7,046 research outputs found

    Two-loop three-gluon vertex in zero-momentum limit

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    The two-loop three-gluon vertex is calculated in an arbitrary covariant gauge, in the limit when one of the external momenta vanishes. The differential Ward-Slavnov-Taylor (WST) identity related to this limit is discussed, and the relevant results for the ghost-gluon vertex and two-point functions are obtained. Together with the differential WST identity, they provide another independent way for calculating the three-gluon vertex. The renormalization of the results obtained is also presented.Comment: 22 pages, LaTeX, including 4 figures, uses eps

    Auxiliary subunit regulation of high-voltage activated calcium channels expressed in mammalian cells

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    The effects of auxiliary calcium channel subunits on the expression and functional properties of high-voltage activated (HVA) calcium channels have been studied extensively in the Xenopus oocyte expression system, but are less completely characterized in a mammalian cellular environment. Here, we provide the first systematic analysis of the effects of calcium channel beta and alpha(2)-delta subunits on expression levels and biophysical properties of three different types (Ca(v)1.2, Ca(v)2.1 and Ca(v)2.3) of HVA calcium channels expressed in tsA-201 cells. Our data show that Ca(v)1.2 and Ca(v)2.3 channels yield significant barium current in the absence of any auxiliary subunits. Although calcium channel beta subunits were in principle capable of increasing whole cell conductance, this effect was dependent on the type of calcium channel alpha(1) subunit, and beta(3) subunits altogether failed to enhance current amplitude irrespective of channel subtype. Moreover, the alpha(2)-delta subunit alone is capable of increasing current amplitude of each channel type examined, and at least for members of the Ca(v)2 channel family, appears to act synergistically with beta subunits. In general agreement with previous studies, channel activation and inactivation gating was regulated both by beta and by alpha(2)-delta subunits. However, whereas pronounced regulation of inactivation characteristics was seen with the majority of the auxiliary subunits, effects on voltage dependence of activation were only small (< 5 mV). Overall, through a systematic approach, we have elucidated a previously underestimated role of the alpha(2)-delta(1) subunit with regard to current enhancement and kinetics. Moreover, the effects of each auxiliary subunit on whole cell conductance and channel gating appear to be specifically tailored to subsets of calcium channel subtypes

    Why Pad\'e Approximants reduce the Renormalization-Scale dependence in QFT?

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    We prove that in the limit where the beta function is dominated by the 1-loop contribution (``large beta_0 limit'') diagonal Pad\'e Approximants (PA's) of perturbative series become exactly renormalization scale (RS) independent. This symmetry suggest that diagonal PA's are resumming correctly contributions from higher order diagrams that are responsible for the renormalization of the coupling-constant. Non-diagonal PA's are not exactly invariant, but generally reduce the RS dependence as compared to partial-sums. In physical cases, higher-order corrections in the beta function break the symmetry softly, introducing a small scale and scheme dependence. We also compare the Pad\'e resummation with the BLM method. We find that in the large-N_f limit using the BLM scale is identical to resumming the series by a x[0/n]x[0/n] non-diagonal PA.Comment: 25 pages, LateX. Replaced so that the figures would fit into the page siz

    Hegemony through responsibilisation : getting working-class students into higher education in the United Kingdom

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    This article examines the role of the New Labour governments’ agenda for widening participation in higher education as a form of responsibilising discourse of working-class young people. Under the New Labour administrations of 1997—2010, a concerted attempt was made to attract working-class students into higher education through promotional initiatives such as the Aimhigher programme. Drawing from Raymond Williams’ discussion of hegemony and also from Nikolas Rose’s concept of the ‘enterprising self’, this article examines three explanatory/promotional documents from the Aimhigher programme aimed at working-class young people and their parents. The documents are analysed as materialisations of a powerfully hegemonic discourse of ‘responsibilisation’ towards participation in higher education. The article concludes with a discussion of the ways in which the widening access agenda has shifted since the coalition government came to power in 2010

    Production Processes as a Tool to Study Parameterizations of Quark Confinement

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    We introduce diquarks as separable correlations in the two-quark Green's function to facilitate the description of baryons as relativistic three-quark bound states. These states then emerge as solutions of Bethe-Salpeter equations for quarks and diquarks that interact via quark exchange. When solving these equations we consider various dressing functions for the free quark and diquark propagators that prohibit the existence of corresponding asymptotic states and thus effectively parameterize confinement. We study the implications of qualitatively different dressing functions on the model predictions for the masses of the octet baryons as well as the electromagnetic and strong form factors of the nucleon. For different dressing functions we in particular compare the predictions for kaon photoproduction, γp→KΛ\gamma p\to K\Lambda, and associated strangeness production, pp→pKΛpp\to pK\Lambda with experimental data. This leads to conclusions on the permissibility of different dressing functions.Comment: 43 pages, Latex, 28 eps files included via epsfig; version to be published in Physical Review

    Do residents’ perceptions of being well-placed and objective presence of local amenities match? A case study in West Central Scotland, UK

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    Background:&lt;p&gt;&lt;/p&gt; Recently there has been growing interest in how neighbourhood features, such as the provision of local facilities and amenities, influence residents’ health and well-being. Prior research has measured amenity provision through subjective measures (surveying residents’ perceptions) or objective (GIS mapping of distance) methods. The latter may provide a more accurate measure of physical access, but residents may not use local amenities if they do not perceive them as ‘local’. We believe both subjective and objective measures should be explored, and use West Central Scotland data to investigate correspondence between residents’ subjective assessments of how well-placed they are for everyday amenities (food stores, primary and secondary schools, libraries, pharmacies, public recreation), and objective GIS-modelled measures, and examine correspondence by various sub-groups.&lt;p&gt;&lt;/p&gt; Methods:&lt;p&gt;&lt;/p&gt; ArcMap was used to map the postal locations of ‘Transport, Health and Well-being 2010 Study’ respondents (n = 1760), and the six amenities, and the presence/absence of each of them within various straight-line and network buffers around respondents’ homes was recorded. SPSS was used to investigate whether objective presence of an amenity within a specified buffer was perceived by a respondent as being well-placed for that amenity. Kappa statistics were used to test agreement between measures for all respondents, and by sex, age, social class, area deprivation, car ownership, dog ownership, walking in the local area, and years lived in current home.&lt;p&gt;&lt;/p&gt; Results:&lt;p&gt;&lt;/p&gt; In general, there was poor agreement (Kappa &lt;0.20) between perceptions of being well-placed for each facility and objective presence, within 800 m and 1000 m straight-line and network buffers, with the exception of pharmacies (at 1000 m straight-line) (Kappa: 0.21). Results varied between respondent sub-groups, with some showing better agreement than others. Amongst sub-groups, at 800 m straight-line buffers, the highest correspondence between subjective and objective measures was for pharmacies and primary schools, and at 1000 m, for pharmacies, primary schools and libraries. For road network buffers under 1000 m, agreement was generally poor.&lt;p&gt;&lt;/p&gt; Conclusion:&lt;p&gt;&lt;/p&gt; Respondents did not necessarily regard themselves as well-placed for specific amenities when these amenities were present within specified boundaries around their homes, with some exceptions; the picture is not clear-cut with varying findings between different amenities, buffers, and sub-groups

    Serotonin tranporter methylation and response to cognitive behaviour therapy in children with anxiety disorders

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    Anxiety disorders that are the most commonly occurring psychiatric disorders in childhood, are associated with a range of social and educational impairments and often continue into adulthood. Cognitive behaviour therapy (CBT) is an effective treatment option for the majority of cases, although up to 35-45% of children do not achieve remission. Recent research suggests that some genetic variants may be associated with a more beneficial response to psychological therapy. Epigenetic mechanisms such as DNA methylation work at the interface between genetic and environmental influences. Furthermore, epigenetic alterations at the serotonin transporter (SERT) promoter region have been associated with environmental influences such as stressful life experiences. In this study, we measured DNA methylation upstream of SERT in 116 children with an anxiety disorder, before and after receiving CBT. Change during treatment in percentage DNA methylation was significantly different in treatment responders vs nonresponders. This effect was driven by one CpG site in particular, at which responders increased in methylation, whereas nonresponders showed a decrease in DNA methylation. This is the first study to demonstrate differences in SERT methylation change in association with response to a purely psychological therapy. These findings confirm that biological changes occur alongside changes in symptomatology following a psychological therapy such as CBT
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