Multivariable analysis results for overall survival (phase I; n = 234).

<p>CI: confidence interval, HR: hazard ratio, MSI-H: microsatellite instability-high, MSI-L: microsatellite instability-low, MSS: microsatellite stable. Significant associations (p<0.05) are shown in bold.</p><p>Multivariable analysis results for overall survival (phase I; n = 234).</p

Baseline characteristics of the phase I cohort.

<p>(+): present, (−): absent, DFS: disease free survival, DSS: disease specific survival, MSI-H: microsatellite instability-high, MSI-L: microsatellite instability-low, MSS: microsatellite stable, OS: overall survival.</p><p>Baseline characteristics of the phase I cohort.</p

Baseline characteristics of the phase II cohort.

<p>(+): present, (−): absent, DFS: disease free survival, MSI-H: microsatellite instability-high, MSI-L: microsatellite instability-low, MSS: microsatellite stable, OS: overall survival.</p><p>Baseline characteristics of the phase II cohort.</p

SNP: single nucleotide polymorphism.

<p>SNP: single nucleotide polymorphism.</p

Multivariable analysis results for overall survival (phase II; n = 477).

<p>(+): present, (−): absent, CI: confidence interval, HR: hazard ratio, MSI-H: microsatellite instability-high, MSI-L: microsatellite instability-low, MSS: microsatellite stable. Significant associations (p<0.05) are shown in bold.</p><p>Multivariable analysis results for overall survival (phase II; n = 477).</p