MM cell lines using a short hairpin RNA library against cancer driver genes. Isocitrate dehydrogenase 2 (IDH2) was identified as a top candidate, showing a synthetic lethal activity with the PI carfilzomib (CFZ). Combinations of FDA approved PIs with a pharmacological IDH2 inhibitor (AGI-6780) triggered synergistic cytotoxicity in MM, MCL, and Burkitt's lymphoma (BL) cell lines. CFZ/AGI-6780 treatment increased death of primary CD138+ cells from MM patients and exhibited a favorable cytotoxicity profile towards peripheral blood mononuclear cells and bone marrow-derived stromal cells. Mechanistically, CFZ/AGI-6780 combination significantly decreased tricarboxylic acid (TCA) cycle activity and ATP levels, as a consequence of enhanced IDH2 enzymatic inhibition. Specifically, CFZ treatment reduced the expression of nicotinamide phosphoribosyltransferase (NAMPT), thus limiting IDH2 activation through the NAD+-dependent deacetylase SIRT3. Consistently, combination of CFZ with either NAMPT or SIRT3 inhibitors impaired IDH2 activity and increased MM cell death. Finally, inducible IDH2 knockdown enhanced the therapeutic efficacy of CFZ in a subcutaneous xenograft model of MM, resulting in inhibition of tumor progression and extended survival. Taken together, these findings indicate that NAMPT/SIRT3/IDH2 pathway inhibition enhances the therapeutic efficacy of PIs, thus providing compelling evidence for treatments with lower and less toxic doses and broadening the application of PIs to other malignancies