Trigeminal Nevraljide Ayırıcı Tanının Önemi

Trigeminal nevralji (TN), trigeminal sinirin bir veya daha fazla dalı boyunca uzanan, tekrarlayan bıçak saplanması şeklindeki ağrılarla karakterize ve çoğunlukla çiğneme ya da dişetlerinin manüplasyonu ile tetiklenen bir hastalıktır. TN ağrılarının başlangıçtaki atipik semptomları pre-trigeminal nevralji (PTN) olarak adlandırılır. Bu çalışmanın amacı, oral PTN semptomlarının daha iyi tanımlanarak, PTN ve odontojenik diş ağrısı arasındaki farkların anlaşılabilmesi ve mikrovasküler dekompresyon (MVD) yönteminin TN tedavisindeki etkinliğinin değerlendirilmesidir. Daha önce TN tanısı konmuş toplam 11 hasta (4 kadın, 7 erkek; ortalama yaş: 57,72) retrospektif olarak incelendi. Pamukkale Üniversitesi Tıp Fakültesi Nöroşirürji Kliniği'nde bu 11 hastaya MVD operasyonu yapıldı. TN her hekim tarafından tanısı konabilecek bir hastalık olmakla birlikte özellikle PTN'nin tanınması ve diş hekimlerinin ayırıcı tanı konusunda bilgili olmaları hastaların tedavilerinin yapılması ve ağrılarından kurtulmaları açısınan çok önemlidir. TN tedavisinde şu ana kadar bilinen en iyi tedavi metodu olan MVD yöntemi, hastaların ağrılarının tamamen geçmesini sağlayan bir tedavi yöntemidir. Çalışmamızda, MVD'nin hastalara ağrısız bir hayat sunduğu gösterilmiştir

A biochemical and immunohistochemical study of the effects of caffeic acid phenethyl ester on alveolar bone loss and oxidative stress in diabetic rats with experimental periodontitis

Caffeic acid phenethyl ester (CAPE) is used as a therapeutic agent to prevent bone loss. We determined the effects of systemically administered CAPE on alveolar bone loss and oxidative stress in diabetic rats with experimental periodontitis. Forty male rats were divided into four equal groups: control, experimental periodontitis (EP), EP-diabetes mellitus (EP-DM) and EP-DM-CAPE. DM was induced by streptozotocin, then lipopolysaccharide was injected to induce periodontitis. CAPE was administered to the EP-DM-CAPE group daily for 15 days. Then, serum samples were taken and the rats were sacrificed for histological analyses. Serum interleukin (IL-1ß) and oxidative stress also were evaluated. Alveolar bone loss was assessed histomorphometrically. Alveolar bone loss and IL-1ß levels were significantly less in the EP-DM-CAPE and EP groups compared to the EP-DM group. Oxidative stress was significantly less in the EP-DM-CAPE group compared to the EP and EP-DM groups. Receptor activator of nuclear factor kappa-B ligand (RANKL) levels were significantly higher in the EP-DM group compared to the disease groups. CAPE significantly reduced RANKL levels in the EP-DM-CAPE group compared to the EP-DM group. We found that CAPE treatment significantly inhibited DM induced oxidative stress and RANKL induced osteoclastogenesis and alveolar bone loss in diabetic rats with periodontitis. © 2020, © 2020 The Biological Stain Commission

Gingival crevicular fluid tissue/blood vessel-type plasminogen activator and plasminogen activator inhibitor-2 levels in patients with rheumatoid arthritis: effects of nonsurgical periodontal therapy

Background and Objective: The aim of this study was to evaluate the effect of nonsurgical periodontal therapy on clinical parameters and gingival crevicular fluid levels of tissue/blood vessel-type plasminogen activator (t-PA) and plasminogen activator inhibitor-2 (PAI-2) in patients with periodontitis, with or without rheumatoid arthritis (RA). Material and Methods: Fifteen patients with RA and chronic periodontitis (RA-P), 15 systemically healthy patients with chronic periodontitis (H-P) and 15 periodontally and systemically healthy volunteers (C) were included in the study. Plaque index, gingival index, probing pocket depth, clinical attachment level, bleeding on probing, gingival crevicular fluid t-PA and PAI-2 levels, erythrocyte sedimentation rate, serum C-reactive protein and disease activity score were evaluated at baseline and 3 mo after mechanical nonsurgical periodontal therapy. Results: All periodontal clinical parameters were significantly higher in the RA-P and H-P groups compared with the C group (p 0.001) and decreased significantly after treatment (p 0.001). Pretreatment t-PA levels were highest in the RA-P group and significantly decreased post-treatment (p = 0.047). Pre- and post-treatment PAI-2 levels were significantly lower in controls compared with both periodontitis groups (p 0.05). Gingival crevicular fluid volume and the levels of t-PA and PAI-2 were significantly correlated. Conclusion: In patients with periodontitis and RA, nonsurgical periodontal therapy reduced the pretreatment gingival crevicular fluid t-PA levels, which were significantly correlated with gingival crevicular fluid PAI-2 levels. The significantly higher t-PA and PAI-2 gingival crevicular fluid levels in periodontal patients, regardless of systemic status, suggest that the plasminogen activating system plays a role in the disease process of periodontitis. © 2016 John Wiley ; Sons A/S. Published by John Wiley ; Sons Lt

Gingival crevicular fluid tissue/blood vessel-type plasminogen activator and plasminogen activator inhibitor-2 levels in patients with rheumatoid arthritis: Effects of nonsurgical periodontal therapy

WOS: 000399955500030PubMed ID: 27781272Background and ObjectiveThe aim of this study was to evaluate the effect of nonsurgical periodontal therapy on clinical parameters and gingival crevicular fluid levels of tissue/blood vessel-type plasminogen activator (t-PA) and plasminogen activator inhibitor-2 (PAI-2) in patients with periodontitis, with or without rheumatoid arthritis (RA). Material and MethodsFifteen patients with RA and chronic periodontitis (RA-P), 15 systemically healthy patients with chronic periodontitis (H-P) and 15 periodontally and systemically healthy volunteers (C) were included in the study. Plaque index, gingival index, probing pocket depth, clinical attachment level, bleeding on probing, gingival crevicular fluid t-PA and PAI-2 levels, erythrocyte sedimentation rate, serum C-reactive protein and disease activity score were evaluated at baseline and 3 mo after mechanical nonsurgical periodontal therapy. ResultsAll periodontal clinical parameters were significantly higher in the RA-P and H-P groups compared with the C group (p < 0.001) and decreased significantly after treatment (p < 0.001). Pretreatment t-PA levels were highest in the RA-P group and significantly decreased post-treatment (p = 0.047). Pre- and post-treatment PAI-2 levels were significantly lower in controls compared with both periodontitis groups (p < 0.05). Gingival crevicular fluid volume and the levels of t-PA and PAI-2 were significantly correlated. ConclusionIn patients with periodontitis and RA, nonsurgical periodontal therapy reduced the pretreatment gingival crevicular fluid t-PA levels, which were significantly correlated with gingival crevicular fluid PAI-2 levels. The significantly higher t-PA and PAI-2 gingival crevicular fluid levels in periodontal patients, regardless of systemic status, suggest that the plasminogen activating system plays a role in the disease process of periodontitis.Ankara University Scientific Research Projects Office, Ankara, Turkey [08B3334005]This study was supported by the Ankara University Scientific Research Projects Office, Ankara, Turkey (08B3334005). The authors declare that they have no conflicts of interest