Varying R² and P_SNP cutoffs for the ADRA1 Pathway.

<p>Varying R² and P_SNP cutoffs for the ADRA1 Pathway.</p

Descriptive characteristics of phenotypes among study participants.

<p>Values are expressed as mean±SD.</p

ADRA1 pathway associated genes. Gene names are in italics.

<p>Regulators are in circles. TH, tyrosine hydroxylase; DDC, dopa decarboxylase; DBH, dopamine beta hydroxylase; PNMT, phenylethanolamine N-methyltransferase; ADRA1A, ADRA1B, ADRA1D, adrenergic alpha 1 receptors; GNAQ, guanine nucleotide binding protein, Q; GNA11, guanine nucleotide binding protein, alpha 11; PLCB3, phospholipase C, beta 3; ITPR1, inositol 1,4,5-triphosphate receptor, type 1; POMC, proopiomelanocortin; COMT, catechol-o-methyltransferase; MAO, monoamine oxidase; RGS 2,4,5, regulator of g-protein signaling.</p

Pathway Association Results.

*<p>p-value is significant after correction for multiple testing.</p>†<p>ADRA1, -receptors is the same pathway as ADRA1, with the ADRA1 receptor genes removed from the model.</p><p>Adjustment was made for sex, age, age² and BMI for all models.</p

Line graphs representing the ADRA1 pathway genetic risk model for DBP, SBP, and hypertension (HTN).

<p>The risk score was divided into quintiles, with the reference category being the lowest risk score quintile. * P<0.05. ** P<0.005. ***P<0.0001.</p

Distributions of numbers of nuclear families and inheritance vector bit in the 1919 pedigrees.

<p>Distributions of numbers of nuclear families and inheritance vector bit in the 1919 pedigrees.</p

Distribution of ovarian cancer affection status among relationship pairs.

<p>Distribution of ovarian cancer affection status among relationship pairs.</p

Parameter estimates from segregation analysis of ovarian cancer in 1919 proband-ascertained pedigrees.

†<p>Parameters in square brackets were fixed at the values indicated; <b>^‡</b>M indicates Mendelian transmission: τ_AA = 1.0, τ_AB = 0.5, τ_BB = 0.0.</p>§<p>The meaning of γ parameters is as follows: ^γ_md represents mother/daughter residual association; ^γ_ss represents sister/sister residual association; <b>^*</b>Parameter hit bound; <b>^§</b>No. of independent parameters: (no. of parameters in model) – (no. of parameters fixed at boundary) – (no. of dependent and or fixed parameters); Chi-square is defined as (-2 ln L) of the data under the specific hypothesis minus (−2 ln L) of the data under the general model.</p

Plot showing distributions of number of generations in the 1919 pedigrees.

<p>Plot showing distributions of number of generations in the 1919 pedigrees.</p

Distribution of relationship types in the study sample.

‡<p>Values in parentheses indicate number of dummy individuals used for the purpose of pedigree connections and who were not considered in analysis. These dummies were mostly pedigree founders.</p